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Developmental Cell @Dev_Cell

We love (and publish) cell biology, development, and everything in between. Tweets by Dev Cell scientific editors bit.ly/19EEUcT

Joined December 2013
  • Tweets 2,650
  • Following 81
  • Followers 40,518
199 Photos and videos
Online now: Molecular cues from distinct neuron classes drive differential myelination in the neocortex dlvr.it/TSrHcT

Molecular cues from distinct neuron classes drive differential myelination in the neocortex

Domínguez-Iturza et al. characterize oligodendrocyte lineage diversity across cortical layers and developmental stages using single-cell RNA sequencing and generate a molecular interactome to uncover...

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Online now: Ionic regulation of cancer cell stiffness and metastatic colonization via the MRTFA-KCNMB1 axis dlvr.it/TSr72L

Ionic regulation of cancer cell stiffness and metastatic colonization via the MRTFA-KCNMB1 axis

Gajda et al. reveal a mechanism of potassium-ion-channel-dependent physical stiffening of cancer cells. Genetically or pharmacologically activating BK channels stiffens cancer cells and thereby...

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Online now: An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA dlvr.it/TSmwP6

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(Developmental Cell 31, 722–733; December 22, 2014)

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Online now: An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies of peritoneal carcinomatosis dlvr.it/TSkPrj

An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies...

Mahmoud et al. establish a stable organoid biobank from primary appendiceal cancer and paired peritoneal metastases. They reveal that metastases are dedifferentiated and resistant to standard...

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Online now: Spatiotemporal mapping of the contractile and adhesive forces sculpting early C. elegans embryos dlvr.it/TSfcTt

Spatiotemporal mapping of the contractile and adhesive forces sculpting early C. elegans embryos

How cell mechanics, intercellular interactions, and geometrical constraints dynamically interplay to control cell arrangements within embryos is poorly understood. Here, Yamamoto et al. provide...

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Online now: Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation dlvr.it/TSchmq
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Online now: Adhesion-controlled mechanics of the glial niche regulate neural stem cell proliferative potential dlvr.it/TSblLG

Adhesion-controlled mechanics of the glial niche regulate neural stem cell proliferative potential

Segú Cristina et al. move beyond epithelial and matrix-centric mechanotransduction models, demonstrating reciprocal mechanical regulation between distinct cell types and uncovering an original...

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Online now: A machine learning-based megakaryocyte identification system uncovers resident organs, markers, and functional diversity dlvr.it/TSTlSb

A machine learning-based megakaryocyte identification system uncovers resident organs, markers, and...

Xia et al. integrate cross-organ and single-cell datasets to define megakaryocyte (MK) diversity, identify additional markers, and develop a machine learning-based identification system, MKIDS, to...

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Online now: Tumor-intrinsic FDFT1 determines coordinated macrophage anti-tumor immunity dlvr.it/TSHVpl
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Online now: The circadian gene Dec2 promotes pancreatic cancer progression and dormancy through immune evasion dlvr.it/TSGXXW

The circadian gene Dec2 promotes pancreatic cancer progression and dormancy through immune evasion

Wang and Harris et al. identified that the circadian rhythm gene Dec2 is critical for pancreatic cancer cells to escape the immune system through the downregulation of MHC-I antigen presentation and...

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Online now: A skeletal muscle atlas shows neuromuscular junction adaptations to growth and atrophy dlvr.it/TS8Scb

A skeletal muscle atlas shows neuromuscular junction adaptations to growth and atrophy

Campanario et al. present a multimodal, spatially resolved transcriptomic atlas of skeletal muscle responding to neural and mechanical cues during atrophy or hypertrophy. Loss of neural input drives...

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Online now: AMBRA1 enhances Sonic Hedgehog signaling during cerebellar development and in medulloblastoma dlvr.it/TS1HQb

AMBRA1 enhances Sonic Hedgehog signaling during cerebellar development and in medulloblastoma

Basili et al. discovered AMBRA1 as a pro-tumorigenic factor that drives medulloblastoma of the Sonic Hedgehog subtype (MBSHH). AMBRA1 protein abundance is regulated by REN and associated with poor...

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Online now: Host-transposon mutualism supports regeneration in planarians dlvr.it/TRn4M8

Host-transposon mutualism supports regeneration in planarians

Lee et al. find that the planarian transposon Burro1 bolsters stem cell resilience by producing a functional host-derived caspase inhibitor during physiological stress. By suppressing apoptosis,...

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Online now: Unleashing T cell surveillance for the eradication of quiescent persister tumor cells resistant to neoadjuvant chemotherapy dlvr.it/TRjjNZ
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Online now: Hematopoietic stem cells activate a latent differentiation pathway to facilitate recovery after 5-fluorouracil-induced myeloablation dlvr.it/TRgLrb

Hematopoietic stem cells activate a latent differentiation pathway to facilitate recovery after...

(Developmental Cell 61, 1044–1060.e7; May 13, 2026)

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Online now: When stress signals to skin: Sympathetic nerves tune immune surveillance dlvr.it/TRfrf2
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Online now: Reconstructing human corticogenesis: Insights from cerebral organoids into neurodevelopment and disease modeling dlvr.it/TRfhNY

Reconstructing human corticogenesis: Insights from cerebral organoids into neurodevelopment and...

In this review, Tenreiro and Muotri outline the key features of human corticogenesis, examine how cerebral organoids recapitulate these processes in vitro, and evaluate their potential to advance our...

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Online now: Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states dlvr.it/TRfVby

Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate...

Torborg et al. reveal that pancreatic cancer exhibits organized cell-state patterns resembling healthy tissue architecture. WNT-secreting cancer cells form a niche supporting WNT-responding cells,...

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Online now: Multi-omic analyses reveal a differential contribution of chromatin-associated PP1 holoenzymes to mitotic exit and G1 re-establishment dlvr.it/TRXsQd

Multi-omic analyses reveal a differential contribution of chromatin-associated PP1 holoenzymes to...

Stamatiou et al. combine rapid auxin-mediated degradation with multi-omics to dissect the chromatin-associated PP1 holoenzymes Repo-Man, Ki-67, and PNUTS during mitotic exit. The study uncovers...

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Online now: Temporal molecular program of human hematopoietic stem and progenitor cells after birth dlvr.it/TRX7Xw

Temporal molecular program of human hematopoietic stem and progenitor cells after birth

(Developmental Cell 57, 2745–2760.e1–e6; December 19, 2022)

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