For decades, medicine treated irritable bowel syndrome as a stress disease. Mark Pimentel, MD, a gastroenterologist, says about 60 percent of it is something else entirely.
It's small intestinal bacterial overgrowth, or SIBO. The wrong bacteria colonize the small intestine, which is normally relatively clean, and start fermenting your food up to 63 times faster than normal. That is why the classic tell is bloating ten minutes after a meal.
The part most people have never heard: it often starts with food poisoning. Campylobacter, the most common cause of food poisoning in the US, triggers lasting IBS in roughly one in five people who get it. The infection leaves the body producing antibodies against the nerves of its own gut, which slows everything down and lets the bacteria move in.
For years the standard response was to treat the symptoms. A laxative for constipation. An antidiarrheal for diarrhea. Pimentel's argument is that this is backwards.
He describes patients who arrive having had three normal colonoscopies and still no answer, sent for one more test and then another, because the reflex is to keep ruling things out rather than confirm a positive diagnosis. Meanwhile the simplest tell goes unexamined: bloating ten minutes after a meal, the thing many people stopped mentioning years ago because they were told it was anxiety.
There is a breath test that can identify the overgrowth, now even at home, and a non-absorbed antibiotic, rifaximin, that clears it in a two-week course. A patient who responds and feels normal often does not need another colonoscopy, another celiac panel, another year of guessing.
His line is the one worth saving: we shouldn't be treating symptoms in IBS, we should be treating the cause. And he thinks the field is finally getting there, with new diagnostics and treatments in the pipeline that may eventually stop the condition at its source.
Listen to the full conversation on The Podcast by KevinMD. Link in the replies.
If you have IBS, has anyone ever tested you for SIBO, or was it only ever explained as stress?
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