I am sending an open letter to Thermo Fisher. Their response to my response to their manipulated western blot is bullying and petty. Yes, this western blot really is manipulated, it is unfair on me to say otherwise. I don't make those accusations lightly. #ThermoFishy

May was a huge month in AI × biology. Here's a recap of the biggest stories. 🧵 (1/6)

Our large scale foundation model already outperforms highly tuned smaller models, which bodes well for our ability to fundamentally compress the timeline from discovery to clinical application. This is the just the beginning. Leveraging foundation models has the potential to unlock the next generation of precision medicine - improving clinical decisions, optimizing trial design and allowing us to bring novel therapeutics to patients faster.

A reminder that impactful #genomics doesn't always require expensive infrastructure. For this new preprint by @DavidHamelin7 et al, we developed a long-read HLA profiling workflow costing ~US$20 (~A$30) per sample using an @Opentrons OT-2 robot, enabling high-resolution profiling across 500 participants. The science: Using AI to understand how HLA diversity influences susceptibility to immune escape. The bigger picture: personalised MHC modelling is becoming a key foundation for next-generation immunotherapies and #PrecisionMedicine biorxiv.org/content/10.64898…

I seem to be on a genomics world tour: Shenzhen ✈️ London 🚆Belgium ✈️ Montréal ✈️ Vancouver ✈️ Sydney. Across @TheBgiGroup, London Calling @nanopore, @Eurogentec, @RNASociety and soon UBC, one theme keeps coming up: precision medicine is increasingly becoming an organising principle for industry and large-scale genomics infrastructure, while academia often still treats it as a downstream application. I’ll unpack this over a few field notes on scale, AI, nanopore sequencing, manufacturing, RNA biology and translation. Also, unexpectedly, Rosie the dog has somehow become part of the conversation at nearly every stop.

At least 3 different presentations using adaptive @nanopore sequencing for multiomic classification of hematological malignancies @NanoporeConf I think it might be a good solution for cancer diagnostics 😁

Also demonstrates that technology can be used to identify post-translational modifications (phosphorylation) 😎