@martinperaJAX profile picture
Martin Pera @martinperaJAX

Professor @jacksonlab, stem cell biologist

Joined July 2019
  • Tweets 3,138
  • Following 1,998
  • Followers 2,538
9 Photos and videos
Isolation of postnatal human neural stem cells biorxiv.org/content/10.64898…

Isolation of postnatal human neural stem cells

While it was once thought that neurogenesis is complete by birth, it is now apparent that the human brain continues to generate new neurons postnatally, at least into childhood. While much attention...

biorxiv.org
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Two distinct causes contribute to the low efficiency of human pre-impl... sciencedirect.com/science/ar…
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p53 safeguards chemical reprogramming of human somatic cells toward pluripotency: Cell cell.com/cell/fulltext/S0092…

p53 safeguards chemical reprogramming of human somatic cells toward pluripotency

In contrast to its barrier role in transcription factor-driven reprogramming, p53 is indispensable for efficient chemical reprogramming, where p53-competent cells preserve their genomic integrity to...

cell.com
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Continuous modeling of primate embryogenesis from totipotency to early... sciencedirect.com/science/ar…
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Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases biorxiv.org/content/10.1101/…

Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases

Embryogenesis is commonly viewed through a tree model of cell differentiation, which fails to capture the spatiotemporal modulation of cell multipotency underlying morphogenesis. In this study we...

biorxiv.org
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Minimal essential requirements for neural tube self-organisation biorxiv.org/content/10.64898…

Minimal essential requirements for neural tube self-organisation

The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from...

biorxiv.org
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Lineage-selective suicide gene system enables post-engraftment editing of cell therapy composition biorxiv.org/content/10.64898…

Lineage-selective suicide gene system enables post-engraftment editing of cell therapy composition

Human pluripotent stem cell (hPSC)-derived therapies are advancing rapidly toward clinical application, yet heterogeneity of transplanted cell populations remains a major barrier to safety, predict...

biorxiv.org
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Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency: Cell Reports cell.com/cell-reports/fullte…

Poising and connectivity of emergent human developmental enhancers in the transition from naive to...

Nocente et al. show that emergent developmental enhancers in human pluripotent stem cells become poised early in the naive-to-primed transition, while their contacts show diverse temporal dynamics....

cell.com
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Architectural fragility of gene regulatory networks underlies hematopoietic stem cell aging biorxiv.org/content/10.64898…

Architectural fragility of gene regulatory networks underlies hematopoietic stem cell aging

Hematopoietic stem and progenitor cell (HSPC) aging contributes to immune dysfunction and age-associated disease, but its regulatory mechanisms remain unclear. Here, we present the largest single-c...

biorxiv.org
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Splicing of ultraconserved poison exons controls mitotic fidelity and stem cell viability biorxiv.org/content/10.64898…
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Turocy, J., Jerabek, S., Hur, W. et al. Asymmetric attrition and secondary chromosome destabilization after double-strand breaks in human embryonic development. Nat Commun (2026). doi.org/10.1038/s41467-026-7…

Asymmetric attrition and secondary chromosome destabilization after double-strand breaks in human...

Nature Communications - Here the authors use induced DNA double strand breaks to investigate mechanisms leading to genome instability in human embryos. They find that acentric chromosome fragments...

nature.com
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Efficient base editing and development in human embryos without chromosomal alterations biorxiv.org/content/10.64898…

Efficient base editing and development in human embryos without chromosomal alterations

Cas9-based tools enable the introduction of genetic lesions to investigate DNA repair outcomes and edit the genome at disease-relevant loci. DNA double-strand breaks (DSBs) induced by CRISPR/Cas9...

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Thousandfold Expansion Microscopy biorxiv.org/content/10.64898…
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Martin Pera retweeted
Qi Zhou 周琦@zhouqi1982
May 28
nature.com/articles/s41467-0…； academic.oup.com/mbe/article… Do different digits of our hand or foot have a molecular identity and if so, what are their homologies across tetrapods? We published two new works on @NatureComms @MolBioEvol to address the questions.
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Frenster, J.D., Babin, S., Casani-Galdon, P. et al. Mosaic gastruloids reveal a temporal restriction for developmental cell competition. Nat Cell Biol 28, 875–889 (2026). doi.org/10.1038/s41556-026-0…

Mosaic gastruloids reveal a temporal restriction for developmental cell competition

Nature Cell Biology - Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation...

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Pan, J., Li, Y., Lin, Z. et al. Spatiotemporal transcriptome atlas of human embryos after gastrulation. Nature (2026). doi.org/10.1038/s41586-026-1…

Spatiotemporal transcriptome atlas of human embryos after gastrulation

Nature - A spatiotemporal transcriptome atlas of whole-human embryos after gastrulation and previously transcriptionally undescribed stages of human development are reported.

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Chromatin priming by transcription factor ELF3 confers transcriptional competence for amniotic differentiation on primed human embryonic stem cells biorxiv.org/content/10.1101/…
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Genetics of growth rate in induced pluripotent stem cells: Stem Cell Reports cell.com/stem-cell-reports/f…

Genetics of growth rate in induced pluripotent stem cells

Using time-lapse imaging across 602 donors, Lee et al. reveal that iPSC proliferation is shaped by a layered genetic architecture, combining rare large-effect variants with a highly polygenic...

cell.com
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An endodermal subpopulation generates neural and mesodermal fates in the posterior chick embryo biorxiv.org/content/10.64898…
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Martin Pera retweeted
Jennifer Trowbridge@TrowbridgeLab
May 21
Thrilled to share that our Stem Cells & Developmental Biology program at JAX is officially launched. 40 PIs. 60 trainees. >$160M in active NIH funding. Fundamental discovery and translational platforms — in the same world. 🔬 go.jax.org/stem-cell-researc… #JAXresearch #JAXstemcellsdev

Stem Cells & Developmental Biology

By studying how cells are born, integrate, and regenerate, JAX researchers are uncovering the foundations of human health.

jax.org
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