When I was just starting out in venture, a very experienced VC gave me the this advice:
"Our best investments are the ones that don't squarely fit our model. They're too high priced, or low ownership, or off thesis, or maybe the founder doesn't reference well. The fact that we were willing to break our rules to invest was a signal that it was a special company. We put rules in place not to follow them, but to know when something is an extreme outlier"
I think about that all the time.