RAPM is your authoritative medical source for regional anesthesia and pain knowledge – from pediatric to geriatric. The official journal of ASRA. @ASRA_society
🧠 Can psychological factors predict success after SCS?
🔍 Key Findings:
• Higher depressive burden appears to influence early pain-response dynamics at 6 months.
• Certain traits are associated with long-term pain improvement at 12 months.
🔗 doi.org/10.1136/rapm-2025-10…#RAPM
🦠💡 This new study published in RAPM explores whether individuals with nociceptive low back pain, neuropathic low back pain, and pain-free controls have distinct gut microbial signatures.
🔗 READ HERE -> doi.org/10.1136/rapm-2026-10…#RAPM#PainMedicine#ChronicPain
🎖️The first military-specific guidelines for neuromodulation have arrived!
🔑 Highlights include command involvement, opioid tapering before trials, occupational requirements, limited-duty periods after procedures, and functional testing.
🔗 doi.org/10.1136/rapm-2026-10…#RAPM
🩻 Looking Beyond Pain Scores
📚 Pilot RCT comparing ESP catheter, intravenous lidocaine infusion, and multimodal analgesia for rib fractures:
✔ Similar pain scores
✔ Similar opioid use
✔ Less delirium with ESP
🔗 doi.org/10.1136/rapm-2026-10…#RegionalAnesthesia#ESPBlock#RAPM
🚨GLP-1s Show Promise in Knee OA
💡A large cohort study of patients with knee OA found that GLP-1 use was associated with decreased progression to TKA. Benefits were greatest with longer treatment duration and newer agents.
📖 doi.org/10.1136/rapm-2026-10…#RAPM#GLP1#PainMedicine
🧠 Can spinal cord stimulation reduce opioid use?
🔎 This meta-analysis of 43 studies found:
↓ 32% opioid consumption
↓ 18 MME/day at 12 months
↓ 53% odds of continued opioid use after SCS implantation
🔗 doi.org/10.1136/rapm-2026-10…@Ryan_S_DSouzaMD#Neuromodulation#RAPM
🚨 Subperception DRG stimulation vs sham stimulation in established responders
An RCT found subperception DRG stimulation reduced pain vs sham in established responders, with no serious device-related adverse events.
LINK -> doi.org/10.1136/rapm-2026-10…#RAPM#DRG#PainMedicine
📊 Can early pain predict recovery after knee replacement?
In a study of 17,200 patients, two trajectories emerged: low vs high pain.
High pain was linked to more opioid use and consultations.
⚠️ Pain in the first 12–24 hours predicted later outcomes.
🔗doi.org/10.1136/rapm-2026-10…
⚡️From electrical dose to neural dose: redefining SCS
In rat pain models:
• Only suprathreshold spinal cord stimulation worked
• 1.2–1.3×evoked compound action potential threshold gave the best analgesia
• Higher doses added no benefit
🔗 doi.org/10.1136/rapm-2026-10…#RAPM
💉 New approach for axillary nerve block?
📊 Results
• 100% nerve identification
• Staining of anterior & posterior branches in all specimens
• Mean target 0.96 cm from branch bifurcation
May offer a simpler alternative to posterior ANB.
🔗 doi.org/10.1136/rapm-2025-10…#RAPM
Facial pain—especially trigeminal neuralgia—is often misdiagnosed.
An ASRA RAPM paper debunks common myths: MRI isn’t routine, and neurovascular compression ≠ diagnosis.
Bottom line: facial pain is a clinical diagnosis—don’t let imaging lead the way
🔗 doi.org/10.1136/rapm-2025-10…
💡 Plain vs hyperbaric bupivacaine for spinal TKA—does it matter?
A recent RCT says no: both had the same ~33% MAP drop, similar nadir BP, and no difference in vasopressors or side effects
Bottom line: baricity didn’t change early hemodynamics
🔗 doi.org/10.1136/rapm-2025-10…#RAPM
🫀 Regional anesthesia in pediatric cardiac surgery—does it help?
👶 RAPM meta-analysis (31 RCTs) shows ↓ opioids, faster extubation, and shorter ICU stay. But evidence is low quality with high variability.
🔗 doi.org/10.1136/rapm-2025-10…#RAPM#PediatricPain#RegionalAnesthesia
🔍 PENG block for hip arthroscopy—game changer or not?
📚 A RAPM RCT shows ↓ PACU opioids & shorter stays, but no benefit in 24h opioids, pain, or recovery.
💡 Takeaway: modest early gains, no overall impact. Not ready for routine use.
🔗 doi.org/10.1136/rapm-2026-10…#RAPM
🎙️ New RAPM Focus Podcast 50!
💊 Brian Sites, MD, Eric Schwenk, MD, and Kishor Gandhi, MD, discuss the pros and cons of perioperative gabapentinoids and why a nuanced, patient-specific approach matters.
🔗 rapmfocusbmj.podbean.com/e/e…#RAPM#Anesthesiology#PainMedicine