UniProt is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation.
Joined June 2011
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AI-generated protein annotations are expanding in UniProtKB. The new ProtNLM2 pilot dataset from @GoogleDeepMind covers 26K entries, predicting protein name, function, localization, keywords, and GO terms, supported by evidence-based corroboration. uniprot.org/help/ProtNLM
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Our new data release (2026_02) has just gone live and in this release headline we introduce the osmosensor TMEM63B that triggers our sense of thirst.
Read our release header for the full story: uniprot.org/release-notes/20…
See TMEM63B entries in UniProtKB: uniprot.org/uniprotkb/?query…
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We’re recruiting!
Come and join us as our UniProt Protein Function Development Team Leader, based at @emblebi in Cambridge, UK.
Apply here: embl.wd103.myworkdayjobs.com…
Applications close on 15th July 2026.
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UniProt release 2026_02 is now live!
This new UniProt data release completes the reorganization of the protein space within UniProt, and includes updates to all four resources
Read the full release notes: uniprot.org/release-notes/20…
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UniProt Webinar reminder – Join us to learn about the proteomes resource.
Proteomes in UniProt – explore and analyse the proteome resource.
15.00 (BST) Thursday 18th June.
Registration is free but essential: ebi.ac.uk/training/events/pr…
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New Protein Spotlight blog post
In this article we explore how the serotonin receptor HTR2A responds to psilocybin, a hallucinogen produced by “magic mushrooms”.
Read the blog here: proteinspotlight.org/back_is…
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Big changes to UniProt proteomes are coming in our next release.
See our blog post: insideuniprot.blogspot.com/2…
For details of our new reference selection workflow: biorxiv.org/content/10.64898…
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New UniProt Webinar – Join us to learn about the proteomes resource.
Proteomes in UniProt – explore and analyse the proteome resource.
15.00 (BST) Thursday 18th June.
Registration is free but essential: ebi.ac.uk/training/events/pr…
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A new report on EMBL-EBI resources by Frontier Economics shows how tools like UniProt save time, boost productivity and support interdisciplinary collaboration.
Read the report highlights: ebi.ac.uk/about/our-impact/2…
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Big update for SIFTS, our long-standing collaboration with @PDBeurope!
PDBe-SIFTS is now fully open-source, featuring improvements in speed and performance, and expanded compatibility for custom protein sequences and structures.
Visit PDBe-SIFTS Github: github.com/PDBeurope/SIFTS
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PDBe-SIFTS is now open source 🎉
Developed in collaboration with @PDBeurope and @uniprot , it enables fast, accurate residue-level mapping between protein sequences and structures, achieving >93% agreement with curated mappings.
Get started: github.com/PDBeurope/SIFTS
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New Homologs section
Contains Orthologs and Paralogs from the Alliance of Genome resources and cross references to multiple phylogenomic database and organism-specific databases.
See new Homologs section in APP (P05067) - uniprot.org/uniprotkb/P05067…
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UniProt Webinar Reminder – Join us to find out what’s new on the UniProt website.
What’s new on the UniProt website: features and improvements for 2026
15.00 (BST) Thursday 14th May.
Registration is free but essential: ebi.ac.uk/training/events/wh…
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UniProt helps shed light on the dark proteome
The TransCODE Consortium has uncovered 1,700 new proteins that could be linked to human health. This work also reveals new protein-coding genes that are now available in UniProt.
Read the paper in Nature: nature.com/articles/s41586-0…
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New UniProt Webinar – Join us to find out what’s new on the UniProt website.
What’s new on the UniProt website: features and improvements for 2026
15.00 (BST) Thursday 14th May.
Registration is free but essential: ebi.ac.uk/training/events/wh…
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UniProt is attending HUPO-PSI
Emily is a senior curator and project liaison who drives the integration of proteomics data into UniProt resources and facilitates the presentation and documentation of biological data on the UniProt website
Emily will attend the MS and MOD sessions
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New Protein Spotlight blog post
In this article we highlight how the enzyme TGDS supports UXS1 in building the extracellular matrix.
Read the blog here: proteinspotlight.org/back_is…
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UniProt Webinar Reminder – Join us to learn about enzymes in UniProt.
Accessing enzyme characterisation and functional annotation in UniProt.
14.00 (BST) Thursday 7th May.
Registration is free but essential: ebi.ac.uk/training/events/ac…
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UniProt is attending @Biocuration2026 in Cape Town, South Africa
Stephanie Lo leads the UniProt EMBL-EBI expert curation team and has a special interest in how AI methodologies can lend a helping hand in curation of biological data.
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