Q4: #ESHREjc Until prospective data arrive, what’s a proportionate counseling message for TTC/IVF patients needing analgesia, what alternatives, what timing advice, and how to avoid over-restriction that drives unsafe NSAID substitution? @ESHRE
This edition’s paper is “Paracetamol (N-acetyl-para-aminophenol) disrupts early embryogenesis by cell cycle inhibition” published in our science journal Human Reproduction 👩🎓
🔗doi.org/10.1093/humrep/deaf1…#ESHREjc
Q4: #ESHREjc Until prospective data arrive, what’s a proportionate counseling message for TTC/IVF patients needing analgesia, what alternatives, what timing advice, and how to avoid over-restriction that drives unsafe NSAID substitution? @ESHRE
🚨Q1 #ESHREjc The study finds that APAP delays cleavage-stage divisions, while blastocysts keep total cells but show reduced ICM and DNA synthesis. What do these stage-specific vulnerabilities imply for implantation and embryo competence?
@ESHRE
1/ This #ESHREjc we are discussing how a common analgesic Acetaminophen (APAP) may interfere with pre-implantation embryo development.
Study in focus: doi.org/10.1093/humrep/deaf1…
A tweetorial to get you up and ready for tomorrow.
#ESHREjc@ESHRE
🚨 Could a common painkiller disrupt the earliest stages of human embryo development?
Join us for the next #ESHREjc
🗓️ 28–29 November
⏰ 17:00 CET start
📍 on @ESHRE
🔗 doi.org/10.1093/humrep/deaf1…
🌟 @juliauraji, Thanos Papathanasiou & David Kristensen
Q3: What are the main diagnostic pitfalls in adenomyosis? How do clinical outcomes differ in subtypes of adenomyosis? Should we define specific criteria to identify those women at higher risk? #ESHREjc@CatenaUrsula@AlexQuaas
Q4: Moving into the “ideal” setting of IVF.
✨LBR after multiple ET reach 60–70% in women <35 years….
🔎to what extent can the remaining failure be explained by uterine factors? could this account for the entire 30–40%? Or are we missing something else? #ESHREjc
🚨Q2:
Prevalence of uterine anomalies (e.g. septate uterus) shifts a lot by criteria (ESHRE/ESGE vs ASRM vs CUME).
👉🏼How does this shape practice over/under-diagnosis, over/under-treatment and interpretation of treatment outcomes?
#ESHREJC
Q1: To demonstrate a causal role of the uterine factor on RPL, a control group of 👭is needed with
-previous fertility
-no previous abortions
-with a 3D transv US
Is this a feasible endevour? Can causality be inferred even if diagnostic guidelines are heterogeneous? #ESHREjc
Adenomyosis is a “shades of gray” rather than “black and white” condition so it is challenging to establish association vs causation and clinical relevance.
Should we define high-risk criteria?
Yes — combining:
Quantitative JZ metrics.
Number of MUSA features (≥2 direct signs).
Clinical phenotype (primary RPL, multiple losses).
This could identify women most likely to benefit from early interventions or closer monitoring.
Q4: Moving into the “ideal” setting of IVF.
✨LBR after multiple ET reach 60–70% in women <35 years….
🔎to what extent can the remaining failure be explained by uterine factors? could this account for the entire 30–40%? Or are we missing something else? #ESHREjc
Q3: What are the main diagnostic pitfalls in adenomyosis? How do clinical outcomes differ in subtypes of adenomyosis? Should we define specific criteria to identify those women at higher risk? #ESHREjc@CatenaUrsula@AlexQuaas
🚨Q2:
Prevalence of uterine anomalies (e.g. septate uterus) shifts a lot by criteria (ESHRE/ESGE vs ASRM vs CUME).
👉🏼How does this shape practice over/under-diagnosis, over/under-treatment and interpretation of treatment outcomes?
#ESHREJC
This edition’s paper is “The importance of the ‘uterine factor’ in recurrent pregnancy loss: a retrospective cohort study on women screened through 3D transvaginal ultrasound” published in our science journal Human Reproduction 👩🎓
🔗 doi.org/10.1093/humrep/deae1…#ESHREjc
Interesting point 👀.
A control group with prior fertility, no miscarriages, and 3D US would be valuable to test the uterine factor’s causal role in RPL.
👉 The challenge is recruitment, plus heterogeneous diagnostic guidelines make causal inference tricky.
#ESHREJc
Q1: To demonstrate a causal role of the uterine factor on RPL, a control group of 👭is needed with
-previous fertility
-no previous abortions
-with a 3D transv US
Is this a feasible endevour? Can causality be inferred even if diagnostic guidelines are heterogeneous? #ESHREjc