Brett, please talk about the Biogenesis and Morphogenesis problems in Biology. In what ways have they been solved & in what ways do they remain open questions? How does the work of e.g Stuart Kauffman & e.g. Frances Arnold fit into these topics?

Lebron's manager and wife crew loved Biogenesis.

ESPACIO SOLICITADO | BIOGENESIS BAGO🐃 ¡El antiparasitario que tu hato merece, de la marca que confías y que entrega lo que promete! Eficaz, confiable y seguro, FORBOX® FT reescribe el modo de combate y tratamiento contra garrapatas, miasis y moscas con un poder residual 32 días.

ESPACIO SOLICITADO | BIOGENESIS BAGO🐃🐂 🐄💪 Fortalezca la salud y productividad de su hato con SUPLENUT®. La suplementación estratégica con Cobre y Zinc ayuda a mejorar la inmunidad, favorecer el desarrollo muscular y acompañar una mejor eficiencia productiva en cada etapa.

HIV Tat Protein Induces the TGF-β Signaling Pathway and Suppresses the CFTR Biogenesis and Activity by microRNA-Regulated Gene-Silencing Mechanism faseb.onlinelibrary.wiley.co…

New paper from the Feradical Lab in @NatureComms! We swapped a single N→S atom at Trp105 in KatG and completely reprogrammed its chemistry — redirecting radical cofactor biogenesis to stereoselective sulfoxidation, captured in a 2.22 Å cryo‑EM structure. doi.org/10.1038/s41467-026-7…

March 26, 2024 SARS-CoV-2 targets ribosomal RNA biogenesis cell.com/cell-reports/fullte…

#OpenAccess #Article 📑Title: [Pd(dach)Cl2] Complex Targets #Proteins Involved in Ribosomal #Biogenesis, and #RNA Splicing in #HeLa Cells Authors: Vanja Ralić et al. 📌 brnw.ch/21x3of9

🌊 AESTHETICS — 48 Benefits 1. Radiant, luminous skin that glows from within 2. Perfect facial symmetry and divine proportions 3. Hair that grows thick, lustrous, and vibrant 4. Eyes that sparkle with inner light and depth 5. Posture of regal grace and effortless elegance 6. Voice that carries natural resonance and magnetism 7. Natural scent that is subtly intoxicating and unique 8. Movement that flows with liquid, artistic grace 9. Presence that commands attention without effort 10. Smile that lights up rooms and heals hearts 11. Skin texture that is soft, firm, and youthful 12. Eyebrows and lashes that frame the eyes perfectly 13. Jawline and facial structure of classical beauty 14. Body proportions that feel harmonious and divine 15. Natural glow that increases with emotional state 16. Teeth that are naturally white and perfectly aligned 17. Nails that grow strong, clear, and beautiful 18. Overall facial harmony that inspires awe 19. Natural charisma that draws people in 20. Aura that feels warm, safe, and magnetic 21. Skin tone that is even, vibrant, and healthy 22. Lips that are naturally full and expressive 23. Neck and shoulders that carry noble bearing 24. Hands that move with artistic sensitivity 25. Overall physical beauty that deepens with age 26. Natural photogenic quality in any lighting 27. Voice timbre that is soothing and powerful 28. Eye contact that feels deeply connecting 29. Natural elegance in movement and stillness 30. Facial expressions that convey depth and warmth 31. Body language that communicates confidence and openness 32. Natural symmetry in all physical features 33. Skin that heals quickly and beautifully 34. Hair color and texture that enhances natural beauty 35. Overall aesthetic that feels timeless and divine 36. Presence that makes others feel more beautiful 37. Natural radiance that increases with joy 38. Facial features that express inner light 39. Body that moves with artistic, flowing grace 40. Natural beauty that requires minimal enhancement 41. Voice that carries emotional depth and resonance 42. Eyes that convey wisdom, warmth, and depth 43. Overall form that feels like living art 44. Natural glow that responds to emotional states 45. Physical presence that inspires and uplifts 46. Beauty that is both striking and deeply comforting 47. Aesthetic that feels uniquely and divinely yours 48. Radiance that continues to deepen throughout life 🌿 HEALTH — 48 Benefits 1. Perfect cellular regeneration and repair 2. Optimal mitochondrial function and energy production 3. Strong, flexible, and resilient immune system 4. Perfect hormone balance and regulation 5. Deep, restorative, and rejuvenating sleep 6. Strong cardiovascular health and circulation 7. Optimal digestive function and gut microbiome 8. Strong, flexible joints and connective tissue 9. Perfect blood sugar regulation and metabolic health 10. Strong, dense, and resilient bones 11. Optimal brain function and neuroplasticity 12. Strong, healthy lungs and respiratory system 13. Perfect liver and kidney function 14. Strong, resilient nervous system 15. Optimal thyroid and endocrine function 16. Strong, healthy reproductive system 17. Perfect pH balance and internal environment 18. Strong, efficient lymphatic system 19. Optimal inflammation response and resolution 20. Strong, resilient telomeres and cellular longevity 21. Perfect hydration and cellular water balance 22. Strong, healthy hair, skin, and nails 23. Optimal detoxification and elimination 24. Strong, resilient stress response system 25. Perfect blood pressure and vascular health 26. Strong, healthy vision and eye function 27. Optimal hearing and auditory processing 28. Strong, resilient immune memory 29. Perfect cellular communication and signaling 30. Strong, healthy gut-brain axis 31. Optimal mitochondrial biogenesis 32. Strong, resilient DNA repair mechanisms

4/6 According to this view, mitochondrial toxicity may contribute to reduced ATP levels, loss of mitochondrial membrane potential, impaired mitochondrial biogenesis and density, activation of permeability transition pathways, apoptosis, and calpain-mediated cell death. /5

Mitochondrial biogenesis gets most of the attention in metabolic health research. More mitochondria means more ATP production capacity. PGC-1α activation, exercise-induced adaptations, NAD precursors—they all increase mitochondrial quantity. But quantity isn't the limiting factor in age-related metabolic decline. Efficiency is. You can have abundant mitochondria that produce ATP poorly. The electron transport chain becomes less coupled with age—meaning more oxygen is consumed to generate the same amount of ATP. This is proton leak: hydrogen ions bypass ATP synthase and cross the inner mitochondrial membrane without driving ATP production. The energy dissipates as heat instead of being captured in high-energy phosphate bonds. Young, healthy mitochondria have tightly regulated proton gradients. The electron transport chain pumps protons across the membrane, creating an electrochemical gradient that drives ATP synthase rotation when protons flow back through. Aged or damaged mitochondria allow protons to leak across the membrane through non-ATP-producing channels. The gradient weakens. ATP synthase spins less efficiently. Energy production drops even when oxygen delivery and substrate availability remain adequate. This explains why metabolic rate can decline even when mitochondrial content stays stable or increases. You're not producing less ATP because you have fewer mitochondria—you're producing less because the mitochondria you have are working inefficiently. Reactive oxygen species accelerate the problem. As electron transport chain efficiency declines, more electrons leak prematurely and reduce oxygen to superoxide instead of water. Superoxide damages mitochondrial membranes and proteins, worsening coupling efficiency in a self-reinforcing cycle. Mitochondrial membrane potential is the functional biomarker. It reflects how well the proton gradient is maintained. When membrane potential drops—even slightly—it signals declining coupling efficiency and increased leak. Cardiolipin is a key structural component of the inner mitochondrial membrane, essential for maintaining electron transport chain complex stability and proton impermeability. It oxidizes with age, particularly in response to reactive oxygen species. When cardiolipin integrity declines, membrane structure destabilizes. Proton leak increases. Electron transport chain complexes lose functional coupling. ATP production becomes less efficient per oxygen molecule consumed. This is why interventions targeting mitochondrial quality—not just quantity—may be more relevant for age-related metabolic decline. Urolithin A enhances mitophagy, clearing dysfunctional mitochondria and allowing healthier ones to persist. NAD precursors support sirtuin activity, which regulates mitochondrial protein acetylation and improves oxidative phosphorylation efficiency. Coenzyme Q10 stabilizes the electron transport chain and reduces electron leak. These interventions don't necessarily increase mitochondrial number. They improve the function of existing mitochondria by reducing oxidative damage, stabilizing membrane integrity, and enhancing coupling efficiency. Exercise does both. Endurance training increases mitochondrial content through PGC-1α signaling. But it also improves mitochondrial efficiency by reducing oxidative stress, enhancing antioxidant defenses, and promoting mitophagy to clear damaged mitochondria. The net result: more mitochondria that work better. But in sedentary aging, mitochondrial content may stay relatively stable while efficiency declines. Adding more mitochondria through biogenesis activators won't fix inefficient ones. And inefficient mitochondria consume oxygen without proportionally increasing ATP output—creating the metabolic profile of declined energy expenditure despite adequate mitochondrial mass. Our latest Research Review examines mitochondrial coupling efficiency, why it declines with age, and which interventions target quality rather than quantity. gethealthspan.com/research/a…

I love Trae. Wanted him for years. But going from Giannis to Trae is a humongous letdown 😭 especially if Giannis ends up in Boston. I deadass would rather try my luck with Embiid and send him to the biogenesis clinic

This was the answer… “Professor Leslie M. Thompson (UC Irvine) has focused her clinical and translational neurology efforts almost exclusively on Huntington’s disease (HD) over the past four years (roughly 2022–2026), with no publicly documented involvement in other neurology clinical programs or trials outside of HD.2731 Her work centers on stem cell-based therapies, mechanistic studies, and repurposed drugs for HD. Key highlights include: •REGEN4HD (NCT07451613): This is the ongoing first-in-human Phase 1b/2a trial of hNSC-01 (human neural stem cells) for HD safety and tolerability. She is the sponsor and lead investigator. The first participant was dosed recently (around mid-2026), supported by substantial CIRM funding (including a ~$12 million award in late 2025, building on prior ~$6 million in 2019 and others). This is her most prominent recent clinical program.02731 •Fenofibrate trial (NCT03515213): She served as Study Director for this Phase 2 study evaluating the safety and efficacy of fenofibrate (an approved lipid-lowering drug) as a potential HD treatment, targeting mitochondrial biogenesis/PGC-1α pathways. It was listed as active/not recruiting in some records from the period.85 Her broader recent activities (preclinical/translational, often feeding into clinical work) include: •Multiple CIRM-funded projects on HD mechanisms, iPSC models, protein interactions, gene therapy collaborations (e.g., with Beverly Davidson on PIAS1/MSH3), and stem cell delivery approaches.2640 •Leadership in HD-focused conferences and consortia (e.g., SC4HD/Stem Cells for HD).99 •Publications and commentary on HD RNA processing, selective neuron vulnerability, and therapeutic targets (e.g., 2025 work quoted in Science).24 No evidence appears of her leading or participating in clinical programs for other neurological conditions (e.g., Parkinson’s, ALS, Alzheimer’s, or stroke) in this timeframe. Her lab has historically explored stem cell models for FGFR3-related cancers alongside HD, but this has not extended to neurology clinical trials.94 This focus aligns with her long-term expertise (over 30 years on HD) and funding from CIRM, HDF, and NIH emphasizing HD regenerative and disease-modifying approaches. Information is based on public sources like ClinicalTrials.gov, CIRM, UCI announcements, and publications up to mid-2026.”

He’s good enough but being linked to Biogenesis disqualifies him imo

According to the current model matter came first. The question is at what point did matter (hydrogen, helium....) become a living cell. That's biogenesis. How did microbes come to exist after matter came into space time? Anyway have a great day dee Jay.

Adaptive Thermal Endothermic Response) Gel. ​PHASE II: THE FOUNDRY-LATTICE INTEGRATION (The A.T.E.R. System) ​Once the base is established, the ships become "Living Exoskeletons." ​Synthetic Biogenesis: The Foundry "brews" the A.T.E.R. gel using Martian regolith precursors (

You've proven biogenesis? Wow you've taken mineral matter and created a living replicating biological cell? When did science do that?

Read the law of biogenesis and you will realize that there is a Creator.