$SKNY LIR Life Sciences Completes Comparative Animal Study Showing Successful Protamine-Enhanced Permeation Transport ... accessnewswire.com/newsroom/…
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Dr. Muhammad Moor retweeted
Jun 16
Why is Protamine Sulfate considered both a drug and an antidote.?
Experience-based question. 📌
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Protamine sulfate is used principally as a drug to reverse the effects of heparin. It is also occasionally used in gene transfer. Protamine (usually the zinc preparation) is added to certain insulins in order to lengthen their effects.)
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Akoh Victor retweeted
Jun 16
Antidote for enoxaparin (Clexane) overdose?
A) Vitamin K
B) Protamine sulfate
C) Naloxone
D) Deferoxamine
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✨ retweeted
Jun 16
Correct Antidote: Protamine sulfate (Option B) for enoxaparin (Clexane) overdose.
Enoxaparin is a low-molecular-weight heparin (LMWH) used as an anticoagulant.
Protamine sulfate partially neutralizes LMWH (more effective against unfractionated heparin).
Other options are incorrect:-
Vitamin K - Warfarin reversal
Naloxone - Opioid reversal
Deferoxamine - Iron chelation
Note: In severe bleeding, supportive care (e.g., blood products) is also needed alongside protamine.
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Protamine sulfate is used to reverse enoxaparin (Clexane), although reversal is less complete than with unfractionated heparin.
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Jun 16
Protamine sulfate is a drug (positively charged protein from fish sperm) that binds and neutralizes heparin, making it the specific antidote for heparin overdose or reversal.
Its main use is as an antidote, but it’s a medication with its own mild anticoagulant effects if given alone.
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Jun 16
Protamine sulfate is a drug when used therapeutically to reverse heparin anticoagulation (e.g., after cardiac surgery).
It’s an antidote when given to treat heparin overdose or bleeding due to excess heparin. Same molecule, different clinical context.
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🐣 retweeted
Jun 16
Correct Answer: B. Protamine sulfate
➜ Enoxaparin (Clexane) is a low molecular weight heparin (LMWH).
➜ The specific antidote is protamine sulfate, which partially reverses its anticoagulant effect.
➜ It works by binding to heparin and neutralizing its activity.
➜ Vitamin K is for warfarin, naloxone for opioids, and deferoxamine for iron toxicity.
Answer: B. Protamine sulfate ✅
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