Big insights from a tiny dataset ⚡️ CryoCloud Map of the Month: SARS-CoV-2 Spike Protein For September, we spotlight a vaccine research use case. In antigen design, cryo-EM is used to confirm that engineered proteins fold into the correct conformation and present key neutralising epitopes – both critical checkpoints before immunogenicity testing in the lab. 🔬 From a small Glacios screening dataset, we obtained a 3.2 Å map of the SARS-CoV-2 spike ectodomain, showing that even small datasets can confirm structural integrity and epitope accessibility, accelerating design decisions in vaccine R&D. 🧠 Processing on CryoCloud: • 233 movies • 3 h 20 min processing • 3.2 Å final map This month’s MOTM shows you don’t always need massive datasets or complex pipelines. With a solid sample, answers can come fast 🚀 Curious what CryoCloud could do with your data? Send us a DM for more info or visit cryocloud.io! #CryoEM #StructuralBiology #VaccineDesign #AntigenDesign #SBDD #MapOfTheMonth #MOTM #CryoCloud

plus bessere FCγ Effektorfunktion. Durch Matrix-M und das Antigendesign auf konservierte Epitope löst Novavax eine breitere Immunantwort aus, JN.1 funktioniert. 4/x