Excited to see this out! We introduce CalTRAP, a calcium-dependent, ribosome-specific biotinylation system built on our Cal-ID proximity labeling tool, and identify a gene-expression program in spontaneously active neurons that differs from the classic IEG response. Check it out:
Neuronal stimulation induces immediate early genes (IEGs) such as Fos. But what about the continuous, spontaneous activity neurons experience most of the time? Does ongoing network activity also shape gene expression? If so, which genes are regulated?
biorxiv.org/content/10.64898…