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トンヌラ @37phoenix

へっぽこ内科医。なんちゃって感染症専門医。論文メモ。

Joined November 2011
  • Tweets 4,563
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  • Followers 2,135
23 Photos and videos
成人の自殺念慮の評価と管理。BMJ. 2026;393:e086834. pubmed.ncbi.nlm.nih.gov/4225…

Clinical updates: Assessment and management of suicidal ideation in adults - PubMed

Clinical updates: Assessment and management of suicidal ideation in adults

pubmed.ncbi.nlm.nih.gov
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米国の黄色ブドウ球菌菌血症においてメチシリン耐性は感性と比較して若年者、低BMI、ivdu、皮膚軟部組織感染、低い重症度と関連していた。MRは死亡率や再入院率、遠隔合併症、心内膜炎とは関連が見られなかった。Ladines-Lim JB. Open Forum Infect Dis. 2026;13: ofag354. academic.oup.com/ofid/articl…

Impact of Methicillin Resistance on Outcomes of Staphylococcus aureus Bacteremia at a U.S. Center,...

In a contemporary academic cohort of adults with Staphylococcus aureus bacteremia, methicillin resistance was associated with distinct epidemiologic charac

academic.oup.com
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病院のシンクはMycobacteerium abscessusの感染源となりえる。JAMA Netw Open. 2026; 9:e2617898. PMID: 42275063. pubmed.ncbi.nlm.nih.gov/4227…

Hospital Environment-Associated Sources of Mycobacterium abscessus Infection in Transplant Recipi...

In this cohort study of patients with MAB, the results implicated tap water in patient care units as the likely source of MAB infections and showed that most strains infecting patients belonged to...

pubmed.ncbi.nlm.nih.gov
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6～12歳の小児に対する0.01％アトロピン点眼は近視の進行を遅らせた。CHAMP-UK試験。BMJ.2026;393:e086698. PMID: 42276557. pubmed.ncbi.nlm.nih.gov/4227…

Low concentration atropine eye drops and progression of myopia in children: multicentre placebo...

ISRCTN registry ISRCTN99883695, ClinicalTrials.gov NCT03690089.

pubmed.ncbi.nlm.nih.gov
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乳房インプラント感染の保存的治療。達成率66.7%. 33%で瘻孔あり、治療失敗と強く関連。黄ブ菌36.8%、表皮ブ菌31.6%。Idoia Bilbao Open Forum Infect Dis. 2026:ofag351. academic.oup.com/ofid/articl…

Conservative Management of Breast Implant–Associated Infections: Identifying Risk Factors for...

AbstractBackground. Breast implant–associated infections remain a challenging complication, with limited high-quality evidence to guide management. Implant

academic.oup.com
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市中肺炎の抗菌薬治療に対するエビデンスと実践のギャップ。コレスポンデンス。Phuong T K Nguyen. Clin Infect Dis. 2026:coag336. PMID; 42208946. pubmed.ncbi.nlm.nih.gov/4220…

Persistent evidence practice gap in antibiotic use for community acquired pneumonia - PubMed

Persistent evidence practice gap in antibiotic use for community acquired pneumonia

pubmed.ncbi.nlm.nih.gov
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高血圧症のreview. In The Clinic. Ann Intern Med. PMID: 42258825. pubmed.ncbi.nlm.nih.gov/4225…

Hypertension - PubMed

Updated U.S. and international hypertension guidelines reflect new studies and analyses that support changes in hypertension management. The 2025 U.S. guideline for prevention, detection, evaluation,...

pubmed.ncbi.nlm.nih.gov
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カルバペネマーゼの世界的な疫学、検出、治療。JAC Antimicob Resist. 2026;8:dlag099. PMID: 42267316. pubmed.ncbi.nlm.nih.gov/4226…

Carbapenemases: epidemiology, detection and management in a changing global landscape - PubMed

Carbapenemase-producing Gram-negative bacteria are a growing threat to last-line beta-lactam (BL) therapy and are now established across Enterobacterales, Pseudomonas aeruginosa and Acinetobacter...

pubmed.ncbi.nlm.nih.gov
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非心臓大手術時におけるトラネキサム酸の投与の病院ポリシーは赤血球輸血の発生率低下と関連した。VTE診断率はプラセボに非劣勢。TRACTION試験。N Engl J Med. PMID: 42267805. pubmed.ncbi.nlm.nih.gov/4226…

Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery - PubMed

Among patients undergoing major noncardiac surgery, a hospital policy of tranexamic acid administration resulted in a lower incidence of red-cell transfusion than placebo administration, and tranex...

pubmed.ncbi.nlm.nih.gov
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皮膚軟部組織感染症に対するセファレキシンやセファドロキシル内服の最適化。Review. Pharmacotherapy. 2026;46:e70179. PMID: 42272168. pubmed.ncbi.nlm.nih.gov/4227…

Getting It Right the Second Time: How Can we Optimize First-Generation Cephalosporin Dosing for...

Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies...

pubmed.ncbi.nlm.nih.gov
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小児、思春期のADHDの治療の進歩。BMJ. 2026;393:e082507. PMID: 42259585. pubmed.ncbi.nlm.nih.gov/4225…

Advances in the management of ADHD in children and adolescents - PubMed

This review synthesizes evidence on managing attention deficit/hyperactivity disorder (ADHD) in children and adolescents, focusing on studies published between 2019 and 2025. Recent research supports...

pubmed.ncbi.nlm.nih.gov
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人工呼吸器管理を受けている重症患者に対してカルボシステインの内服や高張食塩水の吸入はどちらも人工呼吸器の期間を短縮しなかった。カルボシステイン群では上部消化管出血が多く、食塩水吸入では気管支収縮、吸入中の低酸素が多かった。N Engl J Med. PMID: 42267821.pubmed.ncbi.nlm.nih.gov/4226…

Carbocisteine or Hypertonic Saline for Acute Respiratory Failure - PubMed

Among critically ill patients with acute respiratory failure, neither carbocisteine nor HTS significantly reduced the duration of mechanical ventilation, and each was associated with harm. (Funded by...

pubmed.ncbi.nlm.nih.gov
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高齢者の炎症性関節痛の評価。JAMA Intern Med. PMID: 42258207. pubmed.ncbi.nlm.nih.gov/4225…

Evaluating Inflammatory Joint Pain in Older Adults-Practical Diagnostic Clues for Primary Care...

Evaluating Inflammatory Joint Pain in Older Adults-Practical Diagnostic Clues for Primary Care Clinicians

pubmed.ncbi.nlm.nih.gov
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BALANCE試験のサブグループ解析では免疫抑制者でも菌血症に対して7日と14日の治療で90日死亡は変わらず。好中球減少患者の参加はわずか。固形臓器腫瘍75%、白血病・リンパ腫10%、化学療法15%、ステロイド4.7%. Michelle Hamani. Clin Microbiol Infect. PMID: 42264033. pubmed.ncbi.nlm.nih.gov/4226…

Duration of antibiotic therapy for bacteremia in immune compromised hosts-a post hoc subgroup...

This post-hoc analysis of immune compromised subgroup of the BALANCE RCT, suggests that the shorter treatment duration was sufficient for bacteremia in these patients.

pubmed.ncbi.nlm.nih.gov
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hVISAのメタ解析。BMC Infect Dis. PMID: 42251270. pubmed.ncbi.nlm.nih.gov/4225…

The global scope of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA): a meta-a...

hVISA represents a clinically relevant phenotype associated with an increased likelihood of vancomycin treatment failure and a modest elevation in mortality risk. The association with persistent...

pubmed.ncbi.nlm.nih.gov
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妊娠梅毒治療における経口アモキシシリンの薬物動態。Jodie A Dionne. Open Forum Infect Dis. 2026:ofag336. academic.oup.com/ofid/articl…

Pharmacokinetics of Oral Amoxicillin for the Treatment of Syphilis in Pregnancy

Data on amoxicillin concentrations in pregnancy are needed to inform syphilis treatment trials. This pharmacokinetic study suggests that three times daily

academic.oup.com
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ARDSは予防可能な疾患か。Narrative review. Intensive Care Med. PMID: 42257879. pubmed.ncbi.nlm.nih.gov/4225…

Is acute respiratory distress syndrome a preventable disease? - PubMed

Extending prevention beyond iatrogenic causes will require precision approaches: phenotype-targeted pharmacotherapy, individualized mechanical ventilation, and systematic implementation of evidence...

pubmed.ncbi.nlm.nih.gov
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ハンタウイルスについて集中治療医が知っておくべきこと。Intensive Care Med. PMID: 42257876. pubmed.ncbi.nlm.nih.gov/4225…

What intensivist need to know about hantavirus cardiopulmonary syndrome - PubMed

What intensivist need to know about hantavirus cardiopulmonary syndrome

pubmed.ncbi.nlm.nih.gov
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造血幹細胞移植患者の好中球減少期におけるキノロンの予防投薬中止は菌血症の増加と関連していた。薬剤耐性負荷の減少とは関連せず。死亡率は有意な上昇なし。キノロン中止後のGN菌血症はキノロンやカルバ耐性が少なかった。Randi BA. Open Forum Infect Dis. 2026:ofag358. academic.oup.com/ofid/articl…

Effect of quinolone prophylaxis discontinuation during pre-engraftment neutropenia on incidence,...

Our systematic review with meta-analysis suggests that discontinuation of quinolone prophylaxis during pre-engraftment neutropenia reduces bacterial resist

academic.oup.com
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口腔ケアの強化(専任看護師による口腔ケアの提供と製品の提供、患者とスタッフへの教育、監査とフィードバック)は通常ケアと比較して院内肺炎を低下させた(累積HR 0.4)。クラスターRCT. HAPPEN試験。White NM. Lancet Infect Dis. thelancet.com/journals/lanin…

Effectiveness of oral care for the prevention of non-ventilator hospital-acquired pneumonia...

This multicentre randomised controlled trial demonstrates that improving oral care reduces NV-HAP incidence among hospitalised patients, compared with usual care. Our findings provide novel and...

thelancet.com
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