The official journal of @ASTCT.
Joined April 2020
- Tweets 1,307
- Following 60
- Followers 4,285
- Likes 2,511
Photos and videos
This study shows that simultaneous NOD1 and NOD2 deletion in HSPCs significantly increased donor cell reconstitution and long-term chimerism in syngeneic and fully allogeneic recipients while preserving alloresponsiveness and tumor immunosurveillance. astctjournal.org/article/S26…
1
1
418
This review paper provides an updated overview of the current strategies and recommendations for fertility preservations that should be offered to all children and adolescents undergoing an #alloHSCT. Read: astctjournal.org/article/S26…
1
1
299
The June issue of 'Transplantation and Cellular Therapy,' is now available online: astctjournal.org/current
@ELShematology
1
2
519
This study found that long-term survivors of #alloHCT experience excess morbidities compared with their siblings yet report similar quality of life. Younger survivors also reported superior mental health quality of life. Read the full study: astctjournal.org/article/S26…
3
310
This prospective phase II clinical trial shows that a novel FABT-based conditioning regimen achieved 100% neutrophil engraftment and 91.7% 2-year overall survival after haploidentical transplantation for severe aplastic anemia. Read more: astctjournal.org/article/S26…
3
5
635
This CIBMTR analysis of 938 children and young adults with #AML who underwent #alloHCT in remission found that extramedullary disease at diagnosis was not associated with adverse outcomes or increased relapse risk. Read more: astctjournal.org/article/S26…
1
3
322
This analysis of 408 alloBMT recipients shows that personalized desensitization effectively reduces donor-specific anti-HLA antibodies. Graft failure rates after desensitization were comparable to those with untreated low-level permissible DSAs. Read: astctjournal.org/article/S26…
2
9
811
This article provides a practical framework for developing cell and gene therapy programs across strategic operational financial and quality domains. The roadmap supports safe efficient and sustainable cell and gene therapies implementation. Read: ow.ly/qtBV50Z5OQe
3
441
This study shows that biogenic selenium nanoparticles enhance the antitumor efficacy of anti-mesothelin #CART cells in a syngeneic TNBC model. Combination therapy improved tumor suppression and favorably modulated the tumor microenvironment. Read more: ow.ly/VapY50Z5OOc
2
8
655
This review article highlights how regulatory T cells can suppress acute and chronic #GVHD while preserving graft-versus-leukemia effects after #alloHCT. Early clinical studies demonstrate promising GVHD control low relapse rates and favorable survival. ow.ly/U4PY50Z5OMO
10
28
1,194
The May issue of 'Transplantation and Cellular Therapy,' is now available online: astctjournal.org/current
@ELShematology
1
2
383
What fuels progress in chronic #GVHD research? Mentorship collaboration curious clinicians engaged patients and occasionally pizza. This reflection explores the relationships behind multidisciplinary transplant research. ow.ly/ubRt50Z2Yet
2
388
This perspective article shows that TBF conditioning for #alloHSCT offers potent disease control in acute leukemias and myeloproliferative neoplasms. Dose tailoring therapeutic drug monitoring and patient selection may mitigate toxicity. Read more: ow.ly/ZrwC50YYtGb
8
23
1,803
Competing risk analyses in #HCT and IEC research are frequently misconstrued. This practical guide outlines correct interpretation of competing risk methods and provides a step-by-step R tutorial for publication-ready analyses figures and tables. ow.ly/oCJ950YYtAZ
4
12
795
This study shows that GNRI CRP and disease status are independent prognostic factors after second allogeneic stem cell transplantation. A novel three-factor scoring system stratified survival outcomes and identified higher non-relapse mortality risk. ow.ly/lLkb50YYtwl
6
428
A study finds that decitabine (DAC) conditioning improved natural killer cell maturation and limited CD8 T cell terminal differentiation post-alloSCT. DAC conditioning potentially may improve graft-versus-tumor immunity in #AML patients. Full study: ow.ly/Ymn750YYtkO
1
2
12
867
CARE-BMT score predicts early cardiac events after #alloHCT and cyclophosphamide exposure increases risk. Modified model improves identification of cardiovascular risk and may guide cardioprotective strategies. Full article: ow.ly/QnyJ50YVi5Z
4
12
960
Low-dose azacitidine maintenance after #HCT is well tolerated in pediatric high-risk myeloid malignancies with 3-year OS 91% and RFS 73%. Favorable outcomes support prospective study. Read more: ow.ly/s2b250YVi5E
7
19
1,356
CNS chronic #GVHD manifests as vasculitis-like demyelinating or meningoencephalitic disease with 2.5% incidence and frequent response to immunosuppression. 8 of the 19 patients experienced long-lasting neurologic sequelae. Read more: ow.ly/WSHx50YVi5m
1
2
9
811
This prospective investigator-initiated clinical study shows that cytokine-induced killer cell infusion post-ASCT demonstrates antitumor activity with minimal toxicity enhances engraftment and T cell function in high-risk NHL: ow.ly/fhxc50YVi4U
1
4
351