☝️Atherosclerosis & Dementia: The Missing Link?
👉A new review reinforces a concept lipidologists and preventive cardiologists should not ignore: what damages arteries may also damage the brain.
1️⃣ Up to 45% of dementia cases may be preventable through modification of cardiovascular risk factors.
2️⃣ High LDL-C, elevated triglycerides, hypertension, type 2 diabetes, obesity, and smoking show the strongest evidence as causal risk factors for late-life dementia.
3️⃣ Genetic and Mendelian randomization studies increasingly support a role for apoB-containing lipoproteins in dementia risk, strengthening the vascular-brain connection.
4️⃣ Emerging evidence suggests that lipid-lowering therapies, particularly statins, may reduce dementia risk beyond cardiovascular protection.
5️⃣ The take-home message is simple: early prevention matters. By the time dementia becomes clinically apparent, decades of vascular and neurodegenerative injury may already have occurred.
🧠🤝❤️ What is good for the heart is good for the brain.
☝️Perhaps the strongest argument yet for aggressive lifetime management of LDL-C and overall cardiometabolic risk.
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atherosclerosis-journal.com/…
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