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The Thomas Group 🦖 @AThomasLab

We are a synthetic methods group at Texas A&M University. We use rapid injection NMR (RI-NMR) to study mechanisms and reactivity. Student ran account.

Joined September 2021
  • Tweets 313
  • Following 236
  • Followers 855
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The Thomas Group 🦖@AThomasLab
2 Dec 2025
Check out our newest paper out now in ACS Catalysis! Mechanistically Driven Development of Kumada Catalyst-Transfer Polymerizations: A Rapid Injection NMR Study | ACS Catalysis pubs.acs.org/doi/10.1021/acs…

Mechanistically Driven Development of Kumada Catalyst-Transfer Polymerizations: A Rapid Injection...

Transmetalation is a pivotal step in the Kumada–Tamao–Corriu cross-coupling reaction, yet its mechanistic details have remained relatively unexplored compared to other palladium-catalyzed processes....

pubs.acs.org
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The Thomas Group 🦖 retweeted
Boron-Chem-Research@Boron_Chemistry
Apr 15
Direct Access to Carbenoids from Alkyl and α-Acyloxy Halides for Boron Homologations ( @ChemRxiv ): chemrxiv.org/doi/full/10.264… ( @AThomasLab ).
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Check out our newest paper in Nature Communications where we developed a LED Rapid Injection NMR! nature.com/articles/s41467-0…

Design of a combined LED and rapid-injection NMR system for structure elucidations and kinetic...

Nature Communications - NMR spectroscopy is a powerful tool for studying chemical reactions, but short-lived intermediates are hard to capture. The authors present a system combining LED and...

nature.com
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The Thomas Group 🦖 retweeted
Lupita S. Aguirre@ls_aguirre
30 Jun 2025
Have you ever run a rxn using a gas reagent? Did you wish you could monitor it in real time? Now you can😎! Check out our new GRI-NMR system to monitor rxns using a continuous flow of a gas reagent at 1atm. ⁦⁩@AThomasLab⁩ ⁦@jeanettephos⁩ ⁦⁦⁦@ChemMethods⁩
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New Paper Alert! Congratulations to @ls_aguirre, @jeanettephos, and Raquel! Design of a Gas Rapid Injection Nuclear Magnetic Resonance System for Structure Elucidations and Kinetic Analyses - Aguirre - Chemistry–Methods - Wiley Online Library chemistry-europe.onlinelibra…

Design of a Gas Rapid Injection Nuclear Magnetic Resonance System for Structure Elucidations and...

A gas rapid injection nuclear magnetic resonance (GRI-NMR) device was designed and constructed for the precise delivery of gases at atmospheric pressures for real-time data acquisition. The GRI-NMR...

chemistry-europe.onlinelibrary.wiley.com
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The Thomas group has graduated PhD #3! Congratulations to Dr. Lupita Aguirre @ls_aguirre on a successful PhD defense! She will be heading west to the University of California-Los Angeles. Where she will join Prof. Osvaldo Gutierrez's lab as a Post Doc!
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The Thomas group has graduated PhD #2! Congratulations to Dr. Danniel Arriaga on an amazing defense. He will be taking his talents to the University of Wisconsin-Madison, where he will be working with Prof. Julian Cooper as a Post-Doc!
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The Thomas Group 🦖 retweeted
ChemEurJ: Chemistry - A European Journal@ChemEurJ
5 May 2025
Development of a Highly Selective Synthesis of 4-Substituted Tetrahydroquinolines: Substrate Scope and Mechanistic Study (Andy A. Thomas @AThomasLab and co-workers) #openaccess 🔓 onlinelibrary.wiley.com/doi/…

Development of a Highly Selective Synthesis of 4‐Substituted Tetrahydroquinolines: Substrate Scope...

A general and selective deprotonation capture sequence of tetrahydroquinolines with alkyl halides and aromatic halides at the 4-position using organolithiums and phosphoramide ligands is described....

chemistry-europe.onlinelibrary.wiley.com
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The Thomas Group 🦖 retweeted
J. Am. Chem. Soc.@J_A_C_S
1 Apr 2025
Future JACS authors from Texas A&M (D. Chattapadhyay, P. Castro Castro, L. Aguirre, S. Malavika, J. Pina, J. Nicholson) @TAMUChemistry @TAMU
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The Thomas group has graduated PhD #1! Congratulations to Dr. Jeanette Piña @jeanettephos on an amazing defense yesterday. She will be heading to Savannah River National Lab!
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New Paper Alert! Congrats to @jeanettephos, @ls_aguirre, Levi, Hi, and @CrockettChem! Development of a Highly Selective Synthesis of 4–Substituted Tetrahydroquinolines: Substrate Scope and Mechanistic Study - A European Journal - Wiley Online Library chemistry-europe.onlinelibra…

Development of a Highly Selective Synthesis of 4‐Substituted Tetrahydroquinolines: Substrate Scope...

A general and selective deprotonation capture sequence of tetrahydroquinolines with alkyl halides and aromatic halides at the 4-position using organolithiums and phosphoramide ligands is described....

chemistry-europe.onlinelibrary.wiley.com
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New Year New Paper! Congrats to @HanHsiang_Hsu, Seokmin, Cheng-Chun, and @MdRajaSk1994! Functionalization of Pyridines at the C4 Position via Metalation and Capture - Thomas - Angewandte Chemie International Edition - Wiley Online Library onlinelibrary.wiley.com/doi/…

Functionalization of Pyridines at the C4 Position via Metalation and Capture

n-Butylsodium can be used to selectively deprotonate pyridine at the C4 position, in sharp contrast to organolithium reagents which lead to nucleophilic addition at the C2 position. A wide range of...

onlinelibrary.wiley.com
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The Thomas Group 🦖 retweeted
Chemistry at Thieme
@thiemechemistry
3 Jan 2025
Interested in organolithium chemistry? Andy Thomas (@AThomasLab), @CrockettChem, @ls_aguirre, Shu-Kai Chen and Raja SK have compiled a #ScienceOfSynthesis review on practical advances in the application of Li in organic synthesis (Ed: Renzo Luisi @Luisi_Lab) @TAMUChemistry 🧐
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We are excited to share that our book chapter titled "Advances in Lithium Metal Sources: Synthesis and Applications." has been published in Science of Synthesis Knowledge Updates! Congratulations to @CrockettChem, @ls_aguirre, Shu-Kai and Raja! DOI: 10.1055/sos-SD-108-00398
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Our newest paper is available on ChemRxiv! Congrats to @jeanettephos, @ls_aguirre, Levi, Hai, and @CrockettChem! Development of a Highly Selective Synthesis of 4-Substituted Tetrahydroquinolines: Substrate Scope and Mechanistic Study | ChemRxiv - go.shr.lc/3CoHwoG

Development of a Highly Selective Synthesis of 4-Substituted Tetrahydroquinolines: Substrate Scope...

Herein, we describe a general and selective deprotonation functionalization reaction of tetrahydroquinolines at the 4–position using organolithiums and phosphoramide ligands. In addition to the...

chemrxiv.org
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The Thomas Group 🦖 retweeted
Organic Syntheses@OrgSynth
25 Oct 2024
Preparation of Highly Reactive Lithium Metal Dendrites and the Synthesis of (Trimethylsilyl)methyllithium Raquel M. Gonzalez, Han-Hsiang Hsu, and Andy A. Thomas @AThomasLab orgsyn.org/demo.aspx?prep=v1…
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Had an amazing time at the Welch conference! Congratulations to Prof. Eric Jacobsen on receiving the 2024 Robert A. Welch Award in chemistry! @WelchFoundation Shoutout Grandpa Buchwald @BuchwildGroup #buchwaldbowtie
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Enjoying a well-deserved break from the lab at the Renaissance Fair!
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Are you in need of (TMS)CH2Li and have some Li metal around the lab? 🤔 Look no further! Check out this Organic Syntheses Procedure on (TMS)CH2Li using Li-dendrites ❄️ Congrats to Raquel & Han-Hsiang! orgsyn.org/demo.aspx?prep=v1…
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Our reactions know it’s spooky season! 🦇👻🎃
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