Biomarker-guided duration of antibiotic treatment for sepsis
Joined November 2018
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15 Photos and videos
ADAPT-Sepsis retweeted
A simple blood test can tell doctors when it is safe to stop antibiotics in patients recovering from #sepsis, a review has found. The work supported by @NCAlliance_NHS & other GM organisations & co-authored by @darknatter is published in @Anaes_Journal
manchester.ac.uk/about/news/…
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28 Nov 2025
Cost effectiveness of PCT-guided antibiotic discontinuation explored link.springer.com/article/10…
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ADAPT-Sepsis retweeted
9 Sep 2025
Primary outcome @UKCCRGroup @AdaptSepsis . Safe reduction in antibiotics @DarkNatter #UKCCRF25
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ADAPT-Sepsis retweeted
9 Sep 2025
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15 Apr 2025
Delighted to have the chance to address important international discussions about @AdaptSepsis jamanetwork.com/journals/jam…
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ADAPT-Sepsis retweeted
25 Feb 2025
Editor’s choice from the February 25 issue.
➡️ Camrelizumab With Chemotherapy in Patients With Early or Locally Advanced TNBC
➡️ Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis
➡️ Essential Thrombocythemia: A Review; and more.
ja.ma/4hR14SI
#JAMA #MedicalResearch #ClinicalTrials
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ADAPT-Sepsis retweeted
24 Jan 2025
Thank you for this detailed review and comments. We @AdaptSepsis are working on trial process evaluation and health economic outcomes right now, so more to come to aid understanding of results. Hopefully, we will see you all @ICS_updates events in 2025 for further discussions
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ADAPT-Sepsis retweeted
9 Jan 2025
1/ Delighted to report the results of the Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH) trial in @LancetChildAdol thelancet.com/journals/lanch…
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ADAPT-Sepsis retweeted
13 Dec 2024
A major UK patient trial of a new biomarker testing protocol for sepsis, led by @OfficialUoM researchers, has shown it is possible to safely stop antibiotic treatment earlier than current care 🔬
@FBMH_UoM @DarkNatter
Read more about the trial 👇
manchester.ac.uk/about/news/…
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ADAPT-Sepsis retweeted
10 Dec 2024
@darknatter presents the results of the @AdaptSepsis trial results earlier today at @CCRdownunder
The paper has been published in @JAMA_current
jamanetwork.com/journals/jam…
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ADAPT-Sepsis retweeted
10 Dec 2024
Chief Investigator @darknatter shares the findings from the #ADAPTsepsistrial at #CCRdownunder
@adaptsepsis @FBMH_UoM @NIHRresearch @EPPiC_Warwick @NCAresearchNHS @JAMA_current
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ADAPT-Sepsis retweeted
9 Dec 2024
We are delighted to have contributed to this important trial. Because clinical research is how we improve the care we deliver. Thank you to our patients who took part. @AdaptSepsis @NCAresearchNHS @DarkNatter
9 Dec 2024
Published in JAMA with #CCRdownunder:
In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein.
@CritCareReviews
ja.ma/41t10TE
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ADAPT-Sepsis retweeted
9 Dec 2024
Fantastic work led by @darknatter and delivered by the phenomenal UK Critical Care community.
We can safely reduce antibiotic duration using procalcitonin (but not CRP).
@AdaptSepsis @WarwickCTU
9 Dec 2024
Published in JAMA with #CCRdownunder:
In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein.
@CritCareReviews
ja.ma/41t10TE
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ADAPT-Sepsis retweeted
26 Jun 2024
We're delighted to announce @AdaptSepsis as our first trial result presentation at #CCRdownunder
ADAPT-Sepsis is a 2760 patient RCT investigating biomarker-guided duration of antibiotic therapy in patients with sepsis
To be presented by @DarkNatter
criticalcarereviews.com/meet…
ALT Announcement of ADAPT-Sepsis trial results presentation at CCR Down Under in Melbourne in December
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ADAPT-Sepsis retweeted
26 Jun 2024
From Belfast to Melbourne - CCR Down Under is coming
The Best Critical Care Trials in the World
#CCRdownunder
criticalcarereviews.com/meet…
@intensiveblog @precordialthump @KBibbinsDomingo @giovannilandoni @GiacomoMonti @BaiardoMartina @anzicsctg @chodgsonANZICRC @DogICUma
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ADAPT-Sepsis retweeted
7 Jun 2024
Thrilled to hear that the @AdaptSepsis team have reached their recruitment target - well done everyone!
We're looking forward to comparing our process evaluation findings with your trial results in the coming months! cedar.nhs.wales/our-work/cli…
5 Jun 2024
Thank you to patient participants, families and carers for their generosity in taking part in the @AdaptSepsis research trial. We will now work hard with sites and investigators to complete data collection and report results as soon as possible @NCAresearchNHS @WCTU @FBMH_UoM
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ADAPT-Sepsis retweeted
7 Jun 2024
Congratulations, Paul, looking forward to the results!
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ADAPT-Sepsis retweeted
7 Jun 2024
Great work to all involved in completing recruitment to the @AdaptSepsis study. Thank you to our research team for their hard work in recruiting 85 of the number below! @NCAresearchNHS @OldhamCO_NHS
5 Jun 2024
Thank you to patient participants, families and carers for their generosity in taking part in the @AdaptSepsis research trial. We will now work hard with sites and investigators to complete data collection and report results as soon as possible @NCAresearchNHS @WCTU @FBMH_UoM
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