Scientist in the Hsu Lab, Arc Institute
Joined March 2021
- Tweets 11
- Following 105
- Followers 206
- Likes 32
Photos and videos
Alison Fanton retweeted
16 Nov 2025
Excited to share our new preprint!
How do animals transform internal representations into step-by-step navigation to goals? Decoding these strategies directly from behavior is challenging because these internal states are not directly observable.
biorxiv.org/content/10.1101/β¦
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8 Nov 2025
Thrilled to share our paper, now out in Nature Biotechnology! We engineered recombinases to enable efficient, specific genome insertion of multi-kb DNA cargoes at an endogenous locus. Grateful to all my amazing co-authors!
6 Nov 2025
A study published today in @NatureBiotech from the @pdhsu lab presents a new way to insert large DNA sequences into the genome using engineered recombinases that donβt require DNA cutting or rely on the cell's repair machinery.
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4 Nov 2024
𧬠Thrilled to share our latest work on engineering precise DNA recombinases for targeted genome integration! Through directed evolution & protein fusions, we achieved over 50% efficiency & 97% specificity for multi-kb DNA cargo insertions. Big thanks to all co-authors -
3 Nov 2024
π§΅In new work, we report a systematic engineering roadmap to optimize large serine recombinases (LSRs) for direct, site-specific insertion into the human genome π§¬. We achieved over 50% insertion efficiency and 97% genome-wide specificity, a 10X improvement over our previous work
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4 Nov 2024
especially @BartieLiam and @pdhsu , for your tireless teamwork and support. Itβs been a fun PhD!π©π»βπ¬
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Alison Fanton retweeted
31 Jan 2024
@cyrus_tau and I are so excited to share our work on developing a CRISPR protein-guided, trans-splicing system for making versatile RNA edits!!! See the highlights in Cyrus' thread and the preprint for details!
31 Jan 2024
.@sitaritapita and I are excited to share RESPLICE, a new RNA-programmable mode of editing that leverages RNA targeting CRISPR proteins and the endogenous spliceosomal machinery to enable versatile RNA edits in human cells! (1/12)
biorxiv.org/content/10.1101/β¦
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Alison Fanton retweeted
26 Jan 2024
Amazing week @KeystoneSymp ! So much fun to finally share our work. Itβs been an awesome scientific journey characterizing this system with @mgdurrant and our team
Some notes on our bridge recombination system from our preprint π§΅:
25 Jan 2024
Just shared at @KeystoneSymp a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts
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Alison Fanton retweeted
8 Nov 2021
By the way, if this flavor of molecular technology development excites you, we are hiring (at all levels)! Please reach out π©βπ»π§βπ»π©βπ¬π¨π»βπ¬
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Alison Fanton retweeted
7 Nov 2021
The ability of molecular biologists to control DNA has relied on enzymes derived from the phage-microbe arms race. In this new work, we systematically mined thousands of new serine integrases (LSRs) and developed them for human genome editing. π§¬
biorxiv.org/content/10.1101/β¦
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