@AnatomicTech profile picture
Anatomic Incorporated @AnatomicTech
Joined August 2019
  • Tweets 154
  • Following 259
  • Followers 147
95 Photos and videos
Sometimes morphology tells the story before the data does. High-purity RealDRG human iPSC-derived sensory neurons stained for ISL1 (white) and TUJ1 (red). This consistency helps make downstream assays more reproducible. #painresearch #iPSC #neuroscience #drugdiscovery
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📰From the Field: Gene supplementation for LBSL Annals of Neurology shows AAV9-DARS2 improves mitochondrial function and axonal growth in iPSC sensory neurons, with in vivo rescue Anatomic Senso-DM™ enabled patient sensory neuron modeling 🔗onlinelibrary.wiley.com/doi/…

AAV9‐DARS2 Gene Therapy Rescues Phenotype in Leukoencephalopathy with Brainstem and Spinal Cord...

Objective Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) is a rare, autosomal recessive disorder caused by variants in the gene DARS2. DARS2 is an...

onlinelibrary.wiley.com
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New protocol 🚨 Co-culture RealDRG™ sensory neurons with RealDHN™ dorsal horn neurons on the eNUVIO OMEGA4 to model functional pain circuits and sensory–spinal connectivity. Flexible workflow: use RealDRG™ alone or swap in your cell type of choice. #NotYourAverageNeuron
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Last weekend, Team Anatomic joined #Walk4CMT Minneapolis 💙 Proud to support an important cause, raise awareness, and help fund progress toward a cure. Thanks to everyone who walked with us and @cmtausa for organizing!
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NEW Human Trigeminal Neurons for #MigraineResearch! Phase-contrast images from our newest human iPSC-derived trigeminal neurons show high neuronal purity-no mitomycin C needed. Follow us for updates on functional characterization of migraine & pain targets #NotYourAverageNeuron
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🎥 A glimpse into our 7-day directed differentiation of human iPSC-derived dorsal horn neurons. Fast. Reproducible. Ready for pain pathway discovery. #NotYourAverageNeuron #CompleteTheCircuit #neuroscience #drugdiscovery #iPSC #dorsalhorn #painresearch
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Motor neurons alone can't explain ALS or CMT. Schwann Cell Precursors reveal how disrupted glial-neuronal crosstalk drives disease. Co-cultures model early pathogenesis, glial dysfunction, and myelination defects more accurately #CompleteTheCircuit #NotYourAverageNeuron
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Add These Publications to Your Reading List📚 Explore all publications featuring Anatomic’s products in one place-a fast way to find relevant assays & new applications See how our models are advancing discovery: anatomic.com/publications #CompleteTheCircuit #NotYourAverageNeuron
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The Kolber Lab at UTD has launched a core facility featuring a high-content screening assay for analgesic discovery using the Axion BioSystems Maestro Pro, now featured in their latest publication Read the article here: cell.com/cell-reports-method…

Profiling human iPSC-derived sensory neurons for analgesic drug screening using a multi-electrode...

Fofie et al. present a high-content screening platform using hiPSC-derived nociceptors cultured on multi-well multielectrode arrays to identify peripheral analgesics with diverse mechanisms of...

cell.com
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Team Anatomic hit the pavement together for the #Walk4CMT 💙 Grateful to be part of a community that's raising awareness, showing support, and walking toward a cure. Huge to @cmtausa for putting on a well organized and meaningful event!
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Keepin it local🤙🏼Attended the 3rd MN Organoid Symposium put on by the @umnmedschool & @MayoClinic earlier this week. Big shoutout to our Scitech intern Devanshi who gave her first poster presentation! Reach out to learn more about applications in this space➡️support@anatomic.com
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🌉Vince will be speaking at the @AxionBioSystems World Tour: San Francisco User Group Meeting on April 17, 2025! 🎤“Completing the Circuit: Advanced hiPSC-Based Models of the Peripheral Nervous System for Disease Modeling and Drug Discovery" 🔗Register axionbiosystems.com/axion-wo…
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💡 Enhance your research! Integrate Schwann cell precursors (SCPs) into your motor neuron (MNs) cultures As SCPs mature, they migrate & align along axons, visualized using immunofluorescent staining—S100b/SOX10 (SCPs) & TUJ1 (MNs) #CompleteTheCircuit #ALSResearch
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💎Check-out the purity💎 Images of RealDHN hiPSC-derived dorsal horn neuron cultures, generated without the need for genetic engineering or Mitomycin C treatment Visit anatomic.com/realdhn for more info on the molecular and functional characterization of the neurons!
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Anatomic has been focused on developing CIPN-related assays for the last few years. The FDA’s new draft guidance underscores the need for better study designs and endpoints in CIPN research. Read the full guidance below! #CompleteTheCircuit #CIPNResearch
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💎Check-out the purity💎 Images of co-cultures of RealSCP, hiPSC-derived Schwann cell precursors, and RealDRG, hiPSC-derived sensory neurons, generated without the need for genetic engineering or Mitomycin C #CompleteTheCircuit #NotYourAverageNeuron
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It’s always tough to pick favorites when there’s so much exciting data to explore! 🤩 We have compiled our favorite data from over the years onto a new page for your easy access Check out our data highlights page at: anatomic.com/datahighlights
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Harnessing a more physiological in vitro model for CIPN! Dr. Nanna Elman Andersen’s Ph.D. thesis explores chemotherapy-induced neurotoxicity using hiPSC-derived Schwann cells & sensory neurons, studying paclitaxel, vincristine & bortezomib portal.findresearcher.sdu.dk…

Mechanisms of chemotherapy neurotoxicity in iPSC-derived schwann cells and sensory neurons

portal.findresearcher.sdu.dk
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Science is serious stuff, but sometimes it can’t help but make you smile. Especially when it smiles first 😁
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🧒🏻👧🏽👦🏼👩🏽‍🦱Multiple donors. Same process. Sensory neurons derived from hiPSC lines (both healthy and diseased) express key ion channel targets for pain - NaV1.7, NaV1.8, and TRPV1 #NotYourAverageNeuron #CompleteTheCircuit #DiseaseModeling #PainResearch
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