MitotypeExplorer: an interactive web resource to explore mitochondrial molecular diversity in different tissues and under diverse experimental conditions

Grateful to work with so many talented and passionate people to build the foundation for how we think about mitochondria, energy, health, and healing Kudos @AnnaMonzel for coming up with the "motherboard" analogy Thank you @janellison scientificamerican.com/artic…

Such a fun project! I enjoyed processing and mitotyping the single nuclei RNAseq data. Chapeau to Eugene, Ayelet, @MichelTdS, @MitoPsychoBio and all co-authors for creating the first MitoBrainMap 👏

🧠 Just out in Nature: A human brain map of mitochondrial diversity. A powerful collaboration with Mosharov and @MitoPsychoBio. Big step toward bridging cell biology and neuroimaging! 🔗 nature.com/articles/s41586-0… 🧬 #MitoBrainMap #neuroscience

All mitochondria in your body comes from the same "mother" population in the egg/oocyte, later differentiating into distinct mitochondrial phenotypes or "mitotypes" (like cell types) In the end, we are made of dozens of different specialized mitotypes New preprint where @AnnaMonzel quantifies how different mitochondrial populations are in different organs and tissues, and within the same cell type exposed to different challenges over several months biorxiv.org/content/10.1101/…

Well. It REALLY happened. The plagiarized paper got published. my paper from 2021 - pubmed.ncbi.nlm.nih.gov/3391… new one from 2024 - pubmed.ncbi.nlm.nih.gov/3870… We'll look at figures in the 🧵 below.

Psilocybin's powerful short- and long-term effects on your brain are revealed by this intrepid precision imaging drug trial published in @Nature. As one of the scientists I was also a study volunteer. Spending hours in an MRI scanner, while tripping on 25 mg was the experience of a lifetime. Ever since, it's fascinated me that I can remember all of it, even though my thoughts were massively distorted. I took notes afterwards and turned them into a story ... given the interest, I'll try to publish it somewhere. Study: nature.com/articles/s41586-0… NPR coverage: npr.org/sections/shots-healt…

So important!

Such great work!

Is brain mitochondrial biology linked to our positive and negative psychosocial experiences? @CarolineTrumpff looked into this question using a brain multi-omic postmortem dataset from individuals who reported their subjective experiences yearly until they died.

What is the Integrated Stress Response (ISR) ?

#NewIssue On the cover: In this issue of Cell Metabolism, Li et al. reveal that sick neurons release lipids to the glia, causing lipid droplet accumulation and neuroinflammation. The artwork, inspired by Van Gogh's Starry Night, depicts a brain with lipid droplets. Artwork by Melody Hui. Read the paper: cell.com/cell-metabolism/abs…

Why are transitions always difficult? Whether a conscious, thinking, feeling organism; or a single cell; life transitions are always hard because they cost energy. We discuss the energetic cost of transitions, the ISR, and GDF15: academic.oup.com/lifemeta/ar…

Perspective: ISR is an energetic checkpoint evolved to prevent OxPhos-deficient cells from engaging in excessively costly transitions, and allow ISR-positive cells to recruit systemic energetic resources.academic.oup.com/lifemeta/ad…

Such an amazing resource for the world of mitochondria!

Bravo!! Amazing work @n_bobba_alves , @MitoPsychoBio, and all co-authors!

Thank you so much of being part of #Euromit2023 ! We hope you enjoyed it ! See you at the next mito conference !

Inspiring closing lecture by @AWartiovaara @Euromit2023

Columbia University family at #euromit2023

Online now! Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction dlvr.it/Sn6VKR