📣 📖 Proud to share our latest publication in Frontiers-Medicine
#Nephrology:
🧬’
#ApolipoproteinL1 (
#APOL1) genetic testing, family history of hypertension, and kidney disease in a Midwestern U.S. cohort’
This study examined the intersection of
#APOL1genetic risk, family history, and kidney health among Black adults participating in the
#StLouisAPOL1 cohort study.
🔹 Among 220 participants who underwent APOL1 genotyping, we found that APOL1 high-risk genotypes were more common among individuals with a family history of hypertension and/or kidney disease, greater antihypertensive medication burden, lower kidney function, albuminuria, and early decline in eGFR.
🔹 Importantly, the findings highlight that genetic risk and family history provide overlapping—but not identical—information about kidney disease susceptibility. Together, these observations reinforce the need for integrated approaches that combine genetics, clinical assessment, and family history to improve kidney disease risk stratification and early identification of individuals at increased risk.
🌟 What makes this publication especially meaningful is the extraordinary collaboration behind it.
This work brought together investigators from SSM Health Saint Louis University Hospital, Saint Louis University School of Medicine, Mid-America Transplant, UCSF Department of Medicine, Wake Forest University, and the multidisciplinary
#StLouisAPOL1StudyCollaborators. The project reflects the collective efforts of nephrologists, genetic researchers, epidemiologists, biostatisticians, research nurses, and community partners committed to advancing kidney health equity.
🖋️Authors include:
@renginels |
@AlizaAnwarMemo1 |
@KanaHelloKidney |
@Barisafsar75 |
@AmberCarriker |
@AbualrubFadee |
@yasar_caliskan |
@SSMHealthSTL |
@SSMHealth |
@UCSFNephrology |
@wakeforestmed |
@slusom
🤝🏽 St. Louis APOL1 Study Collaborators include:
@AvaDelonai6124 |
@HoujeijNourhan |
@nephrom |
@drrushdafaruk |
@MowaffaqSaid
🙏🏽We are grateful for the support of
#MidAmericaTransplant, whose commitment to innovation, research, and collaboration continues to advance understanding of kidney disease risk and opportunities for prevention.📊
This study represents another important step toward understanding how genetic and familial factors can be incorporated into more precise, patient-centered approaches to kidney disease prevention and care.
📖 🆓 Open Access:
doi.org/10.3389/fneph.2026.1…
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#APOL1 #KidneyDisease #Nephrology #Genetics #PrecisionMedicine #ChronicKidneyDisease #KidneyHealth #ResearchCollaboration #Multidisciplinary #PublicHealth #FrontiersInNephrology 🩺