A full-stack institute for AI and biology research.
Joined November 2021
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285 Photos and videos
Jun 10
Arc’s Virtual Cell Initiative focuses on the full-stack development of an accurate AI model to advance complex disease research. At TED2026, Executive Director @SKonermann joined @TEDchris to talk about what we’re building.
ted.com/talks/silvana_konerm…
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May 29
The brain works hard to clear waste, and impairments are central to neurodegeneration. In @CellCellPress, Innovation Investigator @andcyang, w/ @NaliniRRao, Yuichi Chayama, and team map it from the inside out, following the brain's own proteins to see where waste actually goes.
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May 29
Disease disrupted clearance in two ways:
LPS-driven inflammation broke down the blood-brain barrier, shunting Syn-ZsG away from borders and into the blood.
In 5XFAD mice, amyloid pathology had the opposite effect, trapping proteins in the brain, with less reaching the brain borders as amyloid levels rose.
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May 29
While 'waste' is shorthand, thousands of proteins the brain sheds aren't inert junk; many likely signal to the immune system. Systematic study of brain clearance opens paths to rejuvenate it as an upstream target for neurodegeneration.
Access the paper: cell.com/cell/fulltext/S0092…
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May 26
Most spatial CRISPR screens require trade-offs in throughput or readout depth. A new preprint from @alexnevue, @Inna_Averbukh, @Davidlarastiaso & team introduces PerturbSpace: spatially resolved, multimodal, whole-transcriptome on standard single-cell workflows.
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May 26
PerturbSpace turns non-cell-autonomous effects from a niche capability into a systematic readout, producing the tissue-scale perturbation data needed to inform virtual cell models.
Explore the full paper here: biorxiv.org/content/10.64898…
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May 26
Listen to a preview of PerturbSpace from first author @alexnevue:
youtube.com/watch?v=SNzdo8r7…
Or go behind the scenes of the paper in this blog post: arcinstitute.org/news/pertur…
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May 15
Introducing the inaugural cohort of the Arc AIxBio Fellows. These five student teams will each tackle an ambitious ML project over the next 6-12 months with a dedicated mentor.
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May 15
See the full announcement from program organizer @genophoria: arcinstitute.org/news/aixbio…
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May 15
Interested in being a future fellow? 2027 applications open in January. Follow Arc for updates or learn more about the program: arcinstitute.org/programs/ai…
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