Research and development company leveraging the biology of diverse organisms. Read about our science: research.arcadiascience.com

Joined July 2021
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Whether you’re performing phylogenomic inferences, identifying structural differences and similarities between proteins, or doing high-throughput time-lapse imaging, we have some free, easily accessible tools and resources that may be helpful for you. 🧵
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Come help scale this and other raman tools! Product Lead role now open: jobs.lever.co/arcadiascience…

AI agent loop controlling our automated Raman microscope - from acquisition to stage movement to online analysis. It does a quick scan, then re-acquires spots with the best signal, and finally finds the most distinct spot and does an in-depth acquisition @ArcadiaScience
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Arcadia Science retweeted
🚨New job alert! I’m looking for a strong scientist and operator that wants to expand their efforts to work closely with me on … well everything! This spans my work at @ArcadiaScience as well as @AsteraInstitute. If you’re excited by the mission of our orgs, thrive in a fast-paced environment, and have a passion for science/open science/metascience, apply now! jobs.lever.co/arcadiascience…
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Arcadia Science retweeted
Job alert! Biology needs faster, cheaper, non-destructive ways to measure phenotypes across molecular & cellular scales. @ArcadiaScience we're psyched about what's possible w raman spectroscopy. New role to scale raman hardware/analysis as part of our new tools foundry👇
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🚨new job alert! If you’ve been following our efforts @ArcadiaScience, you know we’re very into high-dimensional phenotyping and think Raman spectroscopy is under-applied to biology. If you want to help us productionize our prototypes so others can benefit, join us! jobs.lever.co/arcadiascience…

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New pub from @ArcadiaScience 🧵 We found that C. smithii — a freshwater green alga — undergoes wild morphological transformations when grown on Marine Broth. Huge cells with mysterious wisp-like appendages. Here's what we saw. thestacks.org/publications/o… [1/9]
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Big day! We just dropped our 100th🎉 publication @ArcadiaScience! Check out our latest👇 Our first coherent Raman spectroscopy dataset in live fission yeast at subcellular resolution thestacks.org/publications/d… An evolution-informed bioprospecting framework to facilitate mining the tree of life for bio-utility thestacks.org/publications/p… A Bayesian strategy for collecting biological data to maximize information gain thestacks.org/publications/i…
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1/6 We published a deep dive into what MSA Pairformer learns about evolutionary relationships. @yoakiyama et al. achieved impressive contact and variant fitness prediction with a fraction of ESM2's parameters; we wanted to understand the mechanism better. tinyurl.com/4ccn397z
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’Tis the season to be green 🌲 Our latest organism spotlight is Chlamydomonas reinhardtii — a tiny algae with a long history of punching above its weight in scientific discovery. Happy holidays! youtube.com/watch?v=cUscLHNV…
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This spotlight is the second short video in our series highlighting organismal models. The first was on sea squirts: x.com/seemaychou/status/1952…

Replying to @seemaychou
Most importantly, first in our new series of organismal spotlight shorts (open source illustrations coming soon!). Sea squirts! youtube.com/watch?v=-E9Te1Ks…
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We also released a free organism illustration library sharing high quality CC0 illustrations of 70 organisms & viruses (including chlamy and sea squirts): x.com/thecrispress/status/19…

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How to transform UMAP from a black box into a glass box: by using a special type of deep network, we can now compute exact linear equivalents that reveal which features drive each point's position in the embedding. @ArcadiaScience [1/8]
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10 Sep 2025
Introducing AutoOpenRaman, an automated, inexpensive microscope for Raman spectroscopy! 🧵 We recapitulated many features of expensive commercial systems using economical hardware and open-source software. @ArcadiaScience research.arcadiascience.com/… [1/8]
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Arcadia Science retweeted
Right now is the best chance the scientific community has ever had to end the artificial scarcity of academic journals. Check out my new op-ed urging @NIH @NIHDirector_Jay to disallow taxpayer dollars towards journal publication fees — something both publishers and scientists have played a role in perpetuating. The last day for public comment on this topic is Monday, Sept 15. It’s time to unleash science. Links in 🧵
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18 Aug 2025
we recently did our biggest icebox so far @ArcadiaScience -- we made the call to wind down our first/longest running start-up Trove. read about why & what we learned (and technical resources we released!). Quick 🧵👇 research.arcadiascience.com/…
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15 Aug 2025
Are you an ML researcher/engineer hoping to learn frontier biology? We’re looking for folks @ArcadiaScience to help build quantitative bio models w us. Our quest: find the MVP bio data required if it’s structured by evolution. Come for a stint to dig in! jobs.lever.co/arcadiascience…

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