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β-arrestin Bot @ArrestinBot

I am a bot that tweets new papers about β-arrestin as they are published to #PubMed!

Joined March 2019
  • Tweets 1,436
  • Following 5
  • Followers 729
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Differential regulation of histamine H1 receptor-mediated ERK phosphorylation by Gq proteins and arrestins pubmed.ncbi.nlm.nih.gov/3720… #GPCR #signaling #pharmacology

Differential regulation of histamine H1 receptor-mediated ERK phosphorylation by Gq proteins and...

Gq protein-coupled histamine H1 receptors play crucial roles in allergic and inflammatory reactions, in which the phosphorylation of extracellular signal-regulated kinase (ERK) appears to mediate the...

pubmed.ncbi.nlm.nih.gov
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Correction to "Cannabinoid Tolerance in S426A/S430A x β -Arrestin 2 Knockout Double-Mutant Mice" pubmed.ncbi.nlm.nih.gov/3719… #GPCR #signaling #pharmacology

Correction to "Cannabinoid Tolerance in S426A/S430A x β-Arrestin 2 Knockout Double-Mutant Mice" -...

Correction to "Cannabinoid Tolerance in S426A/S430A x β-Arrestin 2 Knockout Double-Mutant Mice"

pubmed.ncbi.nlm.nih.gov
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Detection, chemical analysis, and pharmacological characterization of dipyanone and other new synthetic opioids related to prescription drugs pubmed.ncbi.nlm.nih.gov/3717… #GPCR #signaling #pharmacology

Detection, chemical analysis, and pharmacological characterization of dipyanone and other new...

The emergence of structurally diverse new synthetic opioids (NSOs) has caused the opioid crisis to spiral to new depths. Little information is available about the pharmacology of most novel opioids...

pubmed.ncbi.nlm.nih.gov
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Distinct Profiles of Desensitization of µ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses pubmed.ncbi.nlm.nih.gov/3717… #GPCR #signaling #pharmacology

Distinct Profiles of Desensitization of µ-Opioid Receptors Caused by Remifentanil or Fentanyl: In...

Remifentanil (REM) and fentanyl (FEN) are commonly used analgesics that act by activating a µ-opioid receptor (MOR). Although optimal concentrations of REM can be easily maintained during surgery, it...

pubmed.ncbi.nlm.nih.gov
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Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy pubmed.ncbi.nlm.nih.gov/3716… #GPCR #signaling #pharmacology

Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy - PubMed

The μ-opioid receptor (μOR) is an important target for pain management and the molecular understanding of drug action will facilitate the development of better therapeutics. Here we show, using...

pubmed.ncbi.nlm.nih.gov
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Plasma membrane preassociation drives β-arrestin coupling to receptors and activation pubmed.ncbi.nlm.nih.gov/3714… #GPCR #signaling #pharmacology

Plasma membrane preassociation drives β-arrestin coupling to receptors and activation - PubMed

β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the...

pubmed.ncbi.nlm.nih.gov
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A novel CCR6 antagonist (PF-07054894) that distinguishes between homologous chemokine receptors, increases basal circulating CCR6 T cells, and ameliorates interleukin-23-induced skin inflammation pubmed.ncbi.nlm.nih.gov/3714… #GPCR #signaling #pharmacology

A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894)...

Blocking chemokine receptor C-C chemoattractant cytokine (chemokine) receptor (CCR) 6-dependent T cell migration has therapeutic promise in inflammatory diseases. PF-07054894 is a novel CCR6 antago...

pubmed.ncbi.nlm.nih.gov
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Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice pubmed.ncbi.nlm.nih.gov/3713… #GPCR #signaling #pharmacology

Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arre...

The glucagon-like peptide-1 receptor (GLP-1R) is a major type 2 diabetes therapeutic target. Stimulated GLP-1Rs are rapidly desensitized by β-arrestins, scaffolding proteins that not only terminate G...

pubmed.ncbi.nlm.nih.gov
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Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model pubmed.ncbi.nlm.nih.gov/3712… #GPCR #signaling #pharmacology

Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase...

We present the synthesis and characterization of merged human butyrylcholinesterase (hBChE) inhibitor/cannabinoid receptor 2 (hCB2R) ligands for the treatment of neurodegeneration. In total, 15...

pubmed.ncbi.nlm.nih.gov
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Sex-dependent effects of acute stress on amyloid-β in male and female mice pubmed.ncbi.nlm.nih.gov/3712… #GPCR #signaling #pharmacology

Sex-dependent effects of acute stress on amyloid-β in male and female mice - PubMed

The risk of developing Alzheimer's disease is mediated by a combination of genetics and environmental factors, such as stress, sleep abnormalities and traumatic brain injury. Women are at a higher...

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Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells pubmed.ncbi.nlm.nih.gov/3712… #GPCR #signaling #pharmacology

Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells - PubMed

G protein-coupled receptors (GPCRs) are the largest superfamily of human membrane target proteins for approved drugs. GPCR ligands can have a complex array of pharmacological activities. Among these...

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Carteolol triggers senescence via activation of β-arrestin-ERK-NOX4-ROS pathway in human corneal endothelial cells in vitro pubmed.ncbi.nlm.nih.gov/3712… #GPCR #signaling #pharmacology

Carteolol triggers senescence via activation of β-arrestin-ERK-NOX4-ROS pathway in human corneal...

Carteolol is a commonly-used topical medication for primary open-angle glaucoma. However, long-term and frequent ocular application of carteolol entails its residuals at low concentration in the...

pubmed.ncbi.nlm.nih.gov
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A 5-year-old Syrian female was born with Oguchi disease: a rare case report pubmed.ncbi.nlm.nih.gov/3711… #GPCR #signaling #pharmacology

A 5-year-old Syrian female was born with Oguchi disease: a rare case report - PubMed

Optical coherence tomography is of great importance in Oguchi's disease. Optical coherence tomography usually shows an absence of the inner and outer segments line in the extrafoveal area during a...

pubmed.ncbi.nlm.nih.gov
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Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking pubmed.ncbi.nlm.nih.gov/3710… #GPCR #signaling #pharmacology

Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and...

The selectivity of drugs for G protein-coupled receptor (GPCR) signaling pathways is crucial for their therapeutic efficacy. Different agonists can cause receptors to recruit effector proteins at...

pubmed.ncbi.nlm.nih.gov
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Identification of biomarkers, pathways, and potential therapeutic targets for heart failure using next-generation sequencing data and bioinformatics analysis pubmed.ncbi.nlm.nih.gov/3709… #GPCR #signaling #pharmacology

Identification of biomarkers, pathways, and potential therapeutic targets for heart failure using...

This discovery-driven study might be useful to provide a novel insight into the diagnosis and treatment of HF. However, more experiments are needed in the future to investigate the functional roles...

pubmed.ncbi.nlm.nih.gov
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Regulation of the pro-inflammatory G protein-coupled receptor GPR84 pubmed.ncbi.nlm.nih.gov/3708… #GPCR #signaling #pharmacology

Regulation of the pro-inflammatory G protein-coupled receptor GPR84 - PubMed

GPR84 is an understudied rhodopsin-like class A G protein-coupled receptor, which is arousing particular interest from a therapeutic perspective. Not least this reflects that gpr84 expression is...

pubmed.ncbi.nlm.nih.gov
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Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival pubmed.ncbi.nlm.nih.gov/3707… #GPCR #signaling #pharmacology

Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival - PubMed

5-Hydroxytryptamine receptor 1E (5-HTR1E) is reported to activate cyclic AMP (cAMP) and extracellular-signal related kinases (ERK) pathways via its ligands and binding partners, but the detailed...

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Subcellular location defines GPCR signal transduction pubmed.ncbi.nlm.nih.gov/3707… #GPCR #signaling #pharmacology

Subcellular location defines GPCR signal transduction - PubMed

Intracellular G protein-coupled receptors (GPCRs) can be activated by permeant ligands, which contributes to agonist selectivity. Opioid receptors (ORs) provide a notable example, where opioid drugs...

pubmed.ncbi.nlm.nih.gov
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ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis pubmed.ncbi.nlm.nih.gov/3706… #GPCR #signaling #pharmacology

ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis -...

In sexual reproduction, sperm contribute half the genomic material required for creation of offspring yet core molecular mechanisms essential for their formation are undefined. Here, the α-arrestin...

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Computational insights into ligand-induced G protein and β-arrestin signaling of the dopamine D1 receptor pubmed.ncbi.nlm.nih.gov/3706… #GPCR #signaling #pharmacology

Computational insights into ligand-induced G protein and β-arrestin signaling of the dopamine D1...

The dopamine D1 receptor (D1R), is a class A G protein coupled-receptor (GPCR) which has been a promising drug target for psychiatric and neurological disorders such as Parkinson's disease (PD)....

pubmed.ncbi.nlm.nih.gov
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