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Joined April 2018
65 Photos and videos
First structure of a H/ACA snoRNP acting in ribosome synthesis. In a great collaboration with the Hurt lab, we provide a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. πŸ‘‡πŸ‘‡πŸ‘‡
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Beckmann Lab retweeted
Authors including @jingdongcheng report cryo-EM structures revealing how antibiotic tigecycline can also target human mitoribosome. nature.com/articles/s41467-0…
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Fresh out of the oven, our collaboration with the Kopito Lab - UFL1(E3) modifies, binds to, and dissociates the 60S subunit from the Sec61 translocon! #ribosome #cryoEM
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Check out the the full story here: nature.com/articles/s41586-0…

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Also check out the paper by @zeqiraj and @YKulathu: nature.com/articles/s41586-0…
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πŸŽ‰We are thrilled to share our exciting new collaboration with @inada_lab and @jingdongcheng on how Otu2 recognizes and deubiquitinates 40S ribosomes after translation. Here is a thread with the most interesting findings:πŸ‘‡ #ribosome #ubiquitin #cryoEM
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Otu2 can bind to 40S during cytoplasmic ribosome biogenesis and all stages between ribosome recycling and start-codon recognition, but becomes a highly specific enzyme for translational reset during recycling/(re)initiation by removing mono-ubiquitin present on eS7.
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Beckmann Lab retweeted
Turns out MutS2 just doesn’t cut it βœ‚οΈ despite it having an SMR domain! Our latest collaboration with the @BeckmannLab characterizing the role of MutS2 in splitting stalled ribosomes in B. subtilis. biorxiv.org/content/10.1101/…
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Beckmann Lab retweeted
Let's rotate! Thanks to the great Hurt lab and @BeckmannLab, our story on the 60S ribosome biogenesis is finally out in EMBO reports. We find the 5S RNP in a new rotate conformation when stably incorporate into the nucleolar pre-60S. #cryoEM #ribosome doi.org/10.15252/embr.202356…
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Keeping up the momentum, we're excited to share the final version of our story about RQT-driven ribosomal splitting πŸŽ‰ πŸŽ‰ Shout out to @KaBe__01, @ThomasB08006066, @inada_lab and everyone involved! Read on to learn moreπŸ‘‡πŸ»πŸ‘‡πŸ»πŸ‘‡πŸ» #cryoEM #ribosome #RQT
Pull the ripcord to clear the traffic jam: RQT splits collided #ribosomes by engaging the emerging mRNA. Check out our new story at #bioRxiv: biorxiv.org/content/10.1101/…
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The Ski2-like helicase 1 subunit applies a pulling force on the mRNA which causes RQT to swivel between two conformations. This leads to the destabilization of the 40S subunit, resulting in subunit dissociation of the leading ribosome.
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Check the full story here πŸ‘‰πŸ»πŸ‘‰πŸ»πŸ‘‰πŸ»nature.com/articles/s41467-0…

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