Kellyanne: Is there any number of scandals that would make you stop? Putting on with women that are not your wife? Would it be the lying? Would it be insulting heroes? Is power really worth that to you?

JD Vance: "I don't know why Democrats can't just find normal, well-adjusted candidates"

RAJU: But what evidence is there to prove the California election is rigged? MIKE JOHNSON: Look, some of these efforts are so diabolical and so far upstream it's impossible to prove. But I think everybody knows instinctively that something is wrong here.

Ok I hate the “stolen election” stuff from the president BUT why keep asking him? It’s not exactly news that he thinks it’s stolen. The question seems performative, merely to elicit the reaction he delivered

WOW -- Trump crashes out and cuts his interview with Welker short as she presses him on his lack of evidence for claiming elections are rigged "You're either crooked or you're stupid. Let's call it quits. Because I've had enough. Thank you darling," he tells her." "I traveled all the way to Wisconsin for this interview," she pleads.

🤯 JUST IN: INCREDIBLE PHASE 3 DATA ON RETATRUTIDE PRESENTED AT ADA At ADA this weekend, Eli Lilly ($LLY ) presented new Phase 3 data from TRIUMPH-1 and TRANSCEND-T2D-1. BLUF: 28% (70 pounds) weight loss. Unreal. In TRIUMPH-1, participants receiving 12 mg of retatrutide lost an average of 70.3 pounds (28.3%) over 80 weeks. Nearly half achieved at least 30% weight loss, and 65.3% were no longer classified as obese (BMI <30) by the end of the study. Among participants who started with BMI ≥35 and continued treatment to 104 weeks, average weight loss reached 85 pounds (30.3%), with no evidence that weight loss had fully plateaued. What stood out more was the breadth of effect across obesity-related conditions: Knee osteoarthritis pain improved by 73.1% Obstructive sleep apnea severity improved by 60.6% Triglycerides fell by as much as 41.0% Non-HDL cholesterol declined by 24.2% Systolic blood pressure dropped by 12.3 mmHg Waist circumference decreased by 9.5 inches Meanwhile, in TRANSCEND-T2D-1, retatrutide produced A1C reductions of up to 2.0% from a baseline of 7.9%. 90% of patients achieved A1C <7% 85% achieved A1C ≤6.5% 46% reached A1C <5.7%, which is below the threshold used to define prediabetes Patients lost 36.6 pounds (16.8%) at 40 weeks, and weight loss was still ongoing at study end. Obesity medicine is increasingly becoming outcomes medicine. Historically, we have evaluated obesity drugs primarily on percent weight loss... but payers ultimately care about sleep apnea, osteoarthritis, diabetes, cardiovascular risk, and healthcare costs. The significance of TRIUMPH-1 and TRANSCEND-T2D-1 is that Lilly is beginning to show a coherent story across those endpoints, not just body weight. I expect this to expand coverage dramatically. Eli Lilly is the Nvidia of healthcare.

Contempt for white people is the glue that holds the Democrat Party together.

Energy Secretary Chris Wright: "Solar is irrelevant in the winter" (this, dear reader, is false)

it's unclear if most ppl realize that ozempic’s real effects on culture haven’t even started. cuz what you’re seeing now is the first order effects & some glimpses of second order where ppl get thinner & some products experiencing a resurgence. but the second & third order effects are where things might get gnarly due to the fact that these drugs seem to dampen desire itself across a surprisingly wide range of behaviors (it's not universal or obvious yet). food is simply the first & most obvious target. liek what happens when millions of people suddenly spend less time thinking about consumption? what happens to industries built around cravings, indulgence, impulse purchases, addiction loops, or even certain forms of entertainment? entire sections of the economy assume humans will remain governed by the same reward circuitry we’ve had for thousands of years. if these drugs meaningfully alter those circuits, we’re talking about a tool that edits human motivation. we are gonna see thinness but in a lot of diff ways it seems like.

This is actually insane. 97% of people taking the standard of care for metastatic solid tumor got worse by seven years. But with lorlatinib, that number was only 45% in the same time! This is an ENORMOUS jump in the quality of cancer care.

Trump: "We shouldn't have been in Iran"

This is wild. Why does an American need twice as much energy as an average European?

Had Trump endorsed Cornyn then Paxton still would have won by a lot. That’s why Trump did not endorse Cornyn.

Teachable moment: Most people - even fierce critics of COVID policies - agree that truly sick people (or high-risk exposures) should isolate to protect the public (by law if needed). The rub with COVID? A ~50% asymptomatic rate meant half of infected people felt (and looked) totally fine. No one knew they were “sick.” In most of 2020, the core problem wasn’t about policy. It was the lack of rapid, widespread testing, so we could truly identify the healthy vs the infected. 🤔