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Bhandoola_Lab @Bhandoola_Lab

As a lab, we're all in.

Joined February 2024
  • Tweets 21
  • Following 43
  • Followers 25
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Arundhoti Das' review on ILC development was published, shortly after she started her own lab. Yi Ding and Christelle Harly are co-authors. nature.com/articles/s41590-0…

The development of innate lymphoid cells

Nature Immunology - In this Review, Bhandoola et al. discuss recent advances in understanding early developmental stages of innate lymphoid cells originating from lymphoid progenitors in mice.

nature.com
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cell.com/immunity/abstract/S… NFIL3 resides at the apex - as far as I know, at least - of a transcription factor hierarchy that initiates innate lymphoid specification.

The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors

Understanding the mechanisms underlying innate lymphoid cell (ILC) specification may provide insight into ILC functions in immunity and tissue homeostasis. Léger et al. demonstrate that NFIL3...

cell.com
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Much to add. Two long obsessions, finally published last year. First, this one: journals.plos.org/plosbiolog… Is thymic involution consequential for immune responses? If you could figure out how to prevent it, or reverse it, would it matter?

Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice

Age-related thymic decline impairs T-cell immunity and increases infection risk in the elderly. This study shows that enhancing thymic function in aged mice restores naïve T cells and improves immune...

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Our colleagues will of course decide whether the new NK classification proposed by @EricVivier1 is useful. What their decision, I do think a classification that makes sense of both mouse and NK subsets would be very useful to the field.
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Our contribution was to show that mouse NK cells develop by 2 pathways, and that the transcriptional signatures that defined these 2 mouse NK subsets also distinguished human NK subsets defined by CD56.
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Glad to have contributed to the work by Rebuffet, @EricVivier1 and colleagues, reposted below.
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Bhandoola_Lab retweeted
Nature Immunology@NatImmunol
8 Jul 2024
Vivier and colleagues integrated scRNA-seq and CITE-seq data to provide a resource of human NK cell heterogeneity in healthy tissues and in the tumor setting. Read it here: rdcu.be/dM61D nature.com/articles/s41590-0…

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And here are the links to the two new papers in Nature Immunology. From us and our collaborators @SimonGrassmann, @SunLab_Official, @BelkaidLab nature.com/articles/s41590-0… From the lab of Bendelac and McDonald: nature.com/articles/s41590-0…
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And here is the thoughtful N&V from Emma Patey & @bjorkstrom_lab nature.com/articles/s41590-0…
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Such a bittersweet surprise to be back to back in Nature Immunology with Albert. To my thinking, our two papers are very complementary.
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The original papers are here, one from our lab, one from the lab of Albert Bendelac. rdcu.be/dKS3i rdcu.be/dKS9d
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Bhandoola_Lab retweeted
ImmuNoah'sArk@immunonoah
15 Jun 2024
Great summary from Emma Patey & @bjorkstrom_lab about the 2 recent papers studying NK cell developmental origins from the late Bendelac's lab & the Bhandoola's lab: nature.com/articles/s41590-0… ILCs with more nuance! Orginal studies: rdcu.be/dKS3i rdcu.be/dKS9d
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Bhandoola_Lab retweeted
Nature Immunology@NatImmunol
14 Jun 2024
Bhandoola and colleagues describe the existence of two developmental pathways that give rise to functionally distinct NK cell subsets. Read it here: rdcu.be/dKPp7 nature.com/articles/s41590-0…

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The CCR media team has a succinct outline of this latest work from our lab: x.com/NCIResearchCtr/status/…
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Bhandoola_Lab retweeted
Immunity@ImmunityCP
26 Apr 2024
Online now: Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut dlvr.it/T63Tgk
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science.org/doi/full/10.1126… Other recent work from our lab. Stay tuned for more.

Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus...

Klf6 is required in thymic epithelial cells for normal thymic development and the establishment of T cell tolerance.

science.org
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And here's the link to the paper itself, below. nature.com/articles/s41586-0…

Bone marrow plasma cells require P2RX4 to sense extracellular ATP

Nature - We demonstrate the role of the ligand-gated purinergic ion channel P2RX4 in maintaining mouse plasma cells in their bone marrow niche.

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Bone marrow plasma cells require P2RX4 to sense extracellular ATP rdcu.be/dyDzS The link is to a web-readable version of our lab's first paper on plasma cells. From a very fun collaboration between our lab at the National Cancer Institute and David Allman's lab at Penn.
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