Thrilled to share our latest study to understand the genomic and epigenetic roles of TDP-43 in regulating local gene expression, long range promoter-enhancer interaction and transposable elements expression via R-loop and 5hmC crosstalk.
cell.com/cell-reports/fullte…
Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental glial biology to stem cells and tumor biology. rdcu.be/d5ADz A 🧵(also come to 🦋!)
Wang, Li and coll. identify in the cortex of Alzheimer's disease mice models and human patients a dysregulated circRNA signature associated with the pathological mechanisms leading to neurodegenerative progression.
Read the full paper here:
genomemedicine.biomedcentral…@BingYaoLab
Happy to share our recent work on circRNA dysregulation associated with AD progression. Hard work by postdoc Feng Wang and Yangping Li. Great collaboration with @YueFeng04338925.
link.springer.com/article/10…
Happy to share our recent work on circRNA dysregulation associated with AD progression. Hard work by postdoc Feng Wang and Yangping Li. Great collaboration with @YueFeng04338925.
link.springer.com/article/10…
Congratulations to Rachel Seong on her Emory undergraduate Honors thesis defense, highest honor! Thanks to thesis committee members @LeilaRieder@pengjinATL
Thrilled to share our latest study to understand the genomic and epigenetic roles of TDP-43 in regulating local gene expression, long range promoter-enhancer interaction and transposable elements expression via R-loop and 5hmC crosstalk.
cell.com/cell-reports/fullte…
Our results not only provide a common mechanism underlying genome-wide DNA modification dysregulation across several neurodegenerative disorders involved in TDP-43 proteinopathies, but also point to a general genomic roles RNA-binding proteins in brain functions and diseases.
Exciting updates for users of BrainRNAseq.org ! The site may look the same at first glance, but it has been completely rebuilt from the ground up with important features!
Will be Assoc Prof this Sept, thanks for all the support from mentors, colleagues, friends and family. Special thanks to all past and present lab members.
Happy to share @emorygmb student Kat Westover has received her NRSA F31 award from @NINDSfunding. Huge thanks to @acorbe2 for co-sponsoring her study on R-loops dysregulation in in Ataxia Telangiectasia.