Joined November 2023
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12 Nov 2023
Welcome to BioIron Social!
The International BioIron Society focuses on the biology and chemistry of iron metabolism, pathogenesis of iron disorders, and development of new diagnostics and therapeutics for patients with iron disorders. Find us at bioiron.org
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Jun 13
📢Save the Date!
We are excited to announce the second session of the BIOIRON Webinar Series 2026 organized by the Junior Board.
Our featured speaker, Dr. Tslil Ast, PI at the Weizmann Institute of Science (Israel), will present a seminar on:
🧠“Iron in Mitochondria”
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Jun 13
Dr. Ast’s research focuses on iron-sulfur (Fe-S) cluster biology, mitochondrial function, and the role of iron metabolism in human disease.
This webinar offers an excellent opportunity to engage with leading researchers in the fields of iron biology and mitochondrial metabolism
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Jun 13
🗓 25 June 2026
⏰ 11:00 AM (EST)
💻 Online via Zoom
🔗Free registration:
us02web.zoom.us/meeting/regi…
After registration, participants will receive a confirmation email with the meeting link and access details.
We look forward to welcoming you online!
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Spotlight Paper!
📢 “Characterization of ferroportin disease and SLC40A1-related hemochromatosis – Results from the EASL non-HFE registry.”
Troppmair et al., 2025. Journal of Hepatology
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🚀 Takeaways
Patients with the same SLC40A1 variant show very different iron overload patterns and liver risk, highlighting the need for individualized assessment.
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SLC40A1‑related hemochromatosis is linked to higher transferrin saturation and greater fibrosis risk than classic ferroportin disease, emphasizing tailored monitoring and management.
Read the full paper:
journal-of-hepatology.eu/art…
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Featuring BioIron Labs Around the World Nai Lab At the BioIron Society, we proudly highlight leading research groups advancing iron biology and medicine worldwide.
🌍 This week, we feature Dr. Antonella Nai's Laboratory!
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Their work aims to identify new therapeutic strategies for iron-related disorders, integrating molecular biology, genetics, and translational approaches.
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💬 How can deeper insights into iron regulatory networks like the hepcidin–BMP-SMAD axis accelerate the development of new therapies for both iron overload and iron-deficiency disorders?
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Spotlight Paper!
📢 “A TMPRSS6-inhibiting mAb improves disease in a β-thalassemia mouse model and reduces iron in healthy humans.”
Heinrich E. Lob et al., 2025. JCI Insight
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🔑 Key highlights
🐭 In a β-thalassemia mouse model: reduced liver iron improved red cell parameters
🧪 In healthy humans (Phase I): increased hepcidin and reduced serum iron with acceptable safety
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🚀 Takeaway
TMPRSS6 inhibition shows strong translational potential as a dual-action strategy to control iron overload while improving erythropoiesis.
Read the full paper: 10.1172/jci.insight.191813
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🔑 Key highlights
🐭 In a β-thalassemia mouse model: reduced liver iron improved red cell parameters
🧪 In healthy humans (Phase I): increased hepcidin and reduced serum iron with acceptable safety
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🚀 Takeaway
TMPRSS6 inhibition shows strong translational potential as a dual-action strategy to control iron overload while improving erythropoiesis.
Read the full paper: 10.1172/jci.insight.191813
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