inveterate BioOptimist | PhD | humanist | BAE.eth | love/live w/ @lwsnbaker
Joined November 2015
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12 Mar 2025
What if we replaced "How do we keep AI out of the classroom?" with "How do we teach AI as a tool rather than a crutch?"
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12 Mar 2025
Each year without proper AI instruction is another generation paying the price through diminished cognitive development.
But Educators face a challenge: how do you teach something you haven't been trained in yourself?
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12 Mar 2025
Read "The Moral Imperative to Teach AI" to see how educators will determine whether GenAI becomes pernicious or a panacea: biooptimist.substack.com/p/t…
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22 Jan 2025
Check out the full post exploring the future of biological research, automation, and the hidden forces shaping our experiments here: biooptimist.substack.com/p/n…
22 Jan 2025
Automating cell culture isn't about making science easier - it's about making it better.
By acknowledging rather than denying natural selection in our labs, we're opening new frontiers in biological research.
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22 Jan 2025
Automating cell culture isn't about making science easier - it's about making it better.
By acknowledging rather than denying natural selection in our labs, we're opening new frontiers in biological research.
22 Jan 2025
As labs modernize and bring in automation, there's an opportunity to do better. We need to rethink cell culture from the ground up, just like the alarm clock reinvented wake-up calls.
Enter: self-driving cell culture systems.
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22 Jan 2025
As labs modernize and bring in automation, there's an opportunity to do better. We need to rethink cell culture from the ground up, just like the alarm clock reinvented wake-up calls.
Enter: self-driving cell culture systems.
22 Jan 2025
This problem has been known for over 50 years, yet most labs still avoid regular cell verification.
Some argue time and cost, but fundamentally it's a workflow problem.
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22 Jan 2025
This problem has been known for over 50 years, yet most labs still avoid regular cell verification.
Some argue time and cost, but fundamentally it's a workflow problem.
22 Jan 2025
In part because of the mechanisms of selection at play, 5-46% of cell lines in research labs are misidentified.
Even samples from originating labs are wrong 18% of the time. We're often not working with what we think we are.
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22 Jan 2025
In part because of the mechanisms of selection at play, 5-46% of cell lines in research labs are misidentified.
Even samples from originating labs are wrong 18% of the time. We're often not working with what we think we are.
22 Jan 2025
Biologists face a paradox: they want to minimize variability to more easily analyze their results, BUT they are studying systems that evolved to have high variability as an evolutionary survival strategy.
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22 Jan 2025
Biologists face a paradox: they want to minimize variability to more easily analyze their results, BUT they are studying systems that evolved to have high variability as an evolutionary survival strategy.
22 Jan 2025
So point 1 - natural selection and survival of the fittest takes place EVERYWHERE, including experimental labs.
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22 Jan 2025
So point 1 - natural selection and survival of the fittest takes place EVERYWHERE, including experimental labs.
22 Jan 2025
Take HeLa cells as an example. Did you know these immortal cells are so good at surviving that they literally invade other cell lines?
One study found that 67% of misidentified cells had been overtaken by HeLa cells.
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22 Jan 2025
Take HeLa cells as an example. Did you know these immortal cells are so good at surviving that they literally invade other cell lines?
One study found that 67% of misidentified cells had been overtaken by HeLa cells.
22 Jan 2025
High school bio told you about the peppered moth and it's changes due to pollution during the industrial revolution.
Lab specimens are doing the same thing under our noses, but the consequences for research are far more complicated.
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22 Jan 2025
High school bio told you about the peppered moth and it's changes due to pollution during the industrial revolution.
Lab specimens are doing the same thing under our noses, but the consequences for research are far more complicated.
22 Jan 2025
Natural selection doesn't just happen in nature - it's actively shaping laboratory experiments (and sometimes undermines them)
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22 Jan 2025
Natural selection doesn't just happen in nature - it's actively shaping laboratory experiments (and sometimes undermines them)
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14 Jan 2025
The scientific method you were taught is outdated - it’s time to move beyond the enlightenment and into the modern era with automation and AI
biooptimist.substack.com/p/b…
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14 Jan 2025
Prediction 2: The structure of hypotheses will change, rejecting the model of a single null and alternate hypotheses pair searching for causality in favor of
1) exploring the number of alternate hypotheses explored
2) increased focus and sensitivity to modulatory effects
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14 Jan 2025
Prediction 3: New statistical approaches will
1) attempt to quantify and measure the probability of validity
2) assess the resiliency of the proposed model
3) assess the resiliency of the biological system
4) result in numerical-based assessments of modulatory impact
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