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BioSpherix, LLC @BioSpherix

BioSpherix, LLC is dedicated to the manufacturing of laboratory equipment for controlling and maintaining in-vitro (cell) and in-vivo (animal) environments.

Joined February 2011
  • Tweets 445
  • Following 229
  • Followers 260
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BioSpherix, LLC@BioSpherix
13 May 2022
Citing our products is easier than ever: every item on our website has an RRID. Cite easily, promote reproducibility: biospherix.com/oxycycler-c42…
Join us at ASME's free webinar to discuss exciting advancements in biomedical innovation! Register now: asme.zoom.us/webinar/registe…
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Have your cell cultures been naughty this year, or nice? Happy Holidays, from the BioSpherix family.
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BioSpherix, LLC retweeted
BioSpherix Medical@BioSpherixMD
29 Nov 2022
How do we measure parameters for biofabricated tissues? What critical aspects of tissue engineered products remain unmonitored? Join us Dec 1st at NIST's virtual workshop to discuss measurement needs, future directions, and more. nist.gov/news-events/events/…

Workshop on Measurement Needs for Biofabrication of Tissue Engineered Medical Products

Quick Links

nist.gov
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Osteogenesis and HIF Signaling in the Clinic: An in-depth review of recent progress in HIF-regulated bone regeneration provides evidence for novel tissue repair strategies. Read more: pubmed.ncbi.nlm.nih.gov/3591… #Cytocentric #Cellculture #tissueeng #hypoxia #physioxia

HIF signaling: A new propellant in bone regeneration - PubMed

Bone tissue destruction leads to severe pain, physical flaws, and loss of motility. Bone repair using biocompatible and osteo-inductive scaffolds is regarded as a viable and potential therapeutic...

pubmed.ncbi.nlm.nih.gov
BioSpherix, LLC retweeted
Phase Holographic Imaging@PhaseHolo
15 Nov 2022
We are so thrilled to share this news! phiab.com/pressrelease/phi-s… #regenerativemedicine #biomanufacturing #celltherapies #holomonitor @BioSpherix @QIAGEN @WFIRMnews @SASsoftware
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Identifying EV Uptake Signals in Pancreatic Cancer: Nigri et al. mimic pathophysiologic conditions to identify a potential target for therapeutic intervention into aggressive PDAC. Read more (open access): pubmed.ncbi.nlm.nih.gov/3591… #Cytocentric #Cellculture #hypoxia #physioxia

CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote...

In pancreatic ductal adenocarcinoma (PDAC), signaling from stromal cells is implicated in metastatic progression. Tumor-stroma cross-talk is often mediated through extracellular vesicles (EVs). We...

pubmed.ncbi.nlm.nih.gov
Intestinal Wound Healing and HIF: Steiner et al. review the double-edged sword HIF present over the course of the metabolic response to chronic intestinal inflammation. Read more: pubmed.ncbi.nlm.nih.gov/3591… #Cytocentric #Cellculture #HIF #hypoxia #physioxia #metabolism

Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis...

The healthy mammalian intestine is lined by a single layer of epithelial cells. These cells provide a selectively permeable barrier to luminal contents and normally do so in an efficient and effect...

pubmed.ncbi.nlm.nih.gov
Neuroinflammation Regulation Therapies Tested Using Hypoxia: Wang et al. recreate pathophysiological conditions to study neuroprotection after cardiac arrest-induced brain injury. Read more: pubmed.ncbi.nlm.nih.gov/3592… #Cytocentric #Cellculture #NSC #hypoxia #physioxia

Neuroprotection of NSC Therapy is Superior to Glibenclamide in Cardiac Arrest-Induced Brain Injury...

Cardiac arrest (CA) is common and devastating, and neuroprotective therapies for brain injury after CA remain limited. Neuroinflammation has been a target for two promising but underdeveloped post-CA...

pubmed.ncbi.nlm.nih.gov
Goldilocks, Radiation, and Cataracts in Space: Richard B. Richardson details the role of oxygen in cataract development in US astronauts. Read more (open access): pubmed.ncbi.nlm.nih.gov/3591… #Cytocentric #Cellculture #cataract #oxygen #hypoxia #physioxia

The role of oxygen and the Goldilocks range in the development of cataracts induced by space...

This article explores the role that oxygen levels in US spacecraft from 1961 to 1998 have on the development of cataracts induced by space radiation in astronauts and whether oxygen levels are well...

pubmed.ncbi.nlm.nih.gov
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B Cell Function, Development, and Metabolism are Regulated by HIF: A comprehensive review by Zhang et al. of immunoregulation by hypoxia and hypoxia-inducible factors. Read more (open access): frontiersin.org/articles/10.… #Cytocentric #Cellculture #Bcell #HIF #hypoxia #physioxia
Photosynthetic Gel for Wound Healing: Zhu et al. mimic peripheral artery disease in vitro to develop a novel topical gel to enhance localized hyperoxygenation. Read more (open access): nature.com/articles/s41598-0… #Cytocentric #Cellculture #hypoxia #physioxia
Hypoxia Improves MSC Therapeutic Potential: Silvestro et al. study congenital pulmonary airway malformations in infants and detail the role of hypoxia in therapeutic MSC applications. Read more (open access): pubmed.ncbi.nlm.nih.gov/3577… #Cytocentric #Cellculture #MSC #hypoxia

The Role of Hypoxia in Improving the Therapeutic Potential of Mesenchymal Stromal Cells. A Compar...

Mesenchymal stromal cells (MSCs) play an important role in the field of regenerative medicine thanks to their immunomodulatory properties and their ability to secrete paracrine factors. The use of...

pubmed.ncbi.nlm.nih.gov
Mimicking the TME in Immunotherapy Studies: Ma et al. discuss drug resistance and epigenetic vulnerability in triple negative breast cancer. Read more (open access): pubmed.ncbi.nlm.nih.gov/3584… #Cytocentric #Cellculture #TME #Immunotherapy #hypoxia #physioxia

Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer...

The hypoxic tumor microenvironment has been implicated in immune escape, but the underlying mechanism remains elusive. Using an in vitro culture system modeling human T cell dysfunction and exhaust...

pubmed.ncbi.nlm.nih.gov
Physioxia Diminishes Cellular Iron Dependency: New biosensors uncover altered cell metabolism in this study by Sevimli et al. Read more (open access): sciencedirect.com/science/ar… #Cytocentric #Cellculture #Biosensing #Metabolism #hypoxia #physioxia
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Simulating Pathological Hypoxia to Study Neurodegeneration: Thinard et al. discuss a novel approach to therapy at the blood brain barrier. Read more (open access): mdpi.com/1999-4923/14/7/1418 #Cytocentric #Cellculture #BBB #hypoxia #physioxia

“Endothelial Antibody Factory” at the Blood Brain Barrier: Novel Approach to Therapy of Neurodege...

The failures of anti-β-amyloid immunotherapies suggested that the very low fraction of injected antibodies reaching the brain parenchyma due to the filtering effect of the BBB may be a reason for the...

mdpi.com
Physioxia Influences Gene Methylation: Dogan et al. use physiological oxygen to examine epigenetic modification in pluripotent stem cells. Read more (open access): ncbi.nlm.nih.gov/pmc/article… #Cytocentric #Cellculture #hypoxia #physioxia
Altering O2 in Solid Tumor Studies: Herrera-Campos et al. review the role of hyperoxia and the immune system in novel treatments for solid tumors. Read more (open access): mdpi.com/2072-6694/14/11/274… #Cytocentric #Cellculture #Cancer #hypoxia #physioxia
Enhanced Self-Renewal of HSC Under Physioxia: Physioxia induces downregulation of Tet2 in Hematopoietic Stem Cells, report Aljoufi et al. Read more (open access): ashpublications.org/blood/ar… #Cytocentric #Cellculture #HSC #hypoxia #physioxia

Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced...

Aljoufi et al examined the mechanistic basis for the negative impact of ambient air on hematopoietic stem cell (HSC) self-renewal when compared to physioxi

ashpublications.org
Oxygen Controls the Lymphovascular-Immune Ensemble: Schito et al. review the role of hypoxia in the lymphatic system's response to cancer. Read more: cell.com/trends/cancer/fullt…? #Cytocentric #Cellculture #hypoxia #physioxia #Lymphatic
Improving Tox Assay Predictability with Physioxia: Human renal proximal tubular epithelial cells exhibit in vivo-like properties in co-culture under physiological oxygen, Piossek et al. report. Read more: pubmed.ncbi.nlm.nih.gov/3553… #Cytocentric #Cellculture #hypoxia #physioxia #Tox

Physiological oxygen and co-culture with human fibroblasts facilitate in vivo-like properties in...

Reliable prediction of compound mediated nephrotoxicity in humans is still unsatisfactory irrespective of the recent advancements in in silico, in vitro and in vivo models. Therefore, current in...

pubmed.ncbi.nlm.nih.gov
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