Translucence Biosystems is developing technology to enable the next-generation histology revolution.
Joined August 2019
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June is Alzheimer’s and Brain Awareness Month, a time to recognize the impact of Alzheimer’s disease and the importance of continued progress in brain research.
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At Translucence, we are proud to support researchers by developing tissue clearing, light sheet imaging, and AI-powered 3D quantification workflows for Alzheimer's Disease research.
#alzheimersdisease #ADresearch #ENDALZ #AAIC
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As researchers work to better characterize pathology, neuroinflammation, and therapeutic response, whole-brain approaches can provide a more comprehensive view of these processes across the intact brain.
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Alzheimer’s disease is characterized by complex pathology, making spatial context critical for understanding disease biology.
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This month, we recognize the scientists, clinicians, patients, families, and advocates working to advance Alzheimer’s research and deepen our understanding of the brain.
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This video shows β-tubulin labeling across a cleared mouse embryo, highlighting cellular and cytoskeletal organization throughout the intact specimen.
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Whole-sample tissue clearing combined with 3D light-sheet imaging makes it possible to examine these structures within their native spatial context rather than through isolated tissue sections.
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In developmental specimens like this, these workflows provide a more comprehensive view of how tissue organization and neural architecture emerge across the embryo.
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cFos has been used for decades to map neuronal activity, however its expression is not a direct readout of neuronal activity, as cFos expression can be induced by broader signaling pathways, including cAMP-dependent pathways, neurotrophins, and other paracrine factors.
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The Translucence Neuronal Activity Tissue Clearing Kit brings tissue clearing to your lab and enables the measurement of both cFos and Npas4 across the intact mouse brain with validated antibodies.
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Interested in learning more? Visit our website for more information: translucencebio.com/neuronal…
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We are excited to attend the ASGCT 2026 Annual Meeting in #Boston this week, from May 11th to 15th. @ASGCTherapy brings together the global cell and gene therapy community across scientific, translational, and regulatory areas to help advance these critical therapeutic areas.
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If you’re attending and interested in whole-organ tissue clearing and cellular-resolution 3D imaging, Translucence Biosystems Co-Founder and CEO Damian Wheeler will be there and would be glad to connect.
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If you’re working on cell or gene therapy programs and are interested in discussing how intact-tissue workflows could support your research, feel free to connect with Damian on LinkedIn or reach out to info@translucence.bio.
#ASGCT2026 #genetherapy #celltherapy
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Happy #FluorescenceFriday! This visualization shows a cleared whole-mouse spinal cord with left and right motor cortex neurons labeled in different fluorescent colors and traced continuously down the intact spinal cord in 3D.
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By preserving the intact architecture of the tissue, this approach enables visualization of long-range axonal projections and spatial organization that are difficult to reconstruct from traditional sectioned samples.
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Following viral delivery of green and red fluorescent proteins into opposite sides of the motor cortex, tissue clearing and light sheet imaging reveal the descending motor pathways in cellular-resolution.
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