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BioWorld Science @BioWorldScience

Essential discovery and preclinical research news to support crucial drug R&D decisions at the earliest stages.

Joined May 2022
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#EHA2026: With new lenses, a changing view on pediatric cancers (free w/ registration) #preclinical #research #science #news bioworld.com/articles/731957…

EHA 2026: With new lenses, a changing view on pediatric cancers

In the most simplistic view, adult cancers occur because “immature cells are exposed to mutagens, accumulate mutations, and across life ultimately transform into cancer cells,” Franck Bourdeaut told...

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Microbiota modulates the antidepressant effects of GLP-1 analogues (free w/ registration) #preclinical #research #science #news bioworld.com/articles/731833…

Microbiota modulates the antidepressant effects of GLP-1 analogues

Liraglutide, a glucagon-like peptide 1 (GLP-1) receptor agonist used in diabetes and obesity, could alleviate depression through a pathway that does not depend on the GLP-1 receptor but instead on...

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.@Columbia researchers use base editing to modify human embryo genome (free w/ registration) #preclinical #research #science #news bioworld.com/articles/731851…

Columbia researchers use base editing to modify human embryo genome

Scientists at Columbia University have used base editing to make precise changes in the genomes of human embryos, avoiding the damage to chromosomes that occurs following two-stranded DNA cuts with...

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Pre-disease plasma signature may help redefine lung cancer risk (free w/ registration) #biomarkers #diagnostics #cancer #preclinical #research #science #news bioworld.com/articles/731757…

Pre-disease plasma signature may help redefine lung cancer risk

Researchers have identified a 14-protein blood signature that can predict lung cancer risk as much as five years before diagnosis, and the findings could help identify people who could benefit from...

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Skape Bio unlocks GPCR targets with de novo-designed miniproteins (free w/ registration) #preclinical #research #science #news bioworld.com/articles/731737…

Skape Bio unlocks GPCR targets with de novo-designed miniproteins

Modulating G protein-coupled receptors (GPCRs) is one of the major challenges in biomedicine. These are flexible proteins with small, deep binding pockets. The scientific community has explored small...

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TRIM21 marks viruses and bacteria for degradation via autophagy (free w/ registration) #preclinical #research #science #news bioworld.com/articles/731671…
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Innate immunity and microbiome allied against pulmonary fibrosis (free w/ registration) #preclinical #research #science #news bioworld.com/articles/731651…

Innate immunity and microbiome allied against pulmonary fibrosis

The microbiome and a frontline innate antimicrobial sensor, Toll-like receptor 5 (TLR5), play an essential role in the development of idiopathic pulmonary fibrosis (IPF). A scientific collaboration...

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IMU’s $53M series A to advance high-definition immune profiling tech (free w/ registration) #financing #preclinical #research #news bioworld.com/articles/731669…

IMU’s $53M series A to advance high-definition immune profiling tech

IMU Biosciences Ltd. has closed its series A at £40 million (US$53.9 million), adding £28.5 million to the initial close in January 2024, and bringing the total raised since the company’s formation...

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CRISPR-based approach fights pathogenic E. coli (free w/ registration) #preclinical #research #science #news bioworld.com/articles/731575…

CRISPR-based approach fights pathogenic E. coli

Shiga toxin-producing Escherichia coli (STEC) represents a public health threat that can lead to serious problems, such as bloody diarrhea and hemolytic uremic syndrome in children in up to 10%-15%...

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#EASLCongress: Emerging liver disease targets to watch (free w/ registration) #preclinical #research #science #news bioworld.com/articles/731553…

EASL 2026: Emerging liver disease targets to watch

At the recently concluded European Association for the Study of the Liver meeting, presentations underscored how increasingly granular insights into liver pathobiology are driving the rapid identif...

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Pancreatic lesions show #cancer traits but lack stromal support (free w/ registration) #preclinical #research #science #news bioworld.com/articles/731491…

Pancreatic lesions show cancer traits but lack stromal support

The human pancreas often contains lesions that are common in the population and that, although they can become malignant, usually do not. To understand when this occurs and how these pancreatic...

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New evidence links autoimmunity to #longCOVID symptoms (free w/ registration) #preclinical #research #science #news bioworld.com/articles/731473…

New evidence links autoimmunity to long COVID symptoms

Recent findings are reshaping current understanding of the post-infection landscape of SARS-CoV-2. Although previous studies had already suggested that autoimmunity might underlie the persistent...

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#EASLCongress: Rebuilding the liver, from organoids to engineered ducts (free w/ registration) #preclinical #research #science #news bioworld.com/articles/731472…

EASL 2026: Rebuilding the liver, from organoids to engineered ducts

With a historic WHO resolution adopted this week giving countries, for the first time, a mandate to address liver disease affecting 1.5 billion people worldwide, this momentum is strongly reflected...

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Work underway on vaccines, antivirals against rare Bundibugyo Ebola outbreak (free w/ registration) #preclinical #research #science #news bioworld.com/articles/731490…

Work underway on vaccines, antivirals against rare Bundibugyo Ebola outbreak

Less than two weeks after the outbreak was officially declared, animal studies of a newly designed vaccine against the Bundibugyo Ebola virus are now underway in the U.S. and U.K., and the Serum...

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Researchers identify innate immune barrier against #melanoma (free w/ registration) #cancer #preclinical #research #science #news bioworld.com/articles/731270…

Researchers identify innate immune barrier against melanoma

Australian researchers have identified a previously overlooked population of immune cells in the skin that physically restrain melanoma growth by engulfing live melanoma cells, and the discovery...

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Menstrual ‘footprints’ may act as broad personal health markers (free w/one-time registration) bioworld.com/articles/731248… #preclinical #research #science #news #WomensHealth #Biomarkers #MenstrualHealth #MenstrualCycle #ReproductiveScience

Menstrual ‘footprints’ may act as broad personal health markers

WAVES, an algorithm designed to extract menstrual-cycle metrics from physiological signals such as basal body temperature, which oscillates with sex hormones, shows how different parameters change...

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Unmasking the X: EPAC2 shifts the fragile X landscape bioworld.com/articles/731230… #preclinical #research #science #news #FragileXSyndrome #NeurodevelopmentalDisorders

Unmasking the X: EPAC2 shifts the fragile X landscape

Researchers at UCLA have shown that divergent neuronal signaling in fragile X mice converges on EPAC2, a druggable target whose inhibition restores circuit activity and alleviates core behavioral...

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‘Detargeted’ targeted gene therapy improves activity in #Pompe (free w/one-time registration) bioworld.com/articles/731174… #preclinical #research #science #news #genetherapy

‘Detargeted’ targeted gene therapy improves activity in Pompe

A new strategy aims to improve gene therapy for Pompe disease by optimizing both the genetic component that restores the function of a deficient lysosomal enzyme and the vector that delivers it to...

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Bundibugyo is harsh reminder of need for broad vaccine strategies bioworld.com/articles/731311… #biopharma #research #vaccines #preclinical #science

Bundibugyo is harsh reminder of need for broad vaccine strategies

On Sunday, May 17th, 2026, the World Health Organization classified the ongoing Bundibugyo ebolavirus outbreak in the Democratic Republic of Congo (DRC) as a public health emergency of international...

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@BioWorld
May 18
.@WHO declares #Ebola outbreak a public health emergency of international concern bioworld.com/articles/731355… #biopharma #infection

WHO declares Ebola outbreak a public health emergency of international concern

The threat posed by the Ebola outbreak in the Democratic Republic of Congo has intensified, with the confirmation that it is caused by the Bundibugyo species of the virus, for which there are no...

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