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Biophysical Journal @BiophysJ

Biophysical Journal, the premier journal of quantitative biology and leading journal for molecular, cellular, and systems biophysics research.

Joined August 2015
  • Tweets 3,362
  • Following 309
  • Followers 6,359
71 Photos and videos
#OPENACCESS: The impact of glycosylation on the conformational ensembles of β-, δ-, and γ-sarcoglycans. Elham Fazelpour, Gabriel A. Cook, and Martin McCullagh. buff.ly/xCttDS2

The impact of glycosylation on the conformational ensembles of β-, δ-, and γ-sarcoglycans

Glycosylation is a pivotal post-translational modification that influences protein folding, stability, and interactions with direct implications for muscular dystrophy pathogenesis and emerging gene...

cell.com
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Li et al. combine simulations and theory to study how the cytoskeleton regulates membrane protein phase separation during cell adhesion, showing that steric hindrance and membrane protrusive forces can drive membrane condensation together. buff.ly/q0yIg4v

Cytoskeleton-regulated condensation of integral membrane proteins during cell adhesion

Understanding protein condensation and its functional implications has been increasingly recognized as crucial for elucidating physiological functions and pathological disorders as well as for...

cell.com
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Special issue call for papers: Physical Properties of Cells: From Measurement to Medicine, A Tribute to Jochen Guck. buff.ly/Zz8aT80
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#OPENACCESS: Imagine a leaky house where the pumps never stop running. In sickle cells, hyperactive Piezo1 channels increase ion leaks and force cells to burn more fuel (lactate), revealing a hidden metabolic cost of mechanical stress. buff.ly/qQTc66w

Deoxy-Piezo1 hyperactivity elevates pump-leak fluxes and lactate production in sickle cells

Sickle cell disease, a highly debilitating disease affecting millions worldwide, is caused by the homozygous inheritance of the mutant hemoglobin S (HbS), a malaria-stabilized gene conferring...

cell.com
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Hypoxic cancer cells are like race cars driving on flat tires. This study shows that a protein called kindlin-2 helps determine how prostate cancer cell membranes respond under low oxygen, influencing their mechanical resilience and behavior. buff.ly/z8cvM5l

Biophysical membrane responses of hypoxic prostate cancer cells depend on kindlin-2

Lethal prostate cancer migrates through hypoxic regions and contractile muscle using mechanosensitive integrin receptors (specifically, β1 integrin heterodimers) to escape the organ. Kindlin-2 (K2)...

cell.com
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In the New and Notable "The cytoskeleton as an active regulator of membrane-protein condensation: A mesoscale simulation study," Yukang Zhang and Dechang Li highlight the paper "Cytoskeleton-regulated condensation of integral membrane proteins... ." buff.ly/dUDMQ7O

The cytoskeleton as an active regulator of membrane-protein condensation: A mesoscale simulation...

Cell-to-cell adhesion is much more than simply the mechanical gluing together of adjacent surfaces; it is a fundamental process that underpins the structural integrity and functional identity of...

cell.com
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Now predict and evaluate RNA 3D structure more accurately with a new and efficient statistical potential, TriRNASP – benchmarked on extensive test data sets. Link: buff.ly/VQe0fV7

TriRNASP: A knowledge-based potential with three-body effects for accurate RNA structure evaluation

Accurate RNA 3D structure evaluation on candidates is critical for accurate RNA 3D structure predictions. Although some knowledge-based potentials and scoring functions have been developed for RNA 3D...

cell.com
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#OPENACCESS: Dielectrophoresis reveals stimulus-induced remodeling of insulin granule subpopulations. Ashley Archambeau, Teji Korma, Aneesh Deshmukh, Mark A. Hayes, and Kate L. White. buff.ly/U4Uirho

Dielectrophoresis reveals stimulus-induced remodeling of insulin granule subpopulations

The pancreatic β cell contains several functional subpopulations of insulin secretory granules (ISGs). These subpopulations vary in maturity, age, and secretory capacity. Differences in protein and...

cell.com
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#OPENACCESS: Nematic cell alignment shapes how information propagates across a tissue. Winterstrain et al. show that nematic defects can desynchronize signaling, with calcium waves traveling fastest when perpendicular to tissue orientation. buff.ly/FFRs2Bx

Nematic cell alignment directs calcium waves in an epithelial monolayer

Tissues rely on supracellular signals to coordinate their cells over a long range. Two such tissue-scale cues are calcium waves and patterns of cell-cell alignment or nematic order. During wound...

cell.com
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Special Issue: Single-Molecule Approaches to Reveal Structural and Mechanistic Properties of the Genome. buff.ly/7c9NUFP
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#OPENACCESS: Mesoscale simulations of membrane-tethered reactions to parameterize cell-scale models of signaling. Kelvin J. Peterson, Boris M. Slepchenko, and Leslie M. Loew. buff.ly/OOSxztv

Mesoscale simulations of membrane-tethered reactions to parameterize cell-scale models of signaling

Biochemical interactions at membranes are starting points for cell signaling. But reaction kinetics are difficult to measure on two-dimensional (2D) membranes and are usually measured in volumetric...

cell.com
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#OPENACCESS: Osmotic stress triggers fast and reversible PMF collapse in Escherichia coli. Luis Meneses, Farhad Javi, Eric M. Dudebout, Sophia Belser, Jinming Yang, and Navish Wadhwa.
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In the New and Notable "Cellular nematics speeding up calcium propagation," Aashrith Saraswathibhatla highlights the paper "Nematic cell alignment directs calcium waves in an epithelial monolayer." buff.ly/31N5ACs

Cellular nematics speeding up calcium propagation

Supracellular physical and chemical cues dictate collective cell behavior during tissue development, repair, and disease, yet the intertwining nature of these two cues is still unclear. A key...

cell.com
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#OPENACCESS: What happens when a cell freezes from the inside? Like a water pipe bursting during winter, intracellular ice can quietly damage stem cells. Raman spectroscopy lets researchers watch this molecular freeze-drama unfold in real time. buff.ly/Au80rVS

Raman spectroscopic analysis of intracellular ice-induced degradation of mesenchymal stromal cells

Cryopreservation enables the long-term maintenance of cellular characteristics, thereby serving as a foundation for establishing a stable supply chain for cells. However, during the freezing process,...

cell.com
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Special issue call for papers: Foundations of Membrane Biophysics: Dedicated to Wolfgang Helfrich. buff.ly/oVehHa9
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#OPENACCESS: A robust platform that computes NMR relaxation rates (longitudinal and translation) from MD trajectories, benchmarked on a bunch of proteins. Do you need a magnet for measuring relaxation or not, find out yourself! buff.ly/ZPZ1enS

MD2NMR: Linking molecular dynamics with NMR relaxation

Accurate prediction of nuclear magnetic resonance (NMR) relaxation parameters from molecular dynamics (MD) simulation trajectories is essential for quantitatively linking atomistic-scale motions to...

cell.com
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#OPENACCESS: Quantum tunneling in DNA methylation: A computational study using QM/MM and molecular dynamics. Justin Sato, Annabelle Choi, Peace U. Clement, Gisela Alvarez, To Dang, Daniel Erenso, and Horace T. Crogman. buff.ly/D5Sipex

Quantum tunneling in DNA methylation: A computational study using QM/MM and molecular dynamics

DNA methylation is a central epigenetic modification regulating gene expression, chromatin structure, and disease progression. Although commonly treated as a thermally activated enzymatic process,...

cell.com
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In the New and Notable "Hypoxia and the limits of nuclear passage," Iden Kurtaliaj highlights the paper "Hypoxia-driven changes in nuclear morphology as a determinant of cell migration." buff.ly/BwW4bHO

Hypoxia and the limits of nuclear passage

Metastasis is often presented as a molecular story focusing on transcriptional rewiring, epithelial to mesenchymal transition, and immune evasion. Yet, it is also a problem of physics. To dissemina...

cell.com
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New study combining microscopic imaging, AFM, and mass spectrometry reveals hypoxic pancreatic tumors that induce cytoskeletal and nuclear mechanical changes that promote cell invasion, opening new avenues for therapeutic strategies that target mechanics. buff.ly/8kLqfBb
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Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: buff.ly/B65dPzx

The Cytoskeleton—An Important Regulator of Membrane Protein Condensation

In our research, we use both Monte Carlo simulations and mean field theory to investigate how the cytoskeleton affects the condensation of integral membrane proteins during cell adhesion and what...

biophysics.org
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