Studying human immunogenetics to unveil new biological paradigms explaining susceptibility to infection and/or inflammation. #children #immune defects #genetic

Joined July 2017
90 Photos and videos
Latest from us. Led by @he_randolph. What goes rogue in #MISC? 1) Although clinically silent, inflammation persists for months! 2) This is in part due to expansion of T cells that recognize SARS-CoV2 antigens but also cross-react to self antigens. 👇🏼 nam02.safelinks.protection.o…

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This is funny and true. :)
1/ Spotlight on our former trainee Dusan Bogunovic (@BogunovicLab), a postdoctoral fellow in our NY lab from 2010-13 and now Professor of Pediatrics, Vice Chair for Basic Research, and Director of the Center for Genetic Errors of Immunity at @Columbia.
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A must read!
In this Perspective, Casanova @casanova_lab discusses the 30-year history and future implications of emerging science showing that monogenetic lesions, and #autoimmune disorders targeting the same components of host defense, can underlie the same infection hubs.la/Q048F5Zz0
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Latest thoughts. Today in @JExpMed. We are disomic individuals genetically. Transcriptionally we need not be. Here I discuss what we know about this and propose Theory of Personal Evolution. @KidsAtColumbia @ColumbiaMed hubs.la/Q047WZQZ0
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With his greatness. Honoring his greatness. Thank you @Cornell for invitation to Carl Nathan Lectureship. It was wonderful.
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When in Rome… Thank you ImmunITA for hosting me. And thank you for listening to my theory. @KidsAtColumbia @ColumbiaMed
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My favorite meeting is back in NYC. Come join us!!!
1/ The 33rd Annual Henry Kunkel Society Meeting will be held April 16–18, 2026, at @RockefellerUniv in New York. The theme is “Autoantibodies Against Cytokines.”
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Sazeides et al. @BogunovicLab show that human ISG15 deficiency is a monogenic syndrome that poises individuals to a proapoptotic and profibrotic state that can lead to lung and skin damage with scarring and impaired function via chronic inflammation. hubs.la/Q044Ds9W0
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BogunovicLab retweeted
We’re very close, and when we reach 2000 signatures, petition will be sent to @GovKathyHochul ahead of her Executive Budget announcement and revision period throughout January! So share with friends & family! c.org/hwy54dWJDb
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9th NYC IEI Symposium. Tomorrow at Alumni Auditorium on 168th street in NYC. Join us!!! nycpid.wufoo.com/forms/zsz0r…
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BogunovicLab retweeted
4️⃣ Dusan Bogunovic @BogunovicLab reviews how incomplete penetrance in genetic disorders can be influenced by genetic variant quality, genetic and epigenetic modification, environment, and mosaicism. rupress.org/jhi/article/1/4/…
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Abstracts due December 15th. Best wins iPad mini. 9th NYC Inborn Errors of Immunity Symposium. When: Jan 14th, 2026 - 9:00am-3:00pm. Where: Columbia University, Alumni Auditorium, 650 West 168th Street, NY, NY Registration Free: nam02.safelinks.protection.o…
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Come and join us for an amazing symposium. Over 150 already registered. :)
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BogunovicLab retweeted
Abstracts due December 15th. Best wins iPad mini. 9th NYC Inborn Errors of Immunity Symposium. When: Jan 14th, 2026 - 9:00am-3:00pm. Where: Columbia University, Alumni Auditorium, 650 West 168th Street, NY, NY Registration Free: nam02.safelinks.protection.o…
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In just 12 days, we’ll learn whether @GovKathyHochul will adopt the Empire Biomedical Research Institute (EBRI) as a core FY27 initiative. Please SIGN @NYcures PETITION: c.org/MzK9rFrmtL. It is helpful for legislators to know where the support is coming from. #science
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Latest from us for a close to 2025. Led by Kate Hickey, a terrific peds intensivist fellow. Markers of immune dysregulation in pediatric patients with severe bronchiolitis rupress.org/jhi/article/2/2/…
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A Christmas present published today in La Repubblica. Thank you for the coverage. @KidsAtColumbia @ColumbiaMed
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