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Steve Bosinger @BosingerLab

Associate Professor at Emory University. Immunologist; Systems Biologist; Using genomics to study viral infections.

Joined March 2017
  • Tweets 332
  • Following 186
  • Followers 363
35 Photos and videos
Steve Bosinger retweeted
HIPC@hipcProject
20 Nov 2023
Deep analysis of infant #immune responses to #SARSCoV2 (omicron) #proteomics #multiomics From team including our collaborators: @SetteLab @Alba_Grifoni @YupengFeng @BosingerLab @purveshkhatri Bali Pulendran, and others. @CellCellPress cell.com/cell/fulltext/S0092…

Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth

Multi-omics analysis of blood and nasal samples from human infants and their mothers indicates strong and sustained immunity following SARS-CoV-2 infection during the initial months of life.

cell.com
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Join us for a new course offering this October. Registration is limited so be sure to sign up soon.
Emory CFAR@EmoryCFAR
20 Sep 2023
Are you a faculty member, postdoctoral fellow, or graduate student actively engaged in research & looking to master single-cell RNA-Seq data analysis? Attend a new #EmoryCFAR Systems Immunology Core-hosted 8-week course detailed below. Apply here by 9/25: bit.ly/CFARWorkshopFall23
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Our new work with @PaiardiniLab and @elise_viox by @amitupadhyay85 featured by @SciImmunology
Science Immunology@SciImmunology
2 Aug 2023
New primate research by @elise_viox and colleagues from @BosingerLab and @PaiardiniLab corroborates the theory that too little IFN-I exacerbates viral infection, while too much IFN-I leads to harmful immune hyperactivation. scim.ag/3zF
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Steve Bosinger retweeted
Science Immunology@SciImmunology
2 Aug 2023
New primate research by @elise_viox and colleagues from @BosingerLab and @PaiardiniLab corroborates the theory that too little IFN-I exacerbates viral infection, while too much IFN-I leads to harmful immune hyperactivation. scim.ag/3zF
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Steve Bosinger retweeted
Science Immunology@SciImmunology
31 Jul 2023
A new study in animals evaluates how the presence of anti-viral interferon-I (IFN-I) and related signaling affects #SARSCoV2 outcomes. @elise_viox @BosingerLab @PaiardiniLab Learn more: scim.ag/3yf
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1/ Absolutely thrilled to announce the publication of our research on modulation of type I interferon in rhesus macaques! Our work was accomplished through close collaboration with the @PaiardiniLab and has now been featured in @SciImmunology. science.org/doi/10.1126/scii…

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation...

Administration of a mutated IFN-α2 to rhesus macaques limited viral replication and pathogenesis during SARS-CoV-2 infection.

science.org
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9/ We would like to dedicate this study in loving memory of our friend & colleague Timothy Hoang. He made crucial contributions to the fields of HIV cure & SARS-CoV-2 research during his short but impactful career & is remembered for his drive, intelligence, and love of science.
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10/ We would like to thank all of our wonderful collaborators and the funding sources that made this study possible.
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scRNA-Seq showed that IFNmod treatment inhibited accumulation of CD163 MRC1- macrophages & reduced the expression of inflammatory mediators in this subset in BAL. Downregulation of genes related to inflammasome activation, stress response, and cell death was observed in lungs.
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Based on these results, we conclude that although IFN-I is beneficial in controlling SARS-CoV2 replication, excessive uncontrolled inflammation driven by IFN-I-signaling plays an important role in SARS-CoV2 pathogenesis.
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