Merging molecular and systems neuroscience to uncover the ground rules of behaviors. UCSD Professor & HHMI Investigator. Redpin cofounder. World IPA tourist.
Some pics from @cpnoct, @adhikari, and @BrainCaRMA's visit to Seoul. Learned so much at both SNU Symposium on Neural Circuits for Thermoregulation (and feeding behavior ;) #icomes2025. Thanks for inspiring science, great conversations, and fun times!
1/ 🧬 The Cocaine Cure
What if the same drug that hijacks your brain could be used to treat its own addiction?
Scientists are engineering ion channels that only turn on in the presence of cocaine, flipping the reward circuit on its head.
Here’s how it works, and why it matters 👇🏼
🤠Be sure to read to the end if you are also into Fentanyl and Meth
We used protein engineering to develop cocaine-gated ion channels. Our approach simplifies chemogenetic applications for cocaine addiction by having cocaine itself activate inhibitory and/or excitatory channels. Collaboration between @mikelides@BrainCaRMArdcu.be/eCJK4
Two papers that very nicely show effectiveness of PSAM4-GlyR chemogenetics in concert with FDA-approved varenicline or more selective uPSEM792 in pain animal models as well as in IPSC-derived human sensory neurons. eneuro.org/content/early/202…
Eugene Myers @TheGeneMyers, Director Emeritus & research group leader @mpicbg & @csbdresden was honored with the @Caltech Distinguished Alumni Award. He receives recognition for having revolutionized the bioinformatics industry. Congratulations! 🎉mpi-cbg.de/news-outreach/new…
🧵📢
We need to retain talented postdocs in academic science. I'm happy to say that @HHMINEWS has taken a big step forward this week.
$70,000
That's the new starting minimum salary for all postdocs employed in HHMI labs
hhmi.org/sites/default/files… (1/4)
Seven years in the making, this was a massive effort. Only possible through the indefatigable preseeverance of @RubenDVale and @CampagnerDario who have been amazing beyond words. Thank you to everyone involved!
New work from the lab out in Cell today, by En Yang and colleagues:
A brainstem integrator for self-location memory and positional homeostasis in zebrafish
Congrats to amazingly talented @The_En_Yang, and collaborators!
cell.com/cell/fulltext/S0092…
Well funded private biotech Kriya acquired Redpin Therapeutics— this will turbocharge the development of chemogenetic gene therapies.
businesswire.com/news/home/2…
On Wed, 1 - 5 pm, @JLGomezPhD will talk about @BrainCaRMA's newest kick-ass technology & our latest collaboration
733.14 / MM6 Novel chemogenetic receptor activated by cocaine decreases cocaine self-administration in rats via negative feedback modulation of the lateral habenula
And while you are here, also have a look at this manuscript from Rüdiger Klein's lab, showing that transcriptomic CEA cell types are associated with appetitive and aversive behaviours. 👇
biorxiv.org/content/10.1101/…