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Braintime Lab @BraintimeLab

We study how circadian time is processed in the brain. We do biology, some electronics, a bit of mathematics, and just a tint of philosophy.

Joined February 2017
  • Tweets 108
  • Following 138
  • Followers 96
14 Photos and videos
Prof. Masayuki Ikeda's visit to the Braintime Lab.
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The Chronotype Paradox: intrinsic circadian periods are slightly left-skewed, yet human chronotypes are heavily right-skewed. We show stochasticity in sleep pressure accumulation is sufficient to flip the skew. biorxiv.org/content/10.64898…
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Circadian swings in the mood potential protect against falling into mood extremes such as mania and depression, and this helps explain why bipolar disorder and circadian dysfunction subtly interact. Work by Veronica Will (now at UCSD). biorxiv.org/content/10.64898…
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We know use of affective words show circadian fluctuations. Now Vuong and Mariana show circadian structure in embedding space, too: morning peak in local semantic exploration, later peak in global diversity as posts accumulate. arxiv.org/abs/2601.15091
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Non-seasonal infradian (longer-than-24h) rhythm exists in mice in age & sex dependent manner. By Pishan Chang and Hugh Piggins, and our lab’s Vuong. physoc.onlinelibrary.wiley.c…

Differential effects of sex and age on daily and infradian rhythms of mice

Abstract figure legend Summary of age- and sex-dependent differences in behavioural rhythmicity and environmental adaptation in mice. Middle-aged mice of both sexes show weight loss and increased...

physoc.onlinelibrary.wiley.com
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Ben Nguyen explaining his mathematical model of chronotype at the Taiwan Sleep Society Meeting (October 2025).
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Vuong presenting his work on the origins of the heart's circadian rhythm at the Japanese Chronobiology Society 2025 @jsc2025_kyoto meeting in Kyoto. (ヴオンの初めての時間生物学会での発表) #JSC2025
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The earliest circadian clock in the brain is not the SCN. It is the choroid plexus, ticking by ~E12 with intriguing SNIC-like dynamics. Work by Helene Vitet and Vuong Truong @VuongTruong9 biorxiv.org/content/10.1101/…

Choroid Plexus Hosts the Earliest Detectable Circadian Clock in the Brain

Embryonic circadian rhythms support normal development, and maternal chronodisruption is linked to miscarriages and neurodevelopmental risk, yet the identity of the earliest brain circadian oscilla...

biorxiv.org
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New v2 on bioRxiv, with minor revisions with larger n. Conclusions unchanged: the choroid plexus is the earliest brain circadian clock in mouse; onset is SNIC-like; tiny Δ0.5 °C cycles entrain during early development. biorxiv.org/content/10.1101/…

Choroid Plexus Hosts the Earliest Detectable Circadian Clock in the Brain

Embryonic circadian rhythms support normal development, and maternal chronodisruption is linked to miscarriages and neurodevelopmental risks, yet the identity of the earliest brain circadian oscill...

biorxiv.org
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Circadian biologists from Korea, Japan, and Taiwan got together at #KSBNS2025 — Jihwan Myung, Eun Young Kim, Kazuhiro Yagita, and ShihKuo Chen!
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When circadian periods are skewed, the relationship between period variance and coupling strength becomes 2D, creating a geometry of synchronization and macroscopic period. Circadian rhythms across aging can be viewed as movement along this geometry. link.springer.com/article/10…

Modeling the geometry of circadian synchronization and period across aging

Biogerontology - Circadian freerunning periods change across the lifespan, yet most computational models do not reproduce these shifts without assuming additional mechanisms. Although the...

link.springer.com
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Braintime Lab’s Vuong and Sun Lab’s Mariana took a joyful moment to celebrate their upcoming marriage💍 with a one-of-a-kind photo shoot! #BraintimeLab #SunLab #LoveInTheLab #CircadianRhythms #BuryingBeetles #ScienceAndStory
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Our super-postdoc Hélène is back from GRS/GRC after her wonderful talk and poster presentation! We still need to absorb what she learned there—but we are so proud of her. #GRC2025 #HeleneVitet
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The slow ovarian clock (~28 days) is regulated by the brain’s circadian clock (~1 day). Mood stabilizers (e.g. lithium) that affect circadian rhythms may also influence the reproductive cycle. chronobiologyinmedicine.org/…
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The Braintime Lab is looking for a postdoc to join an exploratory project on circadian development and neuroscience. Rodent experiments chance to learn computational modeling. Competitive salary & benefits. Find out more at braintime.tmu.edu.tw
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Our amazing master's student Veronica has officially graduated! Huge congratulations from all of us at Braintime Lab!
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Braintime Lab retweeted
Marcel Binz@marcel_binz
28 Oct 2024
Excited to announce Centaur -- the first foundation model of human cognition. Centaur can predict and simulate human behavior in any experiment expressible in natural language. You can readily download the model from @huggingface and test it yourself: huggingface.co/marcelbinz/Ll…

marcelbinz/Llama-3.1-Centaur-70B-adapter · Hugging Face

We’re on a journey to advance and democratize artificial intelligence through open source and open science.

huggingface.co
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"tumor clocks tick in a different timezone" (!)
Bharath Ananthasubramaniam@TimelyScientist
2 Jun 2025
ML uncovers 24h rhythms in cancer 🕒🧬 Using COFE ☕, we reconstruct #circadian rhythms from human tumor biopsies across 11 #cancer types! Turns out, tumor #clocks tick in a different timezone 🕰️💊 in PLoS Biology 👉 buff.ly/hwx7wNe #Chronotherapy #CircadianMedicine
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Circumventricular organs lining the brain's ventricles have circadian clocks. But why? Reviews and speculations with Rae Silver & Yifan Yao. dx.doi.org/10.1111/ejn.70097

Global Clock Coordination by the Brain Clock in the Suprachiasmatic Nucleus Through Relay and...

The brain clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus receives direct retinal input, thereby providing the entire body with an internal representation of external solar...

onlinelibrary.wiley.com
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Circadian clocks in the body likely 'entrain' themselves rather than hierarchically reset. Given internal cellular feedback, omics (Bharath @TimelyScientist) may accurately predict their phases via connectomics, something single-gene reporters cannot. doi.org/10.1016/j.sleep.2025…
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