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Brownfield Lab @BrownfieldLab

Fans of the lung and the processes that construct and repair them.

Joined August 2022
  • Tweets 12
  • Following 47
  • Followers 16
2 Photos and videos
Please check out our new publication in Nature Communications to learn about when/where AT2s emerge and how their fate plasticity is regulated! Thanks @MayoPCCM @hsphniehsctr @NatureComms @mayoclinicBMB newsnetwork.mayoclinic.org/d… nature.com/articles/s41467-0…

New discovery may unlock regenerative therapies for lung disease - Mayo Clinic News Network

Researchers found the molecular "switch" that forces specialized lung cells to either rebuild tissue or fight infection when lungs are damaged.

newsnetwork.mayoclinic.org
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🫁👩‍🔬Hot off the (pre)press! Alveolar cells flirt with fate ‘til C/EBPα lays down the law. A pulse of Dlk1 suppresses Notch to split AT1/AT2 paths—like molecular speed dating. Injury? CHOP crashes the party. biorxiv.org/content/10.1101/… @MayoClinic @HarvardEnvHlth

A molecular circuit regulates fate plasticity in emerging and adult AT2 cells

Alveolar AT1 and AT2 cells are vital for lung gas exchange and become compromised in several diseases. While key differentiation signals are known, their emergence and fate plasticity are unclear....

biorxiv.org
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My group and I were thrilled to receive our second Notice of Award of an R01 we submitted to Dev2. We thank the study section members,@nih_nhlbi, @HarvardEnvHlth, and @MayoPCCM. We are escatic to pursue the molecular determinants of fate plasticity in the lung!
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My group and I were thrilled to receive our first Notice of Award of an R01 we submitted to LIRR. We thank the study section members, @nih_nhlbi , @HarvardEnvHlth , and @MayoPCCM . We are stoked to pursue the biophysical underpinnings of stem cells in the lung!
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Brownfield Lab retweeted
Stijn De Langhe@Delanghelab
20 Dec 2022
Glad to share our new paper in cell reports. Niche-mediated repair of airways is directed in an occupant-dependent manner: Cell Reports cell.com/cell-reports/fullte…

Niche-mediated repair of airways is directed in an occupant-dependent manner

Lyu et al. show that complete activation of the peribronchial niche involves removal of an inhibitory Shh signal and initiation of an activating Wnt7b signal after airway injury. Communication...

cell.com
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Thanks for bringing attention to our work!
MayoPCCM@MayoPCCM
2 Dec 2022
Read Dr. Brownfield's et al work on alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling. The work by Drs. Brownfield and Krasnow's team will help develop cell-based therapeutics to treat lung disease. @NatureComms go.nature.com/3Bt6jVB
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Brownfield Lab retweeted
Elisabeth Bik@MicrobiomDigest
2 Dec 2022
Oh dear. I am finding new problems in a @CurrentBiology paper by the current Stanford University president, while working at Genentech (but not the corresponding author). cell.com/current-biology/ful… pubpeer.com/publications/963…
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Brownfield Lab retweeted
MayoRegMed@MayoRegMed
1 Dec 2022
.@MayoClinic is one of the first to offer a #RegenMed Ph.D. track to train scientists and physicians to deliver health care of the future. mayocl.in/3VsdUvw
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Brownfield Lab retweeted
MayoRegMed@MayoRegMed
1 Dec 2022
.@MayoClinc #RegenMed is training the regenerative scientists of the future to advance an emerging field focused on rebuilding and restoring health. mayocl.in/3XOELmN

Training scientists to rebuild health - Mayo Clinic News Network

Experts predict that regenerative medicine will transform clinical practice. A conservative estimate is that 20% of future medical and surgical solutions will involve regenerative solutions. Regene...

newsnetwork.mayoclinic.org
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We published @NatureComms! It started @StanfordBiochem, completed @HarvardEnvHlth, and accepted now @MayoPCCM @Mayocliniclabs @MayoRegMed. Thanks @nih_nhlbi @ACSCAN! Next we translate our findings to improve regenerative medicine for the lung! #MayoREGS nature.com/articles/s41467-0…

Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling

Nature Communications - Here the authors show that FGF signaling initiates alveolus development in mouse lung by inducing AT2 fate and a secondary signal for AT1 fate, and continuously maintains...

nature.com
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