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Butler Lab @ UCSB @ButlerLabUCSB
Joined April 2018
  • Tweets 254
  • Following 123
  • Followers 351
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Butler Lab @ UCSB retweeted
ACS Central Science@ACSCentSci
24 Mar 2020
Grab ‘n go: siderophore-binding proteins provide pathogens a quick fix to satisfy their hunger for iron! Read #FirstRxns bit.ly/2UjsDKR by @ADGallo56 & Katherine Franz @FranzLabDuke on the research by the Wencewicz Lab @WashUChem bit.ly/3df202b
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Butler Lab @ UCSB retweeted
Jen Heemstra@jenheemstra
24 Nov 2019
Bragging about huge numbers of hours worked each week misses two important truths: -time at work doesn’t necessarily equal productivity -there is no prize for suffering the most
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Butler Lab @ UCSB retweeted
UC Santa Barbara@ucsantabarbara
9 Oct 2019
.@UCSB_chemistry’s graduate students recently discovered a technique to decipher siderophore's 3D structure. A better understanding this compound potentially means thwarting bacterial growth and treating certain illnesses. Findings appear in @PNASNews. ow.ly/ukWz50wGRxz

Seeing in Stereo

Chemists develop technique to predict siderophore structures from the genes that code for them

news.ucsb.edu
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"Mentoring: Reflections and Suggestions" -- Don't miss this editorial by Harry Gray, pioneer of #bioinorganic chemistry. Alison is a proud member of Gray Nation!
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We're lucky to have Rich in our department!
UC Santa Barbara@ucsantabarbara
30 Sep 2019
Working with just his hand and a very hot flame, #UCSB's in-house glassblower Richard Bock shares his expertise on this niche profession. ow.ly/Iq2p50wtMyE
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Cool! Drosophila melanogaster has a nonribosomal peptide synthetase! pnas.org/node/850115.full
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#UCSB colleagues, sign ups are open for the 2019 Out List! Please consider coming out as member of the LGBTQIA community, or even as a supporter. Visibility matters! @ucsantabarbara @ucsb_rcsgd docs.google.com/forms/d/e/1F…

UCSB Out List 2019 Sign-up

Please enter information that you would like to share on the Out List, which will be published for public viewing at rcsgd.sa.ucsb.edu/out-list on October 11, 2019. All information you enter in this...

docs.google.com
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Butler Lab @ UCSB retweeted
Chemjobber@Chemjobber
19 Sep 2019
When you finish a PhD in chemistry they take you in a special room and tell you that tenure-track professorships aren't real and all professors are just really old postdocs. I am posting this at great physical risk to myself and my family. x.com/ButlerLabUCSB/status/1…

Butler Lab @ UCSB@ButlerLabUCSB
19 Sep 2019
When you finish a PhD in chemistry they take you in a special room and tell you that the periodic table isn't real and all matter is just made of the elements earth, air, fire, and water. I am posting this at great physical risk to myself and my family.
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When you finish a PhD in chemistry they take you in a special room and tell you that the periodic table isn't real and all matter is just made of the elements earth, air, fire, and water. I am posting this at great physical risk to myself and my family.
This tweet is unavailable
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🚨 NEW PAPER ALERT 🚨 Our latest work on amino acid β-hydroxylation in #siderophores is online! pnas.org/content/early/2019/…

Genomic analysis of siderophore β-hydroxylases reveals divergent stereocontrol and expands the...

Genome mining of biosynthetic pathways streamlines discovery of secondary metabolites but can leave ambiguities in the predicted structures, which ...

pnas.org
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more replies
To confirm that we could actually use these trees to predict siderophore structures, Cliff, Jae, and Jean isolated four siderophores and stereochemically characterized the OHAsp residues. Each matched the subtype-based prediction! (10/11)
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To sum up, we can now predict the residue selectivity and stereospecificity of any siderophore β-hydroxylase. Although mechanistic questions remain, structures can now quickly be predicted just by looking at the gene cluster, or better yet, by using the pHMMs provided. (11/11)
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