Bridging the gap between discovery and clinical implementation in #cancer #immunotherapy #immunooncology at @HerlevGentofte Copenhagen. SoMe manager @doniamarco
Joined April 2018
- Tweets 248
- Following 62
- Followers 441
- Likes 504
72 Photos and videos
CCIT-DK: National Center for Cancer Immune Therapy retweeted
📣 Our new paper in @JNCCN: acquired resistance to #immunotherapy (ARI) across 11 tumor types
Reconstructed IPD: 15,199 pts / 41 phase 3 trials
• 73.5% develop ARI by 3y
• Higher CR/PR → less ARI, regardless of tumor type
ARI may be determined by response depth, not histology
Cheers to @DoniaMarco & @CCITdk 🇩🇰
Full paper 👇👇👇
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CCIT-DK: National Center for Cancer Immune Therapy retweeted
📣 New in #EJC: among PD-(L)1 responders, durability tracks response depth, not tumor type
Our nationwide cohort 🇩🇰: 2,127 responders (#melanoma, #RCC, #NSCLC)
• Within CR & within PR, PFS near-identical across tumors
• PR vs CR = dominant factor
Two papers, two faces of the same coin 🪙:
response depth, not tumor type, drives the risk of acquired resistance to IO
Trial-level (@JNCCN) real-world (#EJC), same conclusion
Cheers to @DoniaMarco & @CCITdk
Full paper 👇👇
#LCSM #IO
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🎥 @holmstrom_mo of @CCITdk shares outcomes from a study investigating immune reconstitution in patients with #Myelofibrosis conditioned with a non-myeloablative regimen prior to alloSCT:
➡️ ow.ly/9zC550YXw7F
#MPNsm #BMTsm #HemOnc #ESHMPN2026
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In a recent interview, @holmstrom_mo of @CCITdk discussed the potential of therapeutic cancer vaccines in MPNs, highlighting the challenges of integrating vaccine strategies into treatment. 💉🩸
Click here to watch the full interview:
🎥 👉 ow.ly/cBWP50YXv1I
#ESHMPN2026 #MPNsm #ImmunoOnc #HemOnc
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CCIT-DK: National Center for Cancer Immune Therapy retweeted
20 Oct 2025
🆕 Nationwide real-world (DAMMED 🇩🇰) study comparing Dab/Tram vs Enco/Bini in 751 pts with BRAFm metastatic melanoma.
⚖️ No differences in efficacy
🧩 Consistent across subgroups
(incl. 🧠 mets)
📄 doi.org/10.1093/jnci/djaf263
In @JNCI_Now
@CCITdk @DoniaMarco #Melanoma #Oncology
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@CCITdk is happy to support the candidacy of Professor @ulassen to this important post at ESMO @myESMO
28 May 2025
I am pleased and proud to be a candidate running in the election for the position of Nomination Committee Member for ESMO ESMO - @myESMO @Rigshospitalet @OECI_EEIG @ASCO
esmo.org/about-esmo/how-we-w…
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CCIT-DK: National Center for Cancer Immune Therapy retweeted
24 Apr 2025
Acquired resistance to Cancer Immunotherapy
Free at bit.ly/4jptfZz
➡️ Metastatic cancers can be cured
➡️ Pts who initially respond can develop resistance (up to 65% of responders)
❗One of the top priorities in Oncology
Reviewed in @TrendsMolecMed
@CCITdk @MdCurioni
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CCIT-DK: National Center for Cancer Immune Therapy retweeted
6 Feb 2025
New #JITC article: Arginase-1-specific T cells target and modulate tumor-associated macrophages bit.ly/3PZKkMP @marper2323 @CCITdk
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🎉Cell Therapy Milestone
👍This week, a patient with melanoma received the first non-viral CRISPR-edited TIL infusion product at @CCITdk
Congrats to Cell Therapy team @ozcan_met: from preclinical pubmed.ncbi.nlm.nih.gov/3514… to GMP grade clinicaltrials.gov/study/NCT…
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CCIT-DK: National Center for Cancer Immune Therapy retweeted
5 Nov 2024
📢 Check out this special case report by Monberg, Svane & colleagues @CCITdk @helsinkiuni @Rigshospitalet 🇩🇰🇫🇮.
💉Combined treatment with TILs oncolytic adenovirus (TILT-123) in a patient with metastatic mucosal melanoma.
Available #OpenAccess 👇esmoiotech.org/article/S2590…
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📣 PhD course "Cancer Immunology and Immunotherapy", 4th edition
📃 Course Description and registration 👉bit.ly/40vh1YI
▶WHEN: 07-11/04/2025 (mon-fri)
▶WHERE: Copenhagen Area, Denmark
📩 Full program available soon! Previous edition at bit.ly/3CoqXcB
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📢The Copenhagen Symposium on T Cell Therapy and Cellular Engineering (CATC) 2024
⏰ 24-25 September 2024
📍 Greater Copenhagen, Denmark
More at
catc.dtu.dk/about
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CCIT-DK: National Center for Cancer Immune Therapy retweeted
25 Aug 2024
New publication on #MPNsm from @CCITdk published in @BrJHaem: Peripheral blood lymphocytes (PBL) from patients with CALR mutant #MPNsm display increased levels of surface TGFb and GARP. Probably mediated by enhanced binding of activated platelets to PBL.
doi.org/10.1111/bjh.19711
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📣 Webinar "Adoptive cell immunotherapies for cancer"
SN Oncology Webinar Series on 14 May at 4 pm CEST by @SpringerNature
👉 Free registration at: cassyni.com/events/Y5qVZUYYn…
👩🔬 Speaker: Inge Marie Svane, Director of @CCITdk
👨🎓 Chair: Luca Danelli, Senior Editor @NatureComms
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CCIT-DK: National Center for Cancer Immune Therapy retweeted
16 Apr 2024
💬 Fantastic keynote lecture by Dr. Inge Marie Svane from @CCITdk on TIL therapies at VHIO under the framework of #PragamTIL Annual Meeting.
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CCIT-DK: National Center for Cancer Immune Therapy retweeted
27 Mar 2024
Despite manufacturing costs ~67 000 €, academic TIL therapy for patients with #melanoma is both cost-saving and cost-effective in 🇩🇰 and 🇱🇺
Publicly-funded #celltherapy can be sustainable!
27 Mar 2024
New #JITC article: Cost-effectiveness of treating advanced melanoma with tumor-infiltrating lymphocytes based on an international randomized phase 3 clinical trial bit.ly/3PG0IlP @DoniaMarco @tenHamR @HaanenJohn @ValescaRetel
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CCIT-DK: National Center for Cancer Immune Therapy retweeted
4 Mar 2024
Excited to share our latest article on @jitcancer, where we show that a TGFβ-based immune modulatory vaccine can both directly and indirectly modulate the phenotype of TAMs and CAFs, two high TGFβ-secreting cell subsets in the TME ➡ lnkd.in/dpyf9MPJ @CCITdk
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CCIT-DK: National Center for Cancer Immune Therapy retweeted
14 Mar 2024
New #JITC review: Biomarkers for response to TIL therapy: a comprehensive review bit.ly/43g4Yhe @Vic_albarran @pballestin @DoniaMarco
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📣 The Neoantigen Based Cancer Vaccine Pipeline at Dana Farber Cancer Institute
👨⚕️ by Derin Keskin bit.ly/42KN3yY
🕰 March 8th 2024 at 9.15
📍 Auditorium H2, Herlev Hospital, DK
💻Online at bit.ly/4bK1Lug
‼️Join this seminar, No registration required‼️
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🔬 Murine Models for Cancer Immunotherapy, an analysis of tumor microenvironment (TME) compositions
🐭 Insights into comparative roles of the Lymphoid, Myeloid, and Stromal cell compartments of these models from the TSMI group here in @CCITdk
More at 👉 frontiersin.org/articles/10.…
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