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Cancer Discovery @CD_AACR

Follow Cancer Discovery for high-impact articles and news covering major advances in basic, translational, and clinical cancer research. Published by @AACR.

Joined July 2018
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Cancer Discovery@CD_AACR
Jun 1
The June issue is online. aacrjournals.org/cancerdisco…
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Now online: Longitudinal Plasma Metabolomics Guides Dynamic Risk Assessment and Dietary Modulation for Esophageal Squamous Cell Cancer Chemoimmunotherapy doi.org/10.1158/2159-8290.CD…
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Now online: Neoadjuvant BO-112 and Hypofractionated Radiation Therapy with or without Nivolumab in Soft-Tissue Sarcoma: Preclinical and Phase I Results doi.org/10.1158/2159-8290.CD…
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Look back at #AACR26— David A. Braun, MD, PhD, accepts the 2026 Cancer Discovery Early Career Award at the AACR Journals Reception. Learn more: brnw.ch/21x3fb7 @BraunMDPhD @YaleCancer @YaleMed
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News: PROTEUS May Mean New SOC for Some Prostate Cancers doi.org/10.1158/2159-8290.CD…

PROTEUS May Mean New SOC for Some Prostate Cancers

Abstract:. For people with localized, high-risk prostate cancer, treatment with 6 months of apalutamide and androgen deprivation therapy (ADT) both before and after surgery reduces the risk of...

aacrjournals.org
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News: In Vivo CAR T-Cell Therapy Spurs 100% ORR in Phase I doi.org/10.1158/2159-8290.CD…

In Vivo CAR T-Cell Therapy Spurs 100% ORR in Phase I

Abstract:. In the phase I inMMyCAR study of the in vivo chimeric antigen receptor (CAR) T-cell therapy KLN-1010, all 18 patients with multiple myeloma responded. None of the evaluable patients had...

aacrjournals.org
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Read the Hot Topics article collections, featuring impactful, cutting-edge research published in the AACR Journals: brnw.ch/21x3ely #EACR2026
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I-Mei Siu, PhD, Senior Editor, is attending #EACR2026 and would love to hear about your research. Connect with her to discuss publishing opportunities in the journal.
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Now online: GPNMB Drives Brain Metastasis by Sculpting a Pathologic Endothelial–Immune Interactome doi.org/10.1158/2159-8290.CD…
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Now online: A pan-cancer single-cell analysis of intratumoral copy number diversity and evolution doi.org/10.1158/2159-8290.CD…
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Michele Hartsough, PhD, Senior Editor, is attending the Tumor #Metabolism: New Frontiers in Diet, #Microbiome and Beyond and would love to hear about your research. Connect with her to discuss publishing opportunities in the journal.
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Attending #EACR2026? Visit I-Mei Siu, PhD, Senior Editor, at Table 12 from 13:45 PM – 15:00 PM during the Career Development Session to learn Tips and Tricks to Publish your Work.
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Read the related news piece: Neoantigen Vaccine Spurs Broad Immune Responses doi.org/10.1158/2159-8290.CD…

Neoantigen Vaccine Spurs Broad Immune Responses

A neoantigen vaccine against 209 frameshift peptides elicited strong, broad, and long-lasting immunity in people with Lynch syndrome in a phase Ib/II study, offering a novel approach for preventing...

aacrjournals.org
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Jun 5
At #AACR26, researchers discussed innovative ways to prevent cancer in individuals with Lynch syndrome. Learn more on the #AACRBlog: brnw.ch/21x37nN
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Now online: Gut pathobionts translocate into liver and reshape intrahepatic microbiome to facilitate hepatocellular carcinoma doi.org/10.1158/2159-8290.CD…
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Mechanical Load Is Protective against Cancer Cell Growth in the Heart doi.org/10.1158/2159-8290.CD… A #ResearchWatch summary of a recent study by Giulio Ciucci, Daniela Lorizio, Francesco S. Loffredo, Serena Zacchigna and colleagues.

Mechanical Load Is Protective against Cancer Cell Growth in the Heart

Although the heart is rarely affected by cancer, the mechanisms underlying this resistance remain poorly understood. Because mechanical load has been shown to suppress cardiomyocyte proliferation,...

aacrjournals.org
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Niche Labeling Reveals Pro-Metastatic Immune-Cancer Cell Interactions doi.org/10.1158/2159-8290.CD… A #ResearchWatch summary of a recent study by Zhan Xu, Fengshuo Liu, Xiang H.-F. Zhang and colleagues.

Niche Labeling Reveals Pro-Metastatic Immune-Cancer Cell Interactions

Cell–cell interactions within the tumor microenvironment have implications for metastasis and treatment response. Existing methods to characterize stable cell–cell interactions lack the ability to...

aacrjournals.org
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Androgen Signaling Limits Glioblastoma Growth by Preserving Neuroimmune Functions in the Brain doi.org/10.1158/2159-8290.CD… A #ResearchWatch summary of a recent study by Juyeun Lee, Justin D. Lathia and colleagues.

Androgen Signaling Limits Glioblastoma Growth by Preserving Neuroimmune Functions in the Brain

Many cancers exhibit a male bias in incidence and mortality, and androgens are generally thought to promote tumor progression through immunosuppressive effects. However, Lee and colleagues identified...

aacrjournals.org
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Spatial and Temporal Analysis Characterizes Evolution of Metastatic Lung Cancer doi.org/10.1158/2159-8290.CD… A #ResearchWatch summary of a recent study by Sonya Hessey, Simone Zaccaria, Nicholas McGranahan, Charles Swanton, Mariam Jamal-Hanjani and colleagues.
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Oncogenic and Tumor-Suppressive Events Act on a Progenitor State to Promote or Prevent Malignancy doi.org/10.1158/2159-8290.CD… A #ResearchWatch summary of a recent study by José Reyes, Dana Pe’er, Scott W. Lowe and colleagues.

Oncogenic and Tumor-Suppressive Events Act on a Progenitor State to Promote or Prevent Malignancy

Cancer arises from the convergence of genetic alteration accumulation, escape from regulatory constraints, and a tumor-permissive microenvironment, but how these events coincide to induce the...

aacrjournals.org
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Vascular Gates Limit Immunotherapy Response in Neuroendocrine Cancer doi.org/10.1158/2159-8290.CD… A #ResearchWatch summary of a recent study by Yiyun Wang, Ailing Zhong, Bo Wang, Yan Zhang, Feifei Na, Manli Wang, Yu Liu, Chong Chen and colleagues.

Vascular Gates Limit Immunotherapy Response in Neuroendocrine Cancer

Neuroendocrine cancers (NEC), including small cell lung cancer (SCLC), are rare and aggressive malignancies often not responsive to immunotherapy. The mechanisms underlying this immunosuppressive...

aacrjournals.org
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Age Distinguishes Cancer-Causing Mutations from Positively Selected Bystanders brnw.ch/21x345B A #ResearchWatch summary of a recent study by David Cheek, Kamila Naxerova and colleagues.
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