Excited to share our work on ErbB receptors published today @CellCellPress! Using multicolor, photostable UCNPs, we perform long-term (>15 min) single-particle tracking of EGFR, HER2, and HER3, enabling direct visualization of dimerization in live cells. cell.com/cell/fulltext/S0092…
Researchers in the Peng Lab use custom-built microscopy and nanotechnology to tag and follow the activity of individual proteins in real time.
chemistry.mit.edu/chemistry-…
Congratulations to Samuel Charney, Cole English, Julianna Lian, Alvin Meng, Kiarra Ning, and Abigail Strausbaugh Hjelmstad, who were all selected to receive 2026 @NSF Graduate Research Fellowships!
chemistry.mit.edu/chemistry-…
Excited to share our work on ErbB receptors published today @CellCellPress! Using multicolor, photostable UCNPs, we perform long-term (>15 min) single-particle tracking of EGFR, HER2, and HER3, enabling direct visualization of dimerization in live cells. cell.com/cell/fulltext/S0092…
We also identified stable, ligand-independent heterodimers among all three receptors. These insights offer a comprehensive ErbB interaction network, elucidating diverse dimerization mechanisms and implications for oncogenic signaling.
Congrats to the whole team co-lead by Kaibo, Xiaojie, and João! @broadinstitute@ChemistryMIT in collaboration with Matthew Meyerson, Heidi Greulich, Michael Eck! Thanks to the Johnsson lab for help with SNAP/CLIP tags, and the editor/reviewers for a thoughtful review process.
The 2026 Breakthrough Prize ceremony (“the Oscars for science”) celebrated the achievements of many remarkable scientists and their students and collaborators last weekend. Here’s the video of the show: youtu.be/_CZHeEyZBU0?si=blLQ…. And here’s the segment in which Anne Hathaway and Alex Honnold (who climbed El Capitan free solo) presented the story of baby K.J.’s base editing treatment and introduced Kiran Musunuru, Rebecca Ahrens-Nicklas, Peter Marks, baby K.J. and his wonderful family, and myself: youtu.be/_CZHeEyZBU0?si=blLQ…
⏰ We’re in the final hours of the MIT 24-Hour Challenge, and over halfway to our goal of 100 donors! Donate now to help us continue to create new chemical knowledge and mentor the next generation of the best and brightest students.
mtyc.co/jn4z0f
Happy to share our paper on long-term single-particle tracking in live neurons @nchembio. We showed that the number of active dynein motors can switch stochastically during the long transport, and we resolved the molecular steps of dynein.
nature.com/articles/s41589-0…
Many thanks to mentors and collaborators Steve Chu,@BianxiaoC, Tom Südhof, and coauthors! Also appreciate the constructive feedback from the reviewers.
I'm very grateful for the support from the @BeckmanFnd to develop microscopy techniques to explore biology at the single-molecule level! Honored to join this wonderful community and thanks to my mentors, collaborators, and my lab @broadinstitute@ChemistryMIT!
Congratulations to Dr. Martin Holdren, Kunal Lodaya, Sarah Quinn, Robert-Cristian Raclea, Harrison Toll, Sophia Weng, and Jessica Zhang - these seven incredible mentors have been named recipients of the Department of Chemistry Mentorship Spotlight Award!
chemistry.mit.edu/chemistry-…
Excited to share the first paper from the lab! pubs.acs.org/doi/full/10.102…
Limited by photobleaching in single-molecule imaging? We present multicolor long-term single-particle tracking in live cells for 10 min. The probes are actually stable for more than several hours!
Excited to see our Cover Art @NanoLetters, illustrating that multicolor long-term single-particle tracking can illuminate the lifelong journey of biomolecules. Figure credit to João! @ACS4Authors
Meet @CTSPeng, one of Broad's new core members. Hear from Peng as he describes his lab's work developing novel probes and microscopy techniques that enable long-term imaging in living systems. youtube.com/watch?v=zyYx43tB…