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Camillo Tancredi Strizzi @CTStrizzi
Joined October 2023
  • Tweets 34
  • Following 82
  • Followers 7
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Camillo Tancredi Strizzi@CTStrizzi
10 Sep 2025
đŸ§”1. Aldosterone isn’t just “salt & water.” In modern sodium-rich contexts it drives inflammation, fibrosis, and residual cardiorenal risk. We map physiology → disease → therapies, and argue for reprogramming the signal. Follow the thread ---> doi.org/10.3390/ijms26188829

Aldosterone: From Essential Tubular Regulator to Pathological Driver—Physiology, Disease, and...

Aldosterone is a key regulator of sodium reabsorption, potassium secretion, and acid–base balance along the aldosterone-sensitive distal nephron (ASDN), where it exerts coordinated, segment-specific...

mdpi.com
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Hundreds of AI models for SLE. Zero FDA/EMA clearances. One used at point of care. We asked of each: if it showed up in your clinic tomorrow, what would you do differently? New review in Lupus, w/ @wisit661 and @FrancescoPesce Pesce. journals.sagepub.com/doi/10.


Artificial intelligence in the care of systemic lupus erythematosus: Current capabilities and...

Background The clinical heterogeneity of systemic lupus erythematosus exceeds the resolution of conventional disease activity instruments. Artificial intelligen...

journals.sagepub.com
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Camillo Tancredi Strizzi retweeted
Hans-Joachim Anders@hjanders_hans
14 Sep 2025
Now open access in @NDTsocial CKD of unexplained cause (CKDx): A consensus statement by the Genes &Kidney Working Group of the ERA 🧐Check also our 2 open access editorials on this innovative concept. ▶academic.oup.com/ndt/article

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Where does aldosterone actually do its work? In the aldosterone-sensitive distal nephron (ASDN): DCT2, CNT, and the collecting duct. The control room for Naâș balance and Kâș homeostasis. (Follow the thread đŸ§”) #Nephpearls #Nephrology #Physiology
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3. Connecting Tubule/Collecting Duct α-Intercalated cell 🎯 Aldo → Hâș secretion (H-ATPase/H/K-ATPase) ÎČ-Intercalated cell (base/Cl⁻) 🛑Aldo suppresses Pendrin (Cl/HCO₃ handling) đŸ§ȘAldosterone excess contribute to metabolic alkalosis with hypokalemia.
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Full paper available in open access, in collaboration with @Violadmb & @FrancescoPesce. @IJMS_MDPI doi.org/10.3390/ijms26188829

Aldosterone: From Essential Tubular Regulator to Pathological Driver—Physiology, Disease, and...

Aldosterone is a key regulator of sodium reabsorption, potassium secretion, and acid–base balance along the aldosterone-sensitive distal nephron (ASDN), where it exerts coordinated, segment-specific...

mdpi.com
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đŸ§”1. Aldosterone isn’t just “salt & water.” In modern sodium-rich contexts it drives inflammation, fibrosis, and residual cardiorenal risk. We map physiology → disease → therapies, and argue for reprogramming the signal. Follow the thread ---> doi.org/10.3390/ijms26188829

Aldosterone: From Essential Tubular Regulator to Pathological Driver—Physiology, Disease, and...

Aldosterone is a key regulator of sodium reabsorption, potassium secretion, and acid–base balance along the aldosterone-sensitive distal nephron (ASDN), where it exerts coordinated, segment-specific...

mdpi.com
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7. Future & biomarkers 🔬 Non-genomic pathways (GPER), NLRP3 blockade, TLR/biglycan axis, miRNA, immune re-balancing and others. 👉The goal: pathway-informed, biomarker-guided precision nephrology.
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8. Aldosterone: From Essential Tubular Regulator to Pathological Driver—Physiology, Disease, and Therapeutic Advances. In collaboration with @FrancescoPesce @DAmbrosioViola Open Access in @IJMS_MDPI: doi.org/10.3390/ijms26188829

Aldosterone: From Essential Tubular Regulator to Pathological Driver—Physiology, Disease, and...

Aldosterone is a key regulator of sodium reabsorption, potassium secretion, and acid–base balance along the aldosterone-sensitive distal nephron (ASDN), where it exerts coordinated, segment-specific...

mdpi.com
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The success paradox: better therapies → rarer events → longer, costlier trials. Our proposal: smarter trials, not bigger, use adaptive & pragmatic designs, eGFR slope as surrogate, RWE and continue DHT monitoring. @FrancescoPesce shorturl.at/yEeC3
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Proud to share our new paper: a road map to redesign nephrology clinical trials by pairing modern methodology and computational tools. With @FrancescoPesce. shorturl.at/kDg50
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Camillo Tancredi Strizzi retweeted
Sanjeev Sethi
@SethiRenalPath
8 Feb 2025
Basics of Glomerulonephritis (GN). GBM is key. All patterns can be explained by glomerular basement membrane (GBM) & type of injury. Let’s do one at a time CRESCENTIC GN 1. Results from breach/break of GBM (red arrow) 2. Injury is sudden & severe Eg-ANCA & anti-GBM GN
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Camillo Tancredi Strizzi retweeted
F. Perry Wilson, MD MSCE
@fperrywilson
26 Nov 2024
"Drink more water!" It's the easiest health advice around. Tired? Headache? Trying to be like Tom Brady? Just drink more water. But as a nephrologist, I get asked all the time: How much is the right amount? And the truth is... we don't really know. đŸ§”
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Camillo Tancredi Strizzi retweeted
Tony Breu@tony_breu
16 Nov 2024
1/14 đŸ€” Why do we use iodine as an intravenous contrast agent? The answer requires a review of the composition of the human body and a brief tour of one of my favorites, the Periodic Table of Elements.
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