Functional genomics of breast cancer lab based at the University of Cambridge

Joined February 2020
36 Photos and videos
Pinned Tweet
12 Jun 2023
Carlos was awarded the @FondationARC Léopold Griffuel Award at the European Parliament in Strasbourg today: "I stand on the shoulders of my amazing laboratory group. I share this enormous honour with all of them!" Look forward to his talk at #EACR2023 on 13/6 at 4.30 pm! #bcsm
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CaldasLab retweeted
13 Aug 2025
Are you looking for a statistics/ML postdoc? Come to work with @antonis02 and me in the NEMO study, an international collaboration aiming to detect ovarian cancer earlier through cutting-edge multi-omics, funded by the Alliance for Cancer Early Detection. cam.ac.uk/jobs/research-asso…

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Replying to @OMRueda
@omrueda is a fantastic supervisor! Former member of @caldaslab he has an incredible track record! Apply!
13 Aug 2025
Are you looking for a statistics/ML postdoc? Come to work with @antonis02 and me in the NEMO study, an international collaboration aiming to detect ovarian cancer earlier through cutting-edge multi-omics, funded by the Alliance for Cancer Early Detection. cam.ac.uk/jobs/research-asso…
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CaldasLab retweeted
I will be in the awesome @GustaveRoussy in Paris until October to continue my work in #BreastCancer and #DrugScreens. I am grateful to @CRUKresearch, @Cambridge_Uni, Profs @CarlosC24501217 and @FAndreMD for this opportunity. If you stop by Paris let me know!
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The amazing Caldasians! @CaldasLab is made of stars!!
I will be in the awesome @GustaveRoussy in Paris until October to continue my work in #BreastCancer and #DrugScreens. I am grateful to @CRUKresearch, @Cambridge_Uni, Profs @CarlosC24501217 and @FAndreMD for this opportunity. If you stop by Paris let me know!
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Thank you @LautenbergI! I am very proud and look forward to creating an outstanding lab @HebrewU!
Huge congratulations to our dear colleagues, Prof. Alexander Sigal and Prof. Carlos Caldas, on receiving the prestigious “Or” (אור) grant!
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CaldasLab retweeted
I'll soon be recruiting a postdoc fellow to join us @ MRC LMB to continue developing our programme to understand neuroimmune modulation 🧠🔬🧬🩸🫁 If you're interested in joining us check also @MSCActions, @wellcometrust & mrc-lmb.cam.ac.uk/recruitmen… & DM'me youtu.be/-oEXpyjWBFU?si=R8wq…
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Please stay tuned for this upcoming Postdoc position @ MRC LMB with @immunonoah
I'll soon be recruiting a postdoc fellow to join us @ MRC LMB to continue developing our programme to understand neuroimmune modulation 🧠🔬🧬🩸🫁 If you're interested in joining us check also @MSCActions, @wellcometrust & mrc-lmb.cam.ac.uk/recruitmen… & DM'me youtu.be/-oEXpyjWBFU?si=R8wq…
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CaldasLab retweeted
Most #cancer cells aren’t able to propagate tumours—but a rare few can. Using genetic barcodes, a team @PMResearch_UHN tracked these rare clones—revealing how they evolve, adapt, and resist treatment. A step toward more targeted cancer therapies. 🔗: uhnresearch.ca/news/rare-can…
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CaldasLab retweeted
Opinion: In recent decades, the post of Cambridge chancellor has been seen as purely ceremonial. But there is precedent and justification for a more interventionist role, says Wyn Evans timeshighereducation.com/opi…
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CaldasLab retweeted
“[My case] is a new form of ‘cancellation’ of academics prepared to speak out against managerialism. Managerialism is destroying Britain’s universities, and needs to be opposed.“ share.google/I25b5CGgqSFThm0…
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CaldasLab retweeted
This is the pledge card for the Chancellorship of @Cambridge_Uni Details of policies behind the six pledges are here 21percent.org/?p=2245 Chancellor should be helping to fix internal problems of the University @oxonpolis @poppyeh @AnnaFazack1 @VarsityUK @TheTab @BBCCambs
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Amazing presentation delivered by @masina_riccardo @EACRnews #EACR2025 ! He presented our project using PDTCs as high-throughput drug screens, and it was selected as a proffered paper! @CaldasLab @CarlosC24501217
It was an honor to present my work on #DrugScreens in #BreastCancer at the #EACR2025 Congress in Lisbon. Thank you to everyone who attended - and thank you @caldaslab and @Astrazeneca for all the support!
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CaldasLab retweeted
17 Jun 2025
🚀 Xaira Therapeutics has just dropped a game-changer for AI-driven biology. Today, we unveiled X-Atlas/Orion, the largest publicly available genome-wide Perturb-seq dataset to date—spanning 8.4 million single cells with perturbations across all ~20,000 human protein-coding genes. This release is not just about scale—it’s about enabling a new era of causal, mechanistic foundation models for biology. 📝 Preprint on bioRxiv: biorxiv.org/content/10.1101/… 📂 Dataset on Figshare: doi.org/10.25452/figshare.pl… 🔍 What makes X-Atlas/Orion special: 📈 Unprecedented scale & quality: Each cell profiled with deep (~16k UMIs) transcriptomics and rich metadata 🧪 Quantitative dose-response modeling: Thanks to high-fidelity sgRNA detection and ~4 guides per gene, allowing continuous modeling of genetic effects 🧬 FiCS platform: A fully industrialized single-cell perturbation system enabling rapid, reproducible experiments at massive throughput 🧠 This isn’t just “data.” It’s the biological substrate for building virtual cell models that can generalize, predict, and ultimately power AI-native drug discovery. 💬 My final take: This is a foundational moment for the field. The ability to model how genes affect cell state—quantitatively, causally, and at scale—is what we need to unlock predictive biology. Kudos to the incredible team at Xaira for open-sourcing this resource so the entire community can build on it. #PerturbSeq #SingleCell #Genomics #VirtualCell #FoundationModels #AIForBiology #Xaira #DrugDiscovery #SyntheticBiology #CausalAI More press release: Press release : 🔗 GEN article : genengnews.com/topics/artifi… 🔗 BusinessWire: businesswire.com/news/home/2…
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CaldasLab retweeted
It was an honor to present my work on #DrugScreens in #BreastCancer at the #EACR2025 Congress in Lisbon. Thank you to everyone who attended - and thank you @caldaslab and @Astrazeneca for all the support!
19 Jun 2025
Terrific talk from our superstar clinical fellow Riccardo Masina at #EACR2025! A masterclass into how #ML can be used to extract useful insights for drug discovery from high throughput drug screens in clinically relevant, patient-derived models!
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CaldasLab retweeted
Incredibly humbled & grateful to @ASH_hematology for the honour of the William Dameshek Prize. A recognition that belongs to the awesome scientists I have the privilege of working with every day in @TheDawsonLab @PeterMacRes @GenCancerCentre
18 Jun 2025
ASH is proud to recognize 11 hematologists whose groundbreaking research and leadership have transformed the understanding and care of blood disorders. Congratulations to all! 👏 🔗 ow.ly/EsgX50WbEwx #Hematology #ASHAwards
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19 Jun 2025
Terrific talk from our superstar clinical fellow Riccardo Masina at #EACR2025! A masterclass into how #ML can be used to extract useful insights for drug discovery from high throughput drug screens in clinically relevant, patient-derived models!
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19 Jun 2025
Follow him here for updates on this exciting project: @masina_riccardo!
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CaldasLab retweeted
Thank you @EACR for the travel grant to attend this year’s Congress in Lisbon! If you’re interested in #DrugScreens and #BreastCancer come to my talk on Wednesday at 3:30pm in the #AI symposium!
16 Jun 2025
Huge congratulations to our clinical fellow @masina_riccardo for being one of only 45 #EACR2025 Travel Grant Awardees! Don't miss his talk on using #ML in high throughput drug screens of PDX cells for drug discovery: 3.45pm at the Al Tools in Cancer Research Symposium!
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