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Suleyman Can Akerman @CanAkerman
Joined May 2021
  • Tweets 591
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  • Followers 244
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Autophagosome-targeting single-domain antibody clears tau in patient-derived neurons and improves motor function in tauopathy mice science.org/doi/abs/10.1126/…

Autophagosome-targeting single-domain antibody clears tau in patient-derived neurons and improves...

A brain-penetrant single-domain antibody degrader clears pathological tau and restores motor function in a tauopathy mouse model.

science.org
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NDST3 suppression restores lysosomal acidification and ameliorates amyloid-β and MAPT/tau pathology in Alzheimer’s disease link.springer.com/article/10…

NDST3 suppression restores lysosomal acidification and ameliorates amyloid-β and MAPT/tau pathology...

Translational Neurodegeneration - Impairment of lysosomal acidification has recently been identified as a critical driver of amyloid-β and MAPT/tau pathology in Alzheimer’s disease (AD)....

link.springer.com
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Dysregulation of autophagosome–mitochondria contacts contributes to autophagy dysfunction and neurodegeneration in tauopathy pnas.org/doi/abs/10.1073/pna…

Dysregulation of autophagosome–mitochondria contacts contributes to autophagy dysfunction and...

Mitochondria (Mito) engage in extensive communication with other organelles through membrane contacts. Perturbed mitochondria–organelle interaction...

pnas.org
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Excited to have shared our work on Nucleoporin210 in a tauopathy model at the Northeast Nuclear Envelope 2026 meeting at Yale (sites.google.com/view/nene20…). Thank you to the organizers for putting together such a nice program, and grateful for all the feedback and discussion!
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Mitochondria directly interact with the nuclear pore complex nature.com/articles/s41586-0…

Mitochondria directly interact with the nuclear pore complex

Nature - Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.

nature.com
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Aberrant tau accumulation caused by MAPT mutations induces early pathological changes in axonal transport that are rescued by p38α inhibition nature.com/articles/s41593-0…

Aberrant tau accumulation caused by MAPT mutations induces early pathological changes in axonal...

Nature Neuroscience - Imaging axonal transport in vivo in the mouse cortex reveals that deficits in axonal transport arise at early stages of tau pathology, are caused by enlarged tau envelopes and...

nature.com
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LASER couples damage sensing to ESCRT assembly for lysosome repair nature.com/articles/s41586-0…

LASER couples damage sensing to ESCRT assembly for lysosome repair

Nature - ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.

nature.com
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Universal transcriptomic hallmarks of mammalian ageing and mortality nature.com/articles/s41586-0…

Universal transcriptomic hallmarks of mammalian ageing and mortality

Nature - Integration of gene expression data from multiple tissues across four mammalian species reveals conserved transcriptomic signatures of mammalian ageing and mortality and uncovers the...

nature.com
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In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a mouse model of amyloid pathology link.springer.com/article/10…

In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a...

Molecular Neurodegeneration - Coordinated cell-to-cell communications is crucial for the proper functioning and maintenance of brain activities, and its disruption contributes to neurological...

link.springer.com
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Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice nature.com/articles/s41593-0…

Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates...

Nature Neuroscience - In PS19 mice, microglia-derived glycoprotein nonmetastatic melanoma protein B promotes mitochondrial extracellular vesicle secretion, enabling mitochondrial transfer to...

nature.com
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Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation nature.com/articles/s41467-0…

Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient...

Nature Communications - Accumulation of aggregation-prone proteins is linked to neurodegenerative diseases. Here, the authors show that mitochondrial association hinders cells to efficiently clear...

nature.com
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Tauopathy primes co-filament assembly and dysfunction of TDP-43 biorxiv.org/content/10.64898…
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Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer’s disease pathology nature.com/articles/s43587-0…

Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer’s disease pathology

Nature Aging - Autophagic activity has a protective role in Alzheimer’s disease in mice. Here the authors investigate the role of autophagy-initiating protein ULK1 and report that its...

nature.com
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Local Organization of Biological Membranes Modulates Tau–Lipid Interactions and Fibril formation pubs.acs.org/doi/full/10.102…

Local Organization of Biological Membranes Modulates Tau–Lipid Interactions and Fibril formation

The formation of Tau amyloids is a hallmark of several neurodegenerative diseases, called Tauopathies, including Alzheimer’s disease. In different Tauopathies, Tau amyloid filaments adopt a distinct...

pubs.acs.org
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Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification biorxiv.org/content/10.64898…
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Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation nature.com/articles/s44400-0…

Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosph...

npj Dementia - Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation

nature.com
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Vascular burden attenuates the TDP-43-TMEM106B pathological relationship in neurodegenerative disease with and without Alzheimer disease neuropathological change academic.oup.com/jnen/advanc…

Vascular burden attenuates the TDP-43-TMEM106B pathological relationship in neurodegenerative...

Abstract. TMEM106B, a lysosomal transmembrane protein, is a risk factor for neurodegenerative diseases, including Alzheimer disease (ad) and TDP-43 protein

academic.oup.com
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MALDI mass spectrometry imaging (MSI) reveals molecular and structural heterogeneity of amyloid-β in sporadic Alzheimer’s disease and Down syndrome link.springer.com/article/10…

MALDI mass spectrometry imaging (MSI) reveals molecular and structural heterogeneity of amyloid-β...

Acta Neuropathologica Communications - Alzheimer’s disease (AD) and Down syndrome (DS) are both characterized by early accumulation of amyloid-β (Aβ), but the underlying mechanisms...

link.springer.com
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Neuropathological analysis of an ALS patient carrying a SOD1 missense variant and a C9orf72 repeat expansion link.springer.com/article/10…

Neuropathological analysis of an ALS patient carrying a SOD1 missense variant and a C9orf72 repeat...

Acta Neuropathologica -

link.springer.com
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GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids, brain volume and autophagy nature.com/articles/s41467-0…

GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids,...

Nature Communications - The study identifies novel genetic variants linked to core cerebrospinal fluid Alzheimer’s Disease biomarkers using a genome-wide analysis, showing how endophenotypes...

nature.com
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