Although triple-negative breast cancer (TNBC) is known to be an aggressive subtype, less is understood about the possible role of adjuvant chemotherapy for small T1 tumors < 1 cm. In this retrospective analysis using the real-world database CancerLinQ Discovery®, Dr. Kai Johnson and co-investigators from
@OhioState analyzed recurrence and survival data for a cohort of patients with T1mi/a/b N0 TNBC tumors following curative surgery. Among 159 patients, 48% received adjuvant taxane-cyclophosphamide (TC), 25% received an anthracycline cyclophosphamide followed by a taxane (AC-T), and the rest did not receive adjuvant systemic therapy. After a median follow-up of nearly 5 years, there was a statistically significant benefit in terms of invasive recurrence-free survival and overall survival for patients receiving either TC or AC-T compared with locoregional therapy alone. The authors conclude that there is benefit to adjuvant chemotherapy even in this clinically low-risk population. This study, which used real-world data aggregated from across the CancerLinQ network, provides valuable insights into the optimal management of TNBC, especially for this less commonly encountered subset.
Join us for the poster session at the ASCO Annual Meeting tomorrow, June 2nd, from 9:00 AM to 12:00 PM to learn more. Read the abstract here:
hubs.ly/Q03q4l4D0.