Simplified landmark cardiology trials app 📱 by Justin Sharim MD. Mission: to spread evidence-based medicine worldwide 🌎
Joined March 2022
- Tweets 2,303
- Following 1,192
- Followers 13,882
- Likes 7,796
1,413 Photos and videos
Pinned Tweet
3 Sep 2023
Just a Sunday perusing the Cardiac Trials app📱😎 (sound on 🎶)
apps.apple.com/us/app/cardia…
5
21
95
91,746
Jun 13
GLP1 agonists in HFpEF? GLP1 agonists, initially touted as a therapy for diabetes, have proven successful for weight loss (SURMOUNT Trial), CV event reduction (SELECT Trial), and now - with beneficial effects in HFpEF and obesity. STEP-HFpEF Trial, NEJM 2023 ♥️
4
14
1,159
Cardiac Trials retweeted
11 May 2023
Dual antiplatelet therapy (aspirin clopidogrel) is standard after PCI. But what if anticoagulation is already on board (eg for afib)? This trial compares “double therapy” (anticoag clopidogrel) vs “triple therapy” (anticoag clopidogrel aspirin). WOEST Trial, Lancet 2013 ♥️
3
11
39
7,634
Cardiac Trials retweeted
Jan 10
Nonsteroidal MRA for HFpEF? This trial published earlier this year showed finerenone to improve outcomes — a trial building upon a positive secondary outcome alone years prior in TOPCAT, and adding to our now growing arsenal for HFpEF. FINEARTS-HF Trial, NEJM 2024 ♥️
7
28
2,524
Low dose dopamine to improve renal function in acute decompensated heart failure? Because clinical trials are equally important in showing us what does NOT work. ROSE Trial, JAMA 2013 ♥️
3
7
644
Cardiac Trials retweeted
28 Feb 2024
Complex congenital heart disease - palliative shunts and interventions 🫀
A summary 📚#Cardiology
83
218
15,677
Cardiac Trials retweeted
#2026 Ideal LDL cholesterol targets in patients with known CVD? National guidelines have increasingly targeted lower LDL cholesterol targets over the years. This trial directly supports this practice, with strong evidence in favor of “Lower is Better”. Ez-PAVE Trial, NEJM 2026 ♥️
11
37
2,739
Cardiac Trials retweeted
Jan 19
Afib ablation in patients with comorbid HFrEF? This trial showed reduced mortality and improved EF when compared to medical tx (pharmacological rate or rhythm control), and was in large part behind the 1A rec for ablation in the 2023 Afib guidelines. CASTLE-AF Trial, NEJM 2018 ♥️
2
22
1,991
Rilonacept for recurrent pericarditis? This trial showed this IL-1 inhibitor to reduce symptoms and recurrence after a 2nd episode of recurrent pericarditis despite standard tx. A promising solution for a population historically difficult to manage. RHAPSODY Trial, NEJM 2020 ♥️
6
24
1,539
Cardiac Trials retweeted
Mar 15
First #2026 clinical trial we’ve added to the Cardiac Trials App
Mar 14
#2026 Withdrawing GDMT in patients with improved EF? Lifelong GDMT is standard, long after EF improvement. This trial however showed no outcomes difference with GDMT withdrawal in prior tachycardia mediated cardiomyopathy — once afib was controlled. WITHDRAW-AF Trial, EHJ 2026 ♥️
1
3
12
2,640
Mar 14
#2026 Withdrawing GDMT in patients with improved EF? Lifelong GDMT is standard, long after EF improvement. This trial however showed no outcomes difference with GDMT withdrawal in prior tachycardia mediated cardiomyopathy — once afib was controlled. WITHDRAW-AF Trial, EHJ 2026 ♥️
3
32
108
11,151
Cardiac Trials retweeted
11 Oct 2024
~~ New trials added to Cardiac Trials ~~ Inhibiting transthyretin production to treat cardiac amyloidosis? This trial showed vutrisiran, a novel hepatic transthyretin production inhibitor, to improve outcomes in transthyretin cardiac amyloidosis. HELIOS-B Trial, NEJM 2024 ♥️
1
10
37
4,239
Cardiac Trials retweeted
26 Nov 2023
Myocarditis, Diagnosis and Treatment: a nice summary. 📚 JAMA 2023 ♥️
#Cardiology #CardioTwitter
2
162
573
59,889
Cardiac Trials retweeted
25 Sep 2025
TAVR in asymptomatic patients? This trial showed TAVR to improve outcomes (driven mainly by ⬇️ hospitalizations) in severe aortic stenosis but ABSENCE of symptoms — echoing the smaller RECOVERY trial in “very severe” aortic stenosis in 2020. EARLY TAVR Trial, NEJM 2024 ♥️
1
8
24
2,544
Cardiac Trials retweeted
8 Dec 2023
Approach to genetic testing for cardiomyopathy 🧬👇
JACC HF, 2023 ♥️
#heartfailure #cardiology
3
75
226
16,047
Cardiac Trials retweeted
23 Sep 2023
Recalling mechanisms of Type 2 MI:
Sepsis —> Systemic vasodilation —> inadequate coronary blood flow —> Type 2 MI (supply/demand mismatch)
Tachycardia (due to acute illness) —> decreased duration of diastole —> decreased coronary blood flow —> Type 2 MI (supply/demand mismatch)
1
20
82
10,120
Jan 18
Important to recognize — where does the general rec for routine beta blockade for acute MI originate? This historic (pre-PCI era) RCT, cited in guidelines for decades, saw significant mortality reduction with beta blocker use. BHAT Trial, JAMA 1982 ♥️ #historyofmedicine
Jan 18
Routine beta blockade for acute MI with preserved EF? Standing in stark contrast to historic pre-PCI era beta blocker trials, this landmark trial showed NO outcomes difference — calling into question other “accepted” practices in the modern era. REDUCE-AMI Trial, NEJM 2024 ♥️
1
4
24
3,806
Jan 18
Routine beta blockade for acute MI with preserved EF? Standing in stark contrast to historic pre-PCI era beta blocker trials, this landmark trial showed NO outcomes difference — calling into question other “accepted” practices in the modern era. REDUCE-AMI Trial, NEJM 2024 ♥️
1
5
16
4,872
Jan 18
Important to recognize — where does the general rec for routine beta blockade for acute MI originate? This historic (pre-PCI era) RCT, cited in guidelines for decades, saw significant mortality reduction with beta blocker use. BHAT Trial, JAMA 1982 ♥️
1
8
684