THIS IS THE BEST PAPER OF 2026 SO FAR, A MONUMENTAL BREAKTHROUGH, A REVOLUTION IN THE FIELD OF INFLAMMATORY CONDITIONS: Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine nejm.org/doi/10.1056/NEJMoa2…

Neutralizing interleukin-10 autoantibodies were found in a subgroup of patients with inflammatory bowel disease and in no controls without IBD. Seropositivity was strongly associated with the IBD HLA-DRB1*01:03 risk allele. Full study results: nej.md/4dXZ3od Science behind the Study: Autoantibodies against Cytokines — From Infection to Inflammation nej.md/4e1EZ4s

🦠 Pensez-vous ne jamais avoir eu la COVID ? Le Dr Donald Vinh, spécialiste des maladies infectieuses et microbiologiste au CUSM) et chercheur à L'Institut, fait partie du consortium international « COVID Human Genetic Effort », qui recherche des variants génétiques susceptibles de conférer à un petit nombre de personnes une résistance naturelle à la maladie. Cette initiative vise à identifier les mécanismes biologiques susceptibles de permettre le développement de nouveaux traitements et vaccins. Cet effort de recherche international réunit notamment le @cusm_muhc, @RIMUHC1 et @RockefellerUniv. Dans une interview accordée au @BostonGlobe, le Dr Vinh a fait le point sur les découvertes du groupe à ce jour, notamment concernant les raisons pour lesquelles certaines personnes développent une forme grave de la maladie, tandis que d'autres restent asymptomatiques. Pour en savoir plus: bostonglobe.com/2026/06/03/m… - 🦠 Do you think you’ve never had COVID? Dr. Donald Vinh, an infectious disease specialist and microbiologist at the MUHC and a scientist at The Institute, is part of the international COVID Human Genetic Effort, a consortium investigating genetic variants that may make a small number of people naturally resistant to COVID-19. The initiative aims to identify biological mechanisms that could lead to new treatments and vaccines. This global research effort brings together institutions including the @cusm_muhc, @RIMUHC1 and @RockefellerUniv. In an interview with @BostonGlobe, Dr. Vinh provided an update on the group's findings to date, including insights into why some individuals develop severe disease while others remain asymptomatic. To learn more: bostonglobe.com/2026/06/03/m…

1/ Congratulations to our UK colleagues on this landmark @NEJM study: “Interleukin 10 Autoantibodies and HLA DRB1*01:03 in IBD”nejm.org/doi/full/10.1056/NE… A powerful example of how discoveries from rare monogenic #VEOIBD can illuminate mechanisms relevant to common #IBD.

🌐 Journal of Human Immunity (JHI) is now officially indexed in #PubMed Central and PubMed. This includes all future papers and the complete back catalog dating back to our first issue. Read the full announcement and explore the journal here: 👉 hubs.la/Q04kYFsY0

HERE IS WHY: Autoantibodies against Cytokines — From Infection to Inflammation | New England Journal of Medicine nejm.org/doi/10.1056/NEJMe26…

Really amazing paper by #SimonTravis and group on #IL10autoanibodies #HLA and #IBD in today’s @nejm with comments from @casanova_lab 👍👍 great research from PATIENTS @geteccu @aegastro #ECCO MUST READ for all #IBD aficionados

A valuable contribution that expands our understanding of #CTLA4 biology and highlights the power of human genetics to uncover fundamental mechanisms of immune tolerance. #Immunology #InbornErrorsOfImmunity

Mehmet Cihangir Çatak, Bernice Lo @SidraMedicine, Safa Baris @marmara1883 et al. describe the first case of homozygous #CTLA4 deficiency, which drives severe early-onset #autoimmunity through profound T and B cell dysregulation. hubs.la/Q04kKb-M0 #Diagnostics #Therapeutics

News & Views: A new report in JHI from Catak et al. (hubs.la/Q04kK7NT0) deepens our understanding of human disease associated with loss of #CTLA4 (hubs.la/Q04kKhj40). Helen C. Su discusses the findings: hubs.la/Q04kKcpc0

Beautiful news & views by Helen C. Su: Autosomal recessive human CTLA-4 deficiency with autoimmune infiltration rupress.org/jhi/article/2/5/…

A breakthrough: a recessive form of human CTLA4 deficiency ! A homozygous CTLA-4 variant causes CTLA-4 deficiency with severe immune dysregulation rupress.org/jhi/article/2/5/…

The burden of severe leukocyte adhesion deficiency, type I (LAD-I): A multiple-case study from the caregiver’s perspective rupress.org/jhi/article/2/4/…

@lasidjuniors do not miss this opportunity. Best experience ever!!

The burden of severe leukocyte adhesion deficiency, type I (LAD-I): A multiple-case study from the caregiver’s perspective rupress.org/jhi/article/2/4/…

This multiple-case study from O’Connor @IQVIA_global, Lopez @RocketPharma et al. explores the burdens of illness, caregiving, and treatment for five families with children with severe leukocyte adhesion deficiency, type I (LAD-I). hubs.la/Q04k4DNt0 #InbornErrorsOfImmunity

🔔 We're delighted to share the Abstracts from the 9th Scientific Meeting of the Japanese Society for Immunodeficiency & Autoinflammatory Diseases (JSIAD) (Feb. 14–15, 2026, Sendai). Explore the latest advancements in #IEIs clinical practice & research 👉 hubs.la/Q04k8s250

Our latest work on the role of STING in autoinflammation. STING proton channel activity influences Golgi transit & secretion of cytokines through ArfGAP2. ArfGAP2 promotes STING proton channel activity, cytokine transit, & autoinflammation: Cell cell.com/cell/abstract/S0092…

Attending #FOCIS2026 in San Francisco? Join 📃 Late Breaking Abstract session on Wednesday, June 10, 4pm-6pm! JEM's Executive Editor Natalie Cain (@NatalieCainSci) will be chairing the session 👩‍🏫 🗓️ Be sure to add this session to your schedule! @focisimmunology

New in @CellCellPress! 📣 This study, led by Université Paris Cité and Sorbonne Université collaborators supports a model in which a memory B cell response directed against type-I IFNs is established before severe #viral infection. 🔗 bit.ly/4tRjZmh