@CellGuidance profile picture
Cell Guidance Systems @CellGuidance

A biotechnology company focussed on protein formulation, self-assembling protein hydrogels, exosomes and cytogenetics.

Joined September 2020
  • Tweets 338
  • Following 273
  • Followers 218
280 Photos and videos
Drug-loaded nanoparticles can "hijack" immune cells in the skull's bone marrow, which then follow their natural migration route through microscopic skull-to-meninges channels directly into the brain, no BBB crossing required. Read the full post: lnkd.in/ecJcnSRu
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Received wisdom to settled science: the role of EVs Many theories gain ground before seismic papers change misconceptions. This is a common scientific path that EVs are not alone in. Read more lnkd.in/d9_CcVuH
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Advancing EV Research with Tangential Flow Filtration Tangential Flow Filtration is changing how researchers isolate and process extracellular vesicles. Read more here: lnkd.in/eaiHVHZy #EVResearch #TangentialFlowFiltration #ExtracellularVesicles
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Embryo implantation is a finely choreographed event in which extracellular vesicles have a key role. Learn more in our weekly blog lnkd.in/e6pwfkan
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Why is the brain one of the softest tissues in the human body? Our blog explores how the brain’s extreme softness (≈0.5–1 kPa) makes it behave more like a hydrogel than a fibrous tissue. How does it achieve this level of softness and why? lnkd.in/eM6UgAHH
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Our latest blog post “Cytokines and growth factors: what are International Units?” breaks down why International Units (IU) are sometimes used to express biological activity and why that distinction matters: Read the full article: lnkd.in/e7XGZibP
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Cell Guidance Systems retweeted
Denis Wirtz@deniswirtz
21 Dec 2025
After coarsening, micro-domains made up of aggregated monocytes form on a soft matrix (but not on a stiff matrix). This phase separation is due to a Turing-like combination of local activation of cell-cell adhesion and global inhibition More here: nature.com/articles/s41563-0…
Denis Wirtz@deniswirtz
20 Dec 2025
Human monocytes placed on a soft matrix undergo phase separation into micro domains. On glass/plastic, monocytes do not form such domains. See more details in our recent paper in Nature Materials: nature.com/articles/s41563-0…
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Creating robust chemokine gradients to create cellular niches is simple with PODS sustained release chemokines. Read more in our weekly blog lnkd.in/eJWvY4sq
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Not so rare Rare diseases are so numerous that they are collectively very common. The prospects for people with rare diseases are improving as most diseases are genetic and the tools to identify and correct these errors are improving. Read more lnkd.in/eGYfwjU3
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Exosomes in 2026: hype and potential EVs have increasingly been promoted for their cosmetic benefits. The risk is that poor quality data from cosmetics impacts efforts to develop EVs with clinical benefits Read more in our blog lnkd.in/eYzbJhPv
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The Hunters gene therapy breakthrough announced today highlights the important role of medical charities in funding clinical research for drugs that would not be commercially viable. Read the full blog: lnkd.in/ex2zZUdc
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A novel “shaking sensor” has been developed that enables real-time monitoring of cytokines – paving the way for continuous inflammation tracking and insights into acute and chronic disease management. Read more: lnkd.in/e3mVc9gC #biosensors #cytokine #inflammation
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With the awarding of a Nobel Prize for the discovery of T reg cells, we ask how many immune cells remain to be identified, reshaping how we understand immunity, disease, and therapeutics. Read more here: lnkd.in/e_mJ4t7g #Immunology #SingleCell #Biotech #Discovery
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Researchers using PODS® loaded with BDNF GDNF have shown dramatic improvements in RGC survival and regeneration in vitro and in vivo. ✅ 15× higher survival of transplanted human RGCs ✅ Neuroprotective effects for host retinal cells lnkd.in/eD5j32Ka
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Under pressure: Modeling glaucoma Researchers have engineered an in vitro model of the trabecular meshwork (TM) mimicking chronic disease by combining biomimetic collagen scaffolds with PODS® microcrystals that gradually release TGF-β2 . lnkd.in/eGKB9Ur7 #Glaucoma
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Climate change 🌍 not just rising seas: It may also reshape our biology. Our latest blog explores how heat can damage DNA, alter gene expression, and potentially increase cancer risk. Read here lnkd.in/ep3-aKJx #ClimateChange #CancerRisk #Genetics #PublicHealth
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Can there be any science without standards? Setting Standards: Making Research Scientific Advancing science isn’t just about new discoveries. It’s about how we measure, compare, and agree. lnkd.in/eJb5JgM2
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Cell Guidance Systems retweeted
nature
@Nature
7 Sep 2025
A newly discovered type of immune cell found in fat tissue seems to contribute to the chronic inflammation associated with ageing go.nature.com/3I8VZbA

Newfound immune cell in mice hints at why inflammation spikes with old age

Nature - Pathogen-consuming cells found in fat tissue also play a part in lipid balance.

nature.com
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What Are the Most Effective Ways to Concentrate EVs? EVs often need to be concentrated before purification and downstream analysis. This can be tricky, especially when working with large sample volumes We break down all the options lnkd.in/e5pY-7mA #EVs #exosomes
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We have some exciting news for researchers working with mouse EVs! We've expanded our exosome product portfolio with mouse-validated solutions, bringing the same reliability you trust from CellGS to mouse research. Read more at lnkd.in/eTBZXEPp
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